Disease Information

General Information of the Disease (ID: DIS00097)

Name	Kidney cancer
ICD	ICD-11: 2C90
Resistance Map

Type(s) of Resistant Mechanism of This Disease

ADTT: Aberration of the Drug's Therapeutic Target

DISM: Drug Inactivation by Structure Modification

EADR: Epigenetic Alteration of DNA, RNA or Protein

IDUE: Irregularity in Drug Uptake and Drug Efflux

RTDM: Regulation by the Disease Microenvironment

UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Drug

Approved Drug(s)

19 drug(s) in total

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Sunitinib

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Unusual Activation of Pro-survival Pathway (UAPP)			Click to Show/Hide
Key Molecule: Platelet-derived growth factor receptor beta (PDGFRB)				[1]
Resistant Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Resistant Drug	Sunitinib			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Differential expression of the molecule in resistant disease
Classification of Disease	Kidney cancer [ICD-11: 2C90]
The Specified Disease	Renal cell carcinoma
The Studied Tissue	Blood
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 8.34E-01 Fold-change: 2.84E-02 Z-score: 2.17E-01
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Caki-2 cells	Kidney	Homo sapiens (Human)	CVCL_0235
Experiment for Molecule Alteration	Western blot analysis
Experiment for Drug Resistance	MTT assay
Mechanism Description	High miR-942 levels in MRCC cells up-regulates MMP-9 and VEGF secretion to enhance endothelial migration and sunitinib resistance.
Key Molecule: Platelet-derived growth factor receptor alpha (PDGFRA)				[1]
Resistant Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Resistant Drug	Sunitinib			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Differential expression of the molecule in resistant disease
Classification of Disease	Kidney cancer [ICD-11: 2C90]
The Specified Disease	Renal cell carcinoma
The Studied Tissue	Blood
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 2.44E-02 Fold-change: 4.10E-01 Z-score: 2.85E+00
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Caki-2 cells	Kidney	Homo sapiens (Human)	CVCL_0235
Experiment for Molecule Alteration	Western blot analysis
Experiment for Drug Resistance	MTT assay
Mechanism Description	High miR-942 levels in MRCC cells up-regulates MMP-9 and VEGF secretion to enhance endothelial migration and sunitinib resistance.
Key Molecule: Hepatocyte growth factor receptor (MET)				[6]
Resistant Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Resistant Drug	Sunitinib			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Differential expression of the molecule in resistant disease
Classification of Disease	Kidney cancer [ICD-11: 2C90]
The Specified Disease	Renal cancer
The Studied Tissue	Kidney
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 2.88E-02 Fold-change: 7.68E-02 Z-score: 2.45E+00
Experimental Note	Identified from the Human Clinical Data
Cell Pathway Regulation	ERK signaling pathway		Regulation	N.A.
	STAT3/AKT signaling pathway		Regulation	N.A.
In Vitro Model	771R-luc cells	Kidney	Homo sapiens (Human)	N.A.
Experiment for Molecule Alteration	Western blot analysis
Experiment for Drug Resistance	CCK8 assay
Mechanism Description	Exosome-Transmitted lncARSR Promotes Sunitinib Resistance in Renal Cancer by Acting as a Competing Endogenous RNA. Here we identified an LncRNA, named lncARSR (LncRNA Activated in RCC with Sunitinib Resistance), which correlated with clinically poor sunitinib response. lncARSR promoted sunitinib resistance via competitively binding miR-34/miR-449 to facilitate AXL and c-MET expression in RCC cells. Furthermore, bioactive lncARSR could be incorporated into exosomes and transmitted to sensitive cells, thus disseminating sunitinib resistance. Treatment of sunitinib-resistant RCC with locked nucleic acids targeting lncARSR or an AXL/c-MET inhibitor restored sunitinib response.
Key Molecule: Tyrosine-protein kinase UFO (AXL)				[6]
Resistant Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Resistant Drug	Sunitinib			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Differential expression of the molecule in resistant disease
Classification of Disease	Kidney cancer [ICD-11: 2C90]
The Specified Disease	Renal cancer
The Studied Tissue	Kidney
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 1.15E-02 Fold-change: 1.30E-01 Z-score: 3.05E+00
Experimental Note	Identified from the Human Clinical Data
Cell Pathway Regulation	Cell apoptosis		Inhibition	hsa04210
	Cell proliferation		Activation	hsa05200
	ERK signaling pathway		Regulation	N.A.
	STAT3/AKT signaling pathway		Regulation	N.A.
In Vitro Model	771R-luc cells	Kidney	Homo sapiens (Human)	N.A.
In Vivo Model	Nude mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	Western blot analysis
Experiment for Drug Resistance	CCK8 assay
Mechanism Description	Exosome-Transmitted lncARSR Promotes Sunitinib Resistance in Renal Cancer by Acting as a Competing Endogenous RNA. Here we identified an LncRNA, named lncARSR (LncRNA Activated in RCC with Sunitinib Resistance), which correlated with clinically poor sunitinib response. lncARSR promoted sunitinib resistance via competitively binding miR-34/miR-449 to facilitate AXL and c-MET expression in RCC cells. Furthermore, bioactive lncARSR could be incorporated into exosomes and transmitted to sensitive cells, thus disseminating sunitinib resistance. Treatment of sunitinib-resistant RCC with locked nucleic acids targeting lncARSR or an AXL/c-MET inhibitor restored sunitinib response.
Key Molecule: AT-rich interactive domain-containing protein 1A (ARID1A)				[11]
Resistant Disease	Clear cell renal cell carcinoma [ICD-11: 2C90.Y]
Resistant Drug	Sunitinib			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Differential expression of the molecule in resistant disease
Classification of Disease	Kidney cancer [ICD-11: 2C90]
The Specified Disease	Renal cancer
The Studied Tissue	Kidney
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 4.33E-04 Fold-change: -1.74E-01 Z-score: -5.03E+00
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	Cell metastasis		Activation	hsa05205
	Cell proliferation		Activation	hsa05200
	Chemoresistance		Activation	hsa05207
In Vitro Model	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Nude mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	Luciferase reporter assay; Western blot analysis; Immunohistochemical staining assay
Experiment for Drug Resistance	MTS assay
Mechanism Description	miR144-3p promotes cell proliferation, metastasis, sunitinib resistance in clear cell renal cell carcinoma by downregulating ARID1A. and the downregulation of ARIDIA could promote the function of mir144-3p in cell proliferation, metastasis and chemoresistance.
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Key Molecule: SET and MYND domain containing 2 (SMYD2)				[4]
Resistant Disease	Kidney cancer [ICD-11: 2C90.1]
Resistant Drug	Sunitinib			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Differential expression of the molecule in resistant disease
Classification of Disease	Kidney cancer [ICD-11: 2C90]
The Specified Disease	Renal cancer
The Studied Tissue	Kidney
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 8.86E-01 Fold-change: 4.00E-03 Z-score: 1.47E-01
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	HEK293T cells	Kidney	Homo sapiens (Human)	CVCL_0063
	HK-2 cells	Kidney	Homo sapiens (Human)	CVCL_0302
In Vivo Model	Balb/c athymic nude mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	Western blotting assay
Experiment for Drug Resistance	MTS assay
Mechanism Description	SMYD2 is a histone methyltransferase.The estimated IC50 values of cisplatin, doxorubicin, or 5-FU (but not docetaxel) for AZ505-treated RCC cells were significantly lower than those for the control cells, indicating that the SMYD2 inhibition enhanced the drug sensitivity in renal cancer cells.
Key Molecule: hsa-mir-130b				[20]
Resistant Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Resistant Drug	Sunitinib			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
Cell Pathway Regulation	Cell proliferation		Activation	hsa05200
In Vitro Model	Caki-1 cells	Kidney	Homo sapiens (Human)	CVCL_0234
Experiment for Molecule Alteration	qRT-PCR
Experiment for Drug Resistance	MTT assay
Mechanism Description	miR-130b promoted cell growth and was associated with sunitinib resistance through regulating PTEN expression.
Key Molecule: hsa-miR-144-3p				[11]
Resistant Disease	Clear cell renal cell carcinoma [ICD-11: 2C90.Y]
Resistant Drug	Sunitinib			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	Cell metastasis		Activation	hsa05205
	Cell proliferation		Activation	hsa05200
	Chemoresistance		Activation	hsa05207
In Vitro Model	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Nude mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	RT-qPCR
Experiment for Drug Resistance	MTS assay
Mechanism Description	miR144-3p promotes cell proliferation, metastasis, sunitinib resistance in clear cell renal cell carcinoma by downregulating ARID1A. and the downregulation of ARIDIA could promote the function of mir144-3p in cell proliferation, metastasis and chemoresistance.
Key Molecule: Long non-protein coding RNA SARCC(SARCC)				[21]
Resistant Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Resistant Drug	Sunitinib			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	Cell adhesion		Inhibition	hsa04514
	Cell apoptosis		Inhibition	hsa04210
In Vitro Model	Caki-1 cells	Kidney	Homo sapiens (Human)	CVCL_0234
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	A498 cells	Kidney	Homo sapiens (Human)	CVCL_1056
	Caki-2 cells	Kidney	Homo sapiens (Human)	CVCL_0235
	Hk-2 cells	Kidney	Homo sapiens (Human)	CVCL_0302
	OSRC-2 cells	Kidney	Homo sapiens (Human)	CVCL_1626
	SW839 cells	Kidney	Homo sapiens (Human)	CVCL_3604
In Vivo Model	Nude mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qPCR
Experiment for Drug Resistance	MTT assay; Wound-healing assay; Transwell assay
Mechanism Description	LncRNA-SARCC bound and destabilized AR protein with an inhibition of AR function, which led to transcriptionally de-repress miR143-3p expression, thus inhibition of its downstream signals including AkT, MMP-13, k-RAS and P-ERk. Increased the expression of LncRNA-SARCC decreased RCC cells resistance to Sunitinib.
Key Molecule: hsa-miR-143-3p				[21]
Resistant Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Resistant Drug	Sunitinib			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	Cancer progression		Inhibition	hsa05200
In Vitro Model	Caki-1 cells	Kidney	Homo sapiens (Human)	CVCL_0234
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	A498 cells	Kidney	Homo sapiens (Human)	CVCL_1056
	Caki-2 cells	Kidney	Homo sapiens (Human)	CVCL_0235
	Hk-2 cells	Kidney	Homo sapiens (Human)	CVCL_0302
	OSRC-2 cells	Kidney	Homo sapiens (Human)	CVCL_1626
	SW839 cells	Kidney	Homo sapiens (Human)	CVCL_3604
In Vivo Model	Nude mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; RNA pull-down assay; ChIP assay
Experiment for Drug Resistance	MTT assay; Wound-healing assay; Transwell assay
Mechanism Description	LncRNA-SARCC bound and destabilized AR protein with an inhibition of AR function, which led to transcriptionally de-repress miR143-3p expression, thus inhibition of its downstream signals including AkT, MMP-13, k-RAS and P-ERk. Increased the expression of LncRNA-SARCC decreased RCC cells resistance to Sunitinib.
Key Molecule: LncRNA regulator of Akt signaling associated with HCC and RCC (LNCARSR)				[6]
Resistant Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Resistant Drug	Sunitinib			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
Cell Pathway Regulation	Cell apoptosis		Inhibition	hsa04210
	Cell proliferation		Activation	hsa05200
	ERK signaling pathway		Regulation	N.A.
	STAT3/AKT signaling pathway		Regulation	N.A.
In Vitro Model	771R-luc cells	Kidney	Homo sapiens (Human)	N.A.
Experiment for Molecule Alteration	qPCR; Northern blot analysis
Experiment for Drug Resistance	CCK8 assay
Mechanism Description	Exosome-Transmitted lncARSR Promotes Sunitinib Resistance in Renal Cancer by Acting as a Competing Endogenous RNA. Here we identified an LncRNA, named lncARSR (LncRNA Activated in RCC with Sunitinib Resistance), which correlated with clinically poor sunitinib response. lncARSR promoted sunitinib resistance via competitively binding miR-34/miR-449 to facilitate AXL and c-MET expression in RCC cells. Furthermore, bioactive lncARSR could be incorporated into exosomes and transmitted to sensitive cells, thus disseminating sunitinib resistance. Treatment of sunitinib-resistant RCC with locked nucleic acids targeting lncARSR or an AXL/c-MET inhibitor restored sunitinib response.
Key Molecule: hsa-mir-133a				[1]
Resistant Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Resistant Drug	Sunitinib			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
Cell Pathway Regulation	Cell migration		Activation	hsa04670
In Vitro Model	Caki-2 cells	Kidney	Homo sapiens (Human)	CVCL_0235
Experiment for Molecule Alteration	qRT-PCR
Experiment for Drug Resistance	MTT assay
Mechanism Description	High expression of miR-942, miR-628-5p, miR-133a, and miR-484 was significantly associated with decreased time to progression and overall survival. These microRNAs were also overexpressed in the sunitinib resistant cell line Caki-2 in comparison with the sensitive cell line.
Key Molecule: hsa-miR-484				[1]
Resistant Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Resistant Drug	Sunitinib			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
Cell Pathway Regulation	Cell migration		Activation	hsa04670
In Vitro Model	Caki-2 cells	Kidney	Homo sapiens (Human)	CVCL_0235
Experiment for Molecule Alteration	qRT-PCR
Experiment for Drug Resistance	MTT assay
Mechanism Description	High expression of miR-942, miR-628-5p, miR-133a, and miR-484 was significantly associated with decreased time to progression and overall survival. These microRNAs were also overexpressed in the sunitinib resistant cell line Caki-2 in comparison with the sensitive cell line.
Key Molecule: hsa-miR-628-5p				[1]
Resistant Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Resistant Drug	Sunitinib			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
Cell Pathway Regulation	Cell migration		Activation	hsa04670
In Vitro Model	Caki-2 cells	Kidney	Homo sapiens (Human)	CVCL_0235
Experiment for Molecule Alteration	qRT-PCR
Experiment for Drug Resistance	MTT assay
Mechanism Description	High expression of miR-942, miR-628-5p, miR-133a, and miR-484 was significantly associated with decreased time to progression and overall survival. These microRNAs were also overexpressed in the sunitinib resistant cell line Caki-2 in comparison with the sensitive cell line.
Key Molecule: hsa-mir-942				[1]
Resistant Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Resistant Drug	Sunitinib			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Caki-2 cells	Kidney	Homo sapiens (Human)	CVCL_0235
Experiment for Molecule Alteration	qRT-PCR
Experiment for Drug Resistance	MTT assay
Mechanism Description	High miR-942 levels in MRCC cells up-regulates MMP-9 and VEGF secretion to enhance endothelial migration and sunitinib resistance.
Key Molecule: hsa-miR-199a-1				[22]
Resistant Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Resistant Drug	Sunitinib			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
In Vivo Model	Advanced renal cell carcinoma patients			Homo sapiens
Experiment for Molecule Alteration	RT-PCR
Mechanism Description	Blood samples from 38 patients and 287 miRNAs were evaluated. Twenty-eight miRNAs of the 287 were related to poor response and 23 of the 287 were related to prolonged response to sunitinib treatment. Predictive models identified populations with differences in the established end points.
Key Molecule: hsa-miR-362				[22]
Resistant Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Resistant Drug	Sunitinib			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
In Vivo Model	Advanced renal cell carcinoma patients			Homo sapiens
Experiment for Molecule Alteration	RT-PCR
Mechanism Description	Blood samples from 38 patients and 287 miRNAs were evaluated. Twenty-eight miRNAs of the 287 were related to poor response and 23 of the 287 were related to prolonged response to sunitinib treatment. Predictive models identified populations with differences in the established end points.
Key Molecule: hsa-miR-1825				[22]
Resistant Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Resistant Drug	Sunitinib			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
In Vivo Model	Advanced renal cell carcinoma patients			Homo sapiens
Experiment for Molecule Alteration	RT-PCR
Mechanism Description	Blood samples from 38 patients and 287 miRNAs were evaluated. Twenty-eight miRNAs of the 287 were related to poor response and 23 of the 287 were related to prolonged response to sunitinib treatment. Predictive models identified populations with differences in the established end points.
Key Molecule: hsa-miR-933				[22]
Resistant Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Resistant Drug	Sunitinib			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
In Vivo Model	Advanced renal cell carcinoma patients			Homo sapiens
Experiment for Molecule Alteration	RT-PCR
Mechanism Description	Blood samples from 38 patients and 287 miRNAs were evaluated. Twenty-eight miRNAs of the 287 were related to poor response and 23 of the 287 were related to prolonged response to sunitinib treatment. Predictive models identified populations with differences in the established end points.
Key Molecule: hsa-miR-659				[22]
Resistant Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Resistant Drug	Sunitinib			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
In Vivo Model	Advanced renal cell carcinoma patients			Homo sapiens
Experiment for Molecule Alteration	RT-PCR
Mechanism Description	Blood samples from 38 patients and 287 miRNAs were evaluated. Twenty-eight miRNAs of the 287 were related to poor response and 23 of the 287 were related to prolonged response to sunitinib treatment. Predictive models identified populations with differences in the established end points.
Key Molecule: hsa-miR-624				[22]
Resistant Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Resistant Drug	Sunitinib			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
In Vivo Model	Advanced renal cell carcinoma patients			Homo sapiens
Experiment for Molecule Alteration	RT-PCR
Mechanism Description	Blood samples from 38 patients and 287 miRNAs were evaluated. Twenty-eight miRNAs of the 287 were related to poor response and 23 of the 287 were related to prolonged response to sunitinib treatment. Predictive models identified populations with differences in the established end points.
Key Molecule: hsa-miR-582				[22]
Resistant Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Resistant Drug	Sunitinib			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
In Vivo Model	Advanced renal cell carcinoma patients			Homo sapiens
Experiment for Molecule Alteration	RT-PCR
Mechanism Description	Blood samples from 38 patients and 287 miRNAs were evaluated. Twenty-eight miRNAs of the 287 were related to poor response and 23 of the 287 were related to prolonged response to sunitinib treatment. Predictive models identified populations with differences in the established end points.
Key Molecule: hsa-miR-564				[22]
Resistant Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Resistant Drug	Sunitinib			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
In Vivo Model	Advanced renal cell carcinoma patients			Homo sapiens
Experiment for Molecule Alteration	RT-PCR
Mechanism Description	Blood samples from 38 patients and 287 miRNAs were evaluated. Twenty-eight miRNAs of the 287 were related to poor response and 23 of the 287 were related to prolonged response to sunitinib treatment. Predictive models identified populations with differences in the established end points.
Key Molecule: hsa-miR-501				[22]
Resistant Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Resistant Drug	Sunitinib			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
In Vivo Model	Advanced renal cell carcinoma patients			Homo sapiens
Experiment for Molecule Alteration	RT-PCR
Mechanism Description	Blood samples from 38 patients and 287 miRNAs were evaluated. Twenty-eight miRNAs of the 287 were related to poor response and 23 of the 287 were related to prolonged response to sunitinib treatment. Predictive models identified populations with differences in the established end points.
Key Molecule: hsa-miR-516a-1				[22]
Resistant Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Resistant Drug	Sunitinib			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
In Vivo Model	Advanced renal cell carcinoma patients			Homo sapiens
Experiment for Molecule Alteration	RT-PCR
Mechanism Description	Blood samples from 38 patients and 287 miRNAs were evaluated. Twenty-eight miRNAs of the 287 were related to poor response and 23 of the 287 were related to prolonged response to sunitinib treatment. Predictive models identified populations with differences in the established end points.
Key Molecule: hsa-miR-29a				[22]
Resistant Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Resistant Drug	Sunitinib			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
In Vivo Model	Advanced renal cell carcinoma patients			Homo sapiens
Experiment for Molecule Alteration	RT-PCR
Mechanism Description	Blood samples from 38 patients and 287 miRNAs were evaluated. Twenty-eight miRNAs of the 287 were related to poor response and 23 of the 287 were related to prolonged response to sunitinib treatment. Predictive models identified populations with differences in the established end points.
Key Molecule: hsa-miR-31				[22]
Resistant Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Resistant Drug	Sunitinib			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
In Vivo Model	Advanced renal cell carcinoma patients			Homo sapiens
Experiment for Molecule Alteration	RT-PCR
Mechanism Description	Blood samples from 38 patients and 287 miRNAs were evaluated. Twenty-eight miRNAs of the 287 were related to poor response and 23 of the 287 were related to prolonged response to sunitinib treatment. Predictive models identified populations with differences in the established end points.
Key Molecule: hsa-miR-192				[22]
Resistant Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Resistant Drug	Sunitinib			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
In Vivo Model	Advanced renal cell carcinoma patients			Homo sapiens
Experiment for Molecule Alteration	RT-PCR
Mechanism Description	Blood samples from 38 patients and 287 miRNAs were evaluated. Twenty-eight miRNAs of the 287 were related to poor response and 23 of the 287 were related to prolonged response to sunitinib treatment. Predictive models identified populations with differences in the established end points.
Key Molecule: hsa-miR-139				[22]
Resistant Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Resistant Drug	Sunitinib			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
In Vivo Model	Advanced renal cell carcinoma patients			Homo sapiens
Experiment for Molecule Alteration	RT-PCR
Mechanism Description	Blood samples from 38 patients and 287 miRNAs were evaluated. Twenty-eight miRNAs of the 287 were related to poor response and 23 of the 287 were related to prolonged response to sunitinib treatment. Predictive models identified populations with differences in the established end points.
Key Molecule: hsa-miR-34a				[22]
Resistant Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Resistant Drug	Sunitinib			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
In Vivo Model	Advanced renal cell carcinoma patients			Homo sapiens
Experiment for Molecule Alteration	RT-PCR
Mechanism Description	Blood samples from 38 patients and 287 miRNAs were evaluated. Twenty-eight miRNAs of the 287 were related to poor response and 23 of the 287 were related to prolonged response to sunitinib treatment. Predictive models identified populations with differences in the established end points.
Key Molecule: hsa-miR-30b				[22]
Resistant Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Resistant Drug	Sunitinib			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
In Vivo Model	Advanced renal cell carcinoma patients			Homo sapiens
Experiment for Molecule Alteration	RT-PCR
Mechanism Description	Blood samples from 38 patients and 287 miRNAs were evaluated. Twenty-eight miRNAs of the 287 were related to poor response and 23 of the 287 were related to prolonged response to sunitinib treatment. Predictive models identified populations with differences in the established end points.
Key Molecule: hsa-miR-145				[22]
Resistant Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Resistant Drug	Sunitinib			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
In Vivo Model	Advanced renal cell carcinoma patients			Homo sapiens
Experiment for Molecule Alteration	RT-PCR
Mechanism Description	Blood samples from 38 patients and 287 miRNAs were evaluated. Twenty-eight miRNAs of the 287 were related to poor response and 23 of the 287 were related to prolonged response to sunitinib treatment. Predictive models identified populations with differences in the established end points.
Key Molecule: hsa-miR-150				[22]
Resistant Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Resistant Drug	Sunitinib			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
In Vivo Model	Advanced renal cell carcinoma patients			Homo sapiens
Experiment for Molecule Alteration	RT-PCR
Mechanism Description	Blood samples from 38 patients and 287 miRNAs were evaluated. Twenty-eight miRNAs of the 287 were related to poor response and 23 of the 287 were related to prolonged response to sunitinib treatment. Predictive models identified populations with differences in the established end points.
Key Molecule: hsa-miR-193a				[22]
Resistant Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Resistant Drug	Sunitinib			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
In Vivo Model	Advanced renal cell carcinoma patients			Homo sapiens
Experiment for Molecule Alteration	RT-PCR
Mechanism Description	Blood samples from 38 patients and 287 miRNAs were evaluated. Twenty-eight miRNAs of the 287 were related to poor response and 23 of the 287 were related to prolonged response to sunitinib treatment. Predictive models identified populations with differences in the established end points.
Key Molecule: hsa-miR-370				[22]
Resistant Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Resistant Drug	Sunitinib			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
In Vivo Model	Advanced renal cell carcinoma patients			Homo sapiens
Experiment for Molecule Alteration	RT-PCR
Mechanism Description	Blood samples from 38 patients and 287 miRNAs were evaluated. Twenty-eight miRNAs of the 287 were related to poor response and 23 of the 287 were related to prolonged response to sunitinib treatment. Predictive models identified populations with differences in the established end points.
Key Molecule: hsa-miR-505				[22]
Resistant Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Resistant Drug	Sunitinib			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
In Vivo Model	Advanced renal cell carcinoma patients			Homo sapiens
Experiment for Molecule Alteration	RT-PCR
Mechanism Description	Blood samples from 38 patients and 287 miRNAs were evaluated. Twenty-eight miRNAs of the 287 were related to poor response and 23 of the 287 were related to prolonged response to sunitinib treatment. Predictive models identified populations with differences in the established end points.
Key Molecule: hsa-miR-629				[22]
Resistant Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Resistant Drug	Sunitinib			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
In Vivo Model	Advanced renal cell carcinoma patients			Homo sapiens
Experiment for Molecule Alteration	RT-PCR
Mechanism Description	Blood samples from 38 patients and 287 miRNAs were evaluated. Twenty-eight miRNAs of the 287 were related to poor response and 23 of the 287 were related to prolonged response to sunitinib treatment. Predictive models identified populations with differences in the established end points.

Paclitaxel

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Unusual Activation of Pro-survival Pathway (UAPP)			Click to Show/Hide
Key Molecule: Metalloproteinase inhibitor 3 (TIMP3)				[2]
Sensitive Disease	Renal carcinoma [ICD-11: 2C90.2]
Sensitive Drug	Paclitaxel			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Differential expression of the molecule in resistant disease
Classification of Disease	Kidney cancer [ICD-11: 2C90]
The Specified Disease	Renal carcinoma
The Studied Tissue	Blood
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 1.59E-02 Fold-change: 2.68E+00 Z-score: 3.16E+00
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	PI3K/AKT signaling pathway		Inhibition	hsa04151
In Vitro Model	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
	ACHN cells	Pleural effusion	Homo sapiens (Human)	CVCL_1067
	HK-2 cells	Kidney	Homo sapiens (Human)	CVCL_0302
	RCC10 cells	Kidney	Homo sapiens (Human)	CVCL_6265
	RCC4 cells	Kidney	Homo sapiens (Human)	CVCL_0498
Experiment for Molecule Alteration	Western blot analysis
Experiment for Drug Resistance	Celltiter96 Aqueous Non Radioactive Cell Proliferation Assay
Mechanism Description	Tumor suppressor genes like PTEN, PDCD4 and TIMP3, are target genes of miR21. PTEN is a potent inhibitor of PI3k/Akt pathway, as well as a direct target of miR21.
Key Molecule: Programmed cell death protein 4 (PDCD4)				[2]
Sensitive Disease	Renal carcinoma [ICD-11: 2C90.2]
Sensitive Drug	Paclitaxel			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Differential expression of the molecule in resistant disease
Classification of Disease	Kidney cancer [ICD-11: 2C90]
The Specified Disease	Renal carcinoma
The Studied Tissue	Kidney
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 8.62E-01 Fold-change: 6.66E-03 Z-score: 1.74E-01
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	PI3K/AKT signaling pathway		Inhibition	hsa04151
In Vitro Model	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
	ACHN cells	Pleural effusion	Homo sapiens (Human)	CVCL_1067
	HK-2 cells	Kidney	Homo sapiens (Human)	CVCL_0302
	RCC10 cells	Kidney	Homo sapiens (Human)	CVCL_6265
	RCC4 cells	Kidney	Homo sapiens (Human)	CVCL_0498
Experiment for Molecule Alteration	Western blot analysis
Experiment for Drug Resistance	Celltiter96 Aqueous Non Radioactive Cell Proliferation Assay
Mechanism Description	Tumor suppressor genes like PTEN, PDCD4 and TIMP3, are target genes of miR21. PTEN is a potent inhibitor of PI3k/Akt pathway, as well as a direct target of miR21.
Key Molecule: Phosphatase and tensin homolog (PTEN)				[2]
Sensitive Disease	Renal carcinoma [ICD-11: 2C90.2]
Sensitive Drug	Paclitaxel			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Differential expression of the molecule in resistant disease
Classification of Disease	Kidney cancer [ICD-11: 2C90]
The Specified Disease	Renal cancer
The Studied Tissue	Kidney
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 3.24E-05 Fold-change: 1.07E-01 Z-score: 6.36E+00
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	PI3K/AKT signaling pathway		Inhibition	hsa04151
In Vitro Model	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
	ACHN cells	Pleural effusion	Homo sapiens (Human)	CVCL_1067
	HK-2 cells	Kidney	Homo sapiens (Human)	CVCL_0302
	RCC10 cells	Kidney	Homo sapiens (Human)	CVCL_6265
	RCC4 cells	Kidney	Homo sapiens (Human)	CVCL_0498
Experiment for Molecule Alteration	Western blot analysis
Experiment for Drug Resistance	Celltiter96 Aqueous Non Radioactive Cell Proliferation Assay
Mechanism Description	Tumor suppressor genes like PTEN, PDCD4 and TIMP3, are target genes of miR21. PTEN is a potent inhibitor of PI3k/Akt pathway, as well as a direct target of miR21.
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Key Molecule: hsa-mir-21				[2]
Sensitive Disease	Renal carcinoma [ICD-11: 2C90.2]
Sensitive Drug	Paclitaxel			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	PI3K/AKT signaling pathway		Inhibition	hsa04151
In Vitro Model	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
	ACHN cells	Pleural effusion	Homo sapiens (Human)	CVCL_1067
	HK-2 cells	Kidney	Homo sapiens (Human)	CVCL_0302
	RCC10 cells	Kidney	Homo sapiens (Human)	CVCL_6265
	RCC4 cells	Kidney	Homo sapiens (Human)	CVCL_0498
Experiment for Molecule Alteration	qPCR
Experiment for Drug Resistance	Celltiter96 Aqueous Non Radioactive Cell Proliferation Assay
Mechanism Description	Tumor suppressor genes like PTEN, PDCD4 and TIMP3, are target genes of miR21. PTEN is a potent inhibitor of PI3k/Akt pathway, as well as a direct target of miR21.

Oxaliplatin

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Unusual Activation of Pro-survival Pathway (UAPP)			Click to Show/Hide
Key Molecule: Metalloproteinase inhibitor 3 (TIMP3)				[2]
Sensitive Disease	Renal carcinoma [ICD-11: 2C90.2]
Sensitive Drug	Oxaliplatin			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Differential expression of the molecule in resistant disease
Classification of Disease	Kidney cancer [ICD-11: 2C90]
The Specified Disease	Renal carcinoma
The Studied Tissue	Blood
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 1.59E-02 Fold-change: 2.68E+00 Z-score: 3.16E+00
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	PI3K/AKT signaling pathway		Inhibition	hsa04151
In Vitro Model	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
	ACHN cells	Pleural effusion	Homo sapiens (Human)	CVCL_1067
	HK-2 cells	Kidney	Homo sapiens (Human)	CVCL_0302
	RCC10 cells	Kidney	Homo sapiens (Human)	CVCL_6265
	RCC4 cells	Kidney	Homo sapiens (Human)	CVCL_0498
Experiment for Molecule Alteration	Western blot analysis
Experiment for Drug Resistance	Celltiter96 Aqueous Non Radioactive Cell Proliferation Assay
Mechanism Description	Tumor suppressor genes like PTEN, PDCD4 and TIMP3, are target genes of miR21. PTEN is a potent inhibitor of PI3k/Akt pathway, as well as a direct target of miR21.
Key Molecule: Programmed cell death protein 4 (PDCD4)				[2]
Sensitive Disease	Renal carcinoma [ICD-11: 2C90.2]
Sensitive Drug	Oxaliplatin			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Differential expression of the molecule in resistant disease
Classification of Disease	Kidney cancer [ICD-11: 2C90]
The Specified Disease	Renal carcinoma
The Studied Tissue	Kidney
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 8.62E-01 Fold-change: 6.66E-03 Z-score: 1.74E-01
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	PI3K/AKT signaling pathway		Inhibition	hsa04151
In Vitro Model	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
	ACHN cells	Pleural effusion	Homo sapiens (Human)	CVCL_1067
	HK-2 cells	Kidney	Homo sapiens (Human)	CVCL_0302
	RCC10 cells	Kidney	Homo sapiens (Human)	CVCL_6265
	RCC4 cells	Kidney	Homo sapiens (Human)	CVCL_0498
Experiment for Molecule Alteration	Western blot analysis
Experiment for Drug Resistance	Celltiter96 Aqueous Non Radioactive Cell Proliferation Assay
Mechanism Description	Tumor suppressor genes like PTEN, PDCD4 and TIMP3, are target genes of miR21. PTEN is a potent inhibitor of PI3k/Akt pathway, as well as a direct target of miR21.
Key Molecule: Phosphatase and tensin homolog (PTEN)				[2]
Sensitive Disease	Renal carcinoma [ICD-11: 2C90.2]
Sensitive Drug	Oxaliplatin			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	PI3K/AKT signaling pathway		Inhibition	hsa04151
In Vitro Model	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
	ACHN cells	Pleural effusion	Homo sapiens (Human)	CVCL_1067
	HK-2 cells	Kidney	Homo sapiens (Human)	CVCL_0302
	RCC10 cells	Kidney	Homo sapiens (Human)	CVCL_6265
	RCC4 cells	Kidney	Homo sapiens (Human)	CVCL_0498
Experiment for Molecule Alteration	Western blot analysis
Experiment for Drug Resistance	Celltiter96 Aqueous Non Radioactive Cell Proliferation Assay
Mechanism Description	Tumor suppressor genes like PTEN, PDCD4 and TIMP3, are target genes of miR21. PTEN is a potent inhibitor of PI3k/Akt pathway, as well as a direct target of miR21.
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Key Molecule: hsa-mir-21				[2]
Sensitive Disease	Renal carcinoma [ICD-11: 2C90.2]
Sensitive Drug	Oxaliplatin			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	PI3K/AKT signaling pathway		Inhibition	hsa04151
In Vitro Model	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
	ACHN cells	Pleural effusion	Homo sapiens (Human)	CVCL_1067
	HK-2 cells	Kidney	Homo sapiens (Human)	CVCL_0302
	RCC10 cells	Kidney	Homo sapiens (Human)	CVCL_6265
	RCC4 cells	Kidney	Homo sapiens (Human)	CVCL_0498
Experiment for Molecule Alteration	qPCR
Experiment for Drug Resistance	Celltiter96 Aqueous Non Radioactive Cell Proliferation Assay
Mechanism Description	Tumor suppressor genes like PTEN, PDCD4 and TIMP3, are target genes of miR21. PTEN is a potent inhibitor of PI3k/Akt pathway, as well as a direct target of miR21.

Fluorouracil

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Unusual Activation of Pro-survival Pathway (UAPP)			Click to Show/Hide
Key Molecule: Metalloproteinase inhibitor 3 (TIMP3)				[2]
Sensitive Disease	Renal carcinoma [ICD-11: 2C90.2]
Sensitive Drug	Fluorouracil			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Differential expression of the molecule in resistant disease
Classification of Disease	Kidney cancer [ICD-11: 2C90]
The Specified Disease	Renal carcinoma
The Studied Tissue	Blood
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 1.59E-02 Fold-change: 2.68E+00 Z-score: 3.16E+00
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	PI3K/AKT signaling pathway		Inhibition	hsa04151
In Vitro Model	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
	ACHN cells	Pleural effusion	Homo sapiens (Human)	CVCL_1067
	HK-2 cells	Kidney	Homo sapiens (Human)	CVCL_0302
	RCC10 cells	Kidney	Homo sapiens (Human)	CVCL_6265
	RCC4 cells	Kidney	Homo sapiens (Human)	CVCL_0498
Experiment for Molecule Alteration	Western blot analysis
Experiment for Drug Resistance	Celltiter96 Aqueous Non Radioactive Cell Proliferation Assay
Mechanism Description	Tumor suppressor genes like PTEN, PDCD4 and TIMP3, are target genes of miR21. PTEN is a potent inhibitor of PI3k/Akt pathway, as well as a direct target of miR21.
Key Molecule: Wee1-like protein kinase (WEE1)				[5]
Sensitive Disease	Kidney cancer [ICD-11: 2C90.1]
Sensitive Drug	Fluorouracil			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Differential expression of the molecule in resistant disease
Classification of Disease	Kidney cancer [ICD-11: 2C90]
The Specified Disease	Kidney cancer
The Studied Tissue	Kidney
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 1.32E-08 Fold-change: -6.91E-01 Z-score: -6.01E+00
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	Cell apoptosis		Activation	hsa04210
	Cell proliferation		Inhibition	hsa05200
	WEE1/Cdc2 signaling pathway		Activation	hsa04110
In Vitro Model	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
	HK-2 cells	Kidney	Homo sapiens (Human)	CVCL_0302
Experiment for Molecule Alteration	Western blot analysis
Experiment for Drug Resistance	MTT assay
Mechanism Description	miR-381 increases sensitivity of 786-O cells to 5-FU by inhibitory WEE1 and increase of Cdc2activity.
Key Molecule: Programmed cell death protein 4 (PDCD4)				[2]
Sensitive Disease	Renal carcinoma [ICD-11: 2C90.2]
Sensitive Drug	Fluorouracil			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Differential expression of the molecule in resistant disease
Classification of Disease	Kidney cancer [ICD-11: 2C90]
The Specified Disease	Renal carcinoma
The Studied Tissue	Kidney
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 8.62E-01 Fold-change: 6.66E-03 Z-score: 1.74E-01
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	PI3K/AKT signaling pathway		Inhibition	hsa04151
In Vitro Model	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
	ACHN cells	Pleural effusion	Homo sapiens (Human)	CVCL_1067
	HK-2 cells	Kidney	Homo sapiens (Human)	CVCL_0302
	RCC10 cells	Kidney	Homo sapiens (Human)	CVCL_6265
	RCC4 cells	Kidney	Homo sapiens (Human)	CVCL_0498
Experiment for Molecule Alteration	Western blot analysis
Experiment for Drug Resistance	Celltiter96 Aqueous Non Radioactive Cell Proliferation Assay
Mechanism Description	Tumor suppressor genes like PTEN, PDCD4 and TIMP3, are target genes of miR21. PTEN is a potent inhibitor of PI3k/Akt pathway, as well as a direct target of miR21.
Key Molecule: Phosphatase and tensin homolog (PTEN)				[2]
Sensitive Disease	Renal carcinoma [ICD-11: 2C90.2]
Sensitive Drug	Fluorouracil			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	PI3K/AKT signaling pathway		Inhibition	hsa04151
In Vitro Model	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
	ACHN cells	Pleural effusion	Homo sapiens (Human)	CVCL_1067
	HK-2 cells	Kidney	Homo sapiens (Human)	CVCL_0302
	RCC10 cells	Kidney	Homo sapiens (Human)	CVCL_6265
	RCC4 cells	Kidney	Homo sapiens (Human)	CVCL_0498
Experiment for Molecule Alteration	Western blot analysis
Experiment for Drug Resistance	Celltiter96 Aqueous Non Radioactive Cell Proliferation Assay
Mechanism Description	Tumor suppressor genes like PTEN, PDCD4 and TIMP3, are target genes of miR21. PTEN is a potent inhibitor of PI3k/Akt pathway, as well as a direct target of miR21.
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Key Molecule: hsa-mir-21				[2]
Sensitive Disease	Renal carcinoma [ICD-11: 2C90.2]
Sensitive Drug	Fluorouracil			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	PI3K/AKT signaling pathway		Inhibition	hsa04151
In Vitro Model	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
	ACHN cells	Pleural effusion	Homo sapiens (Human)	CVCL_1067
	HK-2 cells	Kidney	Homo sapiens (Human)	CVCL_0302
	RCC10 cells	Kidney	Homo sapiens (Human)	CVCL_6265
	RCC4 cells	Kidney	Homo sapiens (Human)	CVCL_0498
Experiment for Molecule Alteration	qPCR
Experiment for Drug Resistance	Celltiter96 Aqueous Non Radioactive Cell Proliferation Assay
Mechanism Description	Tumor suppressor genes like PTEN, PDCD4 and TIMP3, are target genes of miR21. PTEN is a potent inhibitor of PI3k/Akt pathway, as well as a direct target of miR21.
Key Molecule: hsa-mir-381				[5]
Sensitive Disease	Kidney cancer [ICD-11: 2C90.1]
Sensitive Drug	Fluorouracil			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	Cell apoptosis		Activation	hsa04210
	Cell colony		Inhibition	hsa05200
	Cell proliferation		Inhibition	hsa05200
	WEE1/Cdc2 signaling pathway		Activation	hsa04110
In Vitro Model	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
	HK-2 cells	Kidney	Homo sapiens (Human)	CVCL_0302
Experiment for Molecule Alteration	RT-PCR
Experiment for Drug Resistance	MTT assay
Mechanism Description	miR-381 increases sensitivity of 786-O cells to 5-FU by inhibitory WEE1 and increase of Cdc2activity.

Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Key Molecule: SET and MYND domain containing 2 (SMYD2)				[4]
Resistant Disease	Kidney cancer [ICD-11: 2C90.1]
Resistant Drug	Fluorouracil			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Differential expression of the molecule in resistant disease
Classification of Disease	Kidney cancer [ICD-11: 2C90]
The Specified Disease	Kidney cancer
The Studied Tissue	Kidney
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 8.07E-35 Fold-change: 6.59E-01 Z-score: 1.61E+01
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	HEK293T cells	Kidney	Homo sapiens (Human)	CVCL_0063
	HK-2 cells	Kidney	Homo sapiens (Human)	CVCL_0302
In Vivo Model	Balb/c athymic nude mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	Western blotting assay
Experiment for Drug Resistance	MTS assay
Mechanism Description	SMYD2 is a histone methyltransferase.The estimated IC50 values of cisplatin, doxorubicin, or 5-FU (but not docetaxel) for AZ505-treated RCC cells were significantly lower than those for the control cells, indicating that the SMYD2 inhibition enhanced the drug sensitivity in renal cancer cells.

Dovitinib lactate

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Unusual Activation of Pro-survival Pathway (UAPP)			Click to Show/Hide
Key Molecule: Metalloproteinase inhibitor 3 (TIMP3)				[2]
Sensitive Disease	Renal carcinoma [ICD-11: 2C90.2]
Sensitive Drug	Dovitinib lactate			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Differential expression of the molecule in resistant disease
Classification of Disease	Kidney cancer [ICD-11: 2C90]
The Specified Disease	Renal carcinoma
The Studied Tissue	Blood
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 1.59E-02 Fold-change: 2.68E+00 Z-score: 3.16E+00
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	PI3K/AKT signaling pathway		Inhibition	hsa04151
In Vitro Model	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
	ACHN cells	Pleural effusion	Homo sapiens (Human)	CVCL_1067
	HK-2 cells	Kidney	Homo sapiens (Human)	CVCL_0302
	RCC10 cells	Kidney	Homo sapiens (Human)	CVCL_6265
	RCC4 cells	Kidney	Homo sapiens (Human)	CVCL_0498
Experiment for Molecule Alteration	Western blot analysis
Experiment for Drug Resistance	Celltiter96 Aqueous Non Radioactive Cell Proliferation Assay
Mechanism Description	Tumor suppressor genes like PTEN, PDCD4 and TIMP3, are target genes of miR21. PTEN is a potent inhibitor of PI3k/Akt pathway, as well as a direct target of miR21.
Key Molecule: Programmed cell death protein 4 (PDCD4)				[2]
Sensitive Disease	Renal carcinoma [ICD-11: 2C90.2]
Sensitive Drug	Dovitinib lactate			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Differential expression of the molecule in resistant disease
Classification of Disease	Kidney cancer [ICD-11: 2C90]
The Specified Disease	Renal carcinoma
The Studied Tissue	Kidney
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 8.62E-01 Fold-change: 6.66E-03 Z-score: 1.74E-01
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	PI3K/AKT signaling pathway		Inhibition	hsa04151
In Vitro Model	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
	ACHN cells	Pleural effusion	Homo sapiens (Human)	CVCL_1067
	HK-2 cells	Kidney	Homo sapiens (Human)	CVCL_0302
	RCC10 cells	Kidney	Homo sapiens (Human)	CVCL_6265
	RCC4 cells	Kidney	Homo sapiens (Human)	CVCL_0498
Experiment for Molecule Alteration	Western blot analysis
Experiment for Drug Resistance	Celltiter96 Aqueous Non Radioactive Cell Proliferation Assay
Mechanism Description	Tumor suppressor genes like PTEN, PDCD4 and TIMP3, are target genes of miR21. PTEN is a potent inhibitor of PI3k/Akt pathway, as well as a direct target of miR21.
Key Molecule: Phosphatase and tensin homolog (PTEN)				[2]
Sensitive Disease	Renal carcinoma [ICD-11: 2C90.2]
Sensitive Drug	Dovitinib lactate			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	PI3K/AKT signaling pathway		Inhibition	hsa04151
In Vitro Model	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
	ACHN cells	Pleural effusion	Homo sapiens (Human)	CVCL_1067
	HK-2 cells	Kidney	Homo sapiens (Human)	CVCL_0302
	RCC10 cells	Kidney	Homo sapiens (Human)	CVCL_6265
	RCC4 cells	Kidney	Homo sapiens (Human)	CVCL_0498
Experiment for Molecule Alteration	Western blot analysis
Experiment for Drug Resistance	Celltiter96 Aqueous Non Radioactive Cell Proliferation Assay
Mechanism Description	Tumor suppressor genes like PTEN, PDCD4 and TIMP3, are target genes of miR21. PTEN is a potent inhibitor of PI3k/Akt pathway, as well as a direct target of miR21.
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Key Molecule: hsa-mir-21				[2]
Sensitive Disease	Renal carcinoma [ICD-11: 2C90.2]
Sensitive Drug	Dovitinib lactate			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	PI3K/AKT signaling pathway		Inhibition	hsa04151
In Vitro Model	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
	ACHN cells	Pleural effusion	Homo sapiens (Human)	CVCL_1067
	HK-2 cells	Kidney	Homo sapiens (Human)	CVCL_0302
	RCC10 cells	Kidney	Homo sapiens (Human)	CVCL_6265
	RCC4 cells	Kidney	Homo sapiens (Human)	CVCL_0498
Experiment for Molecule Alteration	qPCR
Experiment for Drug Resistance	Celltiter96 Aqueous Non Radioactive Cell Proliferation Assay
Mechanism Description	Tumor suppressor genes like PTEN, PDCD4 and TIMP3, are target genes of miR21. PTEN is a potent inhibitor of PI3k/Akt pathway, as well as a direct target of miR21.

Vinblastine

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Irregularity in Drug Uptake and Drug Efflux (IDUE)			Click to Show/Hide
Key Molecule: Multidrug resistance protein 1 (ABCB1)				[3]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Vinblastine			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Differential expression of the molecule in resistant disease
Classification of Disease	Kidney cancer [ICD-11: 2C90]
The Specified Disease	Renal cell carcinoma
The Studied Tissue	Kidney
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 4.11E-46 Fold-change: -1.42E+00 Z-score: -1.91E+01
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	Flp-In-293/Mock cells	Kidney	Homo sapiens (Human)	CVCL_U421
	Flp-In-293/ABCB1 cells	Kidney	Homo sapiens (Human)	CVCL_U421
Experiment for Molecule Alteration	ATPase assay
Experiment for Drug Resistance	MTT assay
Mechanism Description	Through calcein assays, we found that epimagnolin A inhibited the ABCB1-mediated export of calcein. This result suggests that epimagnolin A behaved as inhibitor or substrate for ABCB1. In ATPase assays, epimagnolin A stimulated ABCB1-dependent ATPase activity. This result indicates that epimagnolin A was recognised as a substrate by ABCB1, since ABCB1 utilises energy derived from ATP hydrolysis for substrate transport. Furthermore, in MTT assays we found that the cytotoxicity of daunorubicin, doxorubicin, vinblastine, and vincristine was enhanced by epimagnolin A in a manner comparable to verapamil, a typical substrate for ABCB1.

Doxorubicin

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Irregularity in Drug Uptake and Drug Efflux (IDUE)			Click to Show/Hide
Key Molecule: Multidrug resistance protein 1 (ABCB1)				[3]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Differential expression of the molecule in resistant disease
Classification of Disease	Kidney cancer [ICD-11: 2C90]
The Specified Disease	Renal cell carcinoma
The Studied Tissue	Kidney
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 4.11E-46 Fold-change: -1.42E+00 Z-score: -1.91E+01
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	Flp-In-293/Mock cells	Kidney	Homo sapiens (Human)	CVCL_U421
In Vitro Model	Flp-In-293/ABCB1 cells	Kidney	Homo sapiens (Human)	CVCL_U421
Experiment for Molecule Alteration	ATPase assay
Experiment for Drug Resistance	MTT assay
Mechanism Description	Through calcein assays, we found that epimagnolin A inhibited the ABCB1-mediated export of calcein. This result suggests that epimagnolin A behaved as inhibitor or substrate for ABCB1. In ATPase assays, epimagnolin A stimulated ABCB1-dependent ATPase activity. This result indicates that epimagnolin A was recognised as a substrate by ABCB1, since ABCB1 utilises energy derived from ATP hydrolysis for substrate transport. Furthermore, in MTT assays we found that the cytotoxicity of daunorubicin, doxorubicin, vinblastine, and vincristine was enhanced by epimagnolin A in a manner comparable to verapamil, a typical substrate for ABCB1.
Unusual Activation of Pro-survival Pathway (UAPP)			Click to Show/Hide
Key Molecule: CASP8 and FADD-like apoptosis regulator (CFLAR)				[9]
Sensitive Disease	Kidney cancer [ICD-11: 2C90.1]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Differential expression of the molecule in resistant disease
Classification of Disease	Kidney cancer [ICD-11: 2C90]
The Specified Disease	Renal cancer
The Studied Tissue	Kidney
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 8.10E-01 Fold-change: -7.93E-03 Z-score: -2.46E-01
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	Cell apoptosis		Activation	hsa04210
	Cell proliferation		Inhibition	hsa05200
	TRAIL-mediated signaling pathway		Regulation	N.A.
In Vitro Model	Caki cells	Kidney	Homo sapiens (Human)	CVCL_0234
Experiment for Molecule Alteration	Western blot analysis
Experiment for Drug Resistance	Flow cytometry assay
Mechanism Description	C-FLIPL expression was upregulated while miR-708 expression was downregulated in RCC tissues compared to normal tissues. miR-708 functioned as a pro-apoptotic miRNA via specific downregulation of c-FLIPL expression but did not have any effect on the expression of c-FLIPs, which can also increase the drug sensitivity of renal cancer cells.
Key Molecule: Cyclin-G1 (CCNG1)				[10]
Sensitive Disease	Kidney cancer [ICD-11: 2C90.1]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
Cell Pathway Regulation	Cell apoptosis		Activation	hsa04210
Cell Pathway Regulation	miR27b/CCNG1/p53 signaling pathway		Regulation	N.A.
In Vitro Model	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
In Vitro Model	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
Experiment for Molecule Alteration	Western blot analysis
Experiment for Drug Resistance	CellTiter-Glo luminescent cell viability assay
Mechanism Description	miR-27b synergizes with anticancer drugs througth enhancing anticancer drug-induced cell death which due to p53 activation and CYP1B1 suppression.
Drug Inactivation by Structure Modification (DISM)			Click to Show/Hide
Key Molecule: Cytochrome P450 family 1 subfamily B member1 (CYP1B1)				[10]
Sensitive Disease	Kidney cancer [ICD-11: 2C90.1]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
Cell Pathway Regulation	miR27b/CCNG1/p53 signaling pathway		Regulation	N.A.
In Vitro Model	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
In Vitro Model	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
Experiment for Molecule Alteration	Western blot analysis
Experiment for Drug Resistance	CellTiter-Glo luminescent cell viability assay
Mechanism Description	miR-27b synergizes with anticancer drugs througth enhancing anticancer drug-induced cell death which due to p53 activation and CYP1B1 suppression.
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Key Molecule: hsa-mir-708				[9]
Sensitive Disease	Kidney cancer [ICD-11: 2C90.1]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	Cell apoptosis		Activation	hsa04210
	Cell proliferation		Inhibition	hsa05200
	TRAIL-mediated signaling pathway		Regulation	N.A.
In Vitro Model	Caki cells	Kidney	Homo sapiens (Human)	CVCL_0234
Experiment for Molecule Alteration	RT-PCR; RT-PCR
Experiment for Drug Resistance	Flow cytometry assay
Mechanism Description	C-FLIPL expression was upregulated while miR-708 expression was downregulated in RCC tissues compared to normal tissues. miR-708 functioned as a pro-apoptotic miRNA via specific downregulation of c-FLIPL expression but did not have any effect on the expression of c-FLIPs, which can also increase the drug sensitivity of renal cancer cells.
Key Molecule: hsa-mir-27b				[10]
Sensitive Disease	Kidney cancer [ICD-11: 2C90.1]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
Cell Pathway Regulation	miR27b/CCNG1/p53 signaling pathway		Regulation	N.A.
In Vitro Model	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
In Vitro Model	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Nude mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qPCR
Experiment for Drug Resistance	CellTiter-Glo luminescent cell viability assay
Mechanism Description	miR-27b synergizes with anticancer drugs througth enhancing anticancer drug-induced cell death which due to p53 activation and CYP1B1 suppression.
Key Molecule: hsa-miR-1226				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	hsa-mir-1226 is up-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-1234				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is down-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-1253				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is down-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-1265				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is down-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-127-3p				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is up-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-1299				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is down-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-139-3p				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is down-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-140-3p				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is down-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-148a				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is up-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-1538				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is down-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-1539				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is down-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-183				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is up-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-18b				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is up-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-1911				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is up-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-1915				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is down-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-20b				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is up-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-211				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is down-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-215				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is down-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-28-3p				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is up-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-338-5p				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is up-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-342-3p				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is down-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-34c-3p				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is down-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-367				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is up-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-372				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is up-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-380				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is up-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-455-3p				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is up-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-513a-3p				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is down-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-513a-5p				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is down-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-513c				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is down-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-520c-5p				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is up-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-577				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is down-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-606				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is up-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-620				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is up-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-621				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is down-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-625				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is up-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-635				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is up-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-639				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is up-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-769-3p				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is down-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-802				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is down-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-885-3p				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is down-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-891b				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is down-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-892b				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is down-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-920				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is down-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-922				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is down-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-924				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is down-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-933				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is down-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-934				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is down-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-935				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is down-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-124-1				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is up-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-1233-1				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is down-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-526a-1				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is up-regulated in doxorubicin-sensitive cells
Key Molecule: hsa-miR-664a				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HepG2 cells	Liver	Homo sapiens (Human)	CVCL_0027
	Hela cells	Cervix uteri	Homo sapiens (Human)	CVCL_0030
	SNU182 cells	Liver	Homo sapiens (Human)	CVCL_0090
	SNU-739 cells	Liver	Homo sapiens (Human)	CVCL_5088
	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Immunodeficient mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Luciferase assay
Experiment for Drug Resistance	Cell cycle analysis; Apoptosis analysis
Mechanism Description	This gene is down-regulated in doxorubicin-sensitive cells

Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Key Molecule: SET and MYND domain containing 2 (SMYD2)				[4]
Resistant Disease	Kidney cancer [ICD-11: 2C90.1]
Resistant Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Differential expression of the molecule in resistant disease
Classification of Disease	Kidney cancer [ICD-11: 2C90]
The Specified Disease	Kidney cancer
The Studied Tissue	Kidney
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 8.07E-35 Fold-change: 6.59E-01 Z-score: 1.61E+01
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	HEK293T cells	Kidney	Homo sapiens (Human)	CVCL_0063
	HK-2 cells	Kidney	Homo sapiens (Human)	CVCL_0302
In Vivo Model	Balb/c athymic nude mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	Western blotting assay
Experiment for Drug Resistance	MTS assay
Mechanism Description	SMYD2 is a histone methyltransferase.The estimated IC50 values of cisplatin, doxorubicin, or 5-FU (but not docetaxel) for AZ505-treated RCC cells were significantly lower than those for the control cells, indicating that the SMYD2 inhibition enhanced the drug sensitivity in renal cancer cells.
Key Molecule: hsa-mir-451				[15]
Resistant Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Resistant Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	ACHN cells	Pleural effusion	Homo sapiens (Human)	CVCL_1067
	GRC-1 cells	Kidney	Homo sapiens (Human)	N.A.
Experiment for Molecule Alteration	qRT-PCR
Experiment for Drug Resistance	Annexin V-FITC Apoptosis Detection assay; MTT assay
Mechanism Description	microRNA-451 regulates chemoresistance in renal cell carcinoma by targeting ATF-2 gene.
Unusual Activation of Pro-survival Pathway (UAPP)			Click to Show/Hide
Key Molecule: Cyclic AMP-dependent transcription factor ATF-2 (ATF2)				[15]
Resistant Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Resistant Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	ACHN cells	Pleural effusion	Homo sapiens (Human)	CVCL_1067
	GRC-1 cells	Kidney	Homo sapiens (Human)	N.A.
Experiment for Molecule Alteration	Western blot analysis
Experiment for Drug Resistance	Annexin V-FITC Apoptosis Detection assay; MTT assay
Mechanism Description	microRNA-451 regulates chemoresistance in renal cell carcinoma by targeting ATF-2 gene.

Daunorubicin

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Irregularity in Drug Uptake and Drug Efflux (IDUE)			Click to Show/Hide
Key Molecule: Multidrug resistance protein 1 (ABCB1)				[3]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Daunorubicin			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Differential expression of the molecule in resistant disease
Classification of Disease	Kidney cancer [ICD-11: 2C90]
The Specified Disease	Renal cell carcinoma
The Studied Tissue	Kidney
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 4.11E-46 Fold-change: -1.42E+00 Z-score: -1.91E+01
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	Flp-In-293/Mock cells	Kidney	Homo sapiens (Human)	CVCL_U421
	Flp-In-293/ABCB1 cells	Kidney	Homo sapiens (Human)	CVCL_U421
Experiment for Molecule Alteration	ATPase assay
Experiment for Drug Resistance	MTT assay
Mechanism Description	Through calcein assays, we found that epimagnolin A inhibited the ABCB1-mediated export of calcein. This result suggests that epimagnolin A behaved as inhibitor or substrate for ABCB1. In ATPase assays, epimagnolin A stimulated ABCB1-dependent ATPase activity. This result indicates that epimagnolin A was recognised as a substrate by ABCB1, since ABCB1 utilises energy derived from ATP hydrolysis for substrate transport. Furthermore, in MTT assays we found that the cytotoxicity of daunorubicin, doxorubicin, vinblastine, and vincristine was enhanced by epimagnolin A in a manner comparable to verapamil, a typical substrate for ABCB1.

Docetaxel

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Key Molecule: SET and MYND domain containing 2 (SMYD2)				[4]
Resistant Disease	Kidney cancer [ICD-11: 2C90.1]
Resistant Drug	Docetaxel			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Differential expression of the molecule in resistant disease
Classification of Disease	Kidney cancer [ICD-11: 2C90]
The Specified Disease	Kidney cancer
The Studied Tissue	Kidney
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 8.07E-35 Fold-change: 6.59E-01 Z-score: 1.61E+01
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	HEK293T cells	Kidney	Homo sapiens (Human)	CVCL_0063
	HK-2 cells	Kidney	Homo sapiens (Human)	CVCL_0302
In Vivo Model	Balb/c athymic nude mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	Western blotting assay
Experiment for Drug Resistance	MTS assay
Mechanism Description	SMYD2 is a histone methyltransferase.The estimated IC50 values of cisplatin, doxorubicin, or 5-FU (but not docetaxel) for AZ505-treated RCC cells were significantly lower than those for the control cells, indicating that the SMYD2 inhibition enhanced the drug sensitivity in renal cancer cells.

Cisplatin

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Key Molecule: SET and MYND domain containing 2 (SMYD2)				[4]
Resistant Disease	Kidney cancer [ICD-11: 2C90.1]
Resistant Drug	Cisplatin			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Differential expression of the molecule in resistant disease
Classification of Disease	Kidney cancer [ICD-11: 2C90]
The Specified Disease	Kidney cancer
The Studied Tissue	Kidney
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 8.07E-35 Fold-change: 6.59E-01 Z-score: 1.61E+01
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	HEK293T cells	Kidney	Homo sapiens (Human)	CVCL_0063
	HK-2 cells	Kidney	Homo sapiens (Human)	CVCL_0302
In Vivo Model	Balb/c athymic nude mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	Western blotting assay
Experiment for Drug Resistance	MTS assay
Mechanism Description	SMYD2 is a histone methyltransferase.The estimated IC50 values of cisplatin, doxorubicin, or 5-FU (but not docetaxel) for AZ505-treated RCC cells were significantly lower than those for the control cells, indicating that the SMYD2 inhibition enhanced the drug sensitivity in renal cancer cells.

Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Key Molecule: hsa-mir-148a				[14]
Sensitive Disease	Kidney cancer [ICD-11: 2C90.1]
Sensitive Drug	Cisplatin			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	Caspase signaling pathway		Activation	hsa04210
In Vitro Model	Caki cells	Kidney	Homo sapiens (Human)	CVCL_0234
Experiment for Molecule Alteration	RT-PCR
Experiment for Drug Resistance	Flow cytometry assay; PI/Annexin staining assay
Mechanism Description	miR148a increases the sensitivity to cisplatin by targeting Rab14 in renal cancer cells, transfection with the miR148a mimics resulted in the activation of caspase pathway.
Key Molecule: hsa-mir-27b				[10]
Sensitive Disease	Kidney cancer [ICD-11: 2C90.1]
Sensitive Drug	Cisplatin			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
Cell Pathway Regulation	miR27b/CCNG1/p53 signaling pathway		Regulation	N.A.
In Vitro Model	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Nude mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qPCR
Experiment for Drug Resistance	CellTiter-Glo luminescent cell viability assay
Mechanism Description	miR-27b synergizes with anticancer drugs througth enhancing anticancer drug-induced cell death which due to p53 activation and CYP1B1 suppression.
Unusual Activation of Pro-survival Pathway (UAPP)			Click to Show/Hide
Key Molecule: Ras-related protein Rab-14 (RAB14)				[14]
Sensitive Disease	Kidney cancer [ICD-11: 2C90.1]
Sensitive Drug	Cisplatin			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	Caspase signaling pathway		Activation	hsa04210
In Vitro Model	Caki cells	Kidney	Homo sapiens (Human)	CVCL_0234
Experiment for Molecule Alteration	RT-PCR; Western blot analysis
Experiment for Drug Resistance	Flow cytometry assay; PI/Annexin staining assay
Mechanism Description	miR148a increases the sensitivity to cisplatin by targeting Rab14 in renal cancer cells, transfection with the miR148a mimics resulted in the activation of caspase pathway.
Key Molecule: Cyclin-G1 (CCNG1)				[10]
Sensitive Disease	Kidney cancer [ICD-11: 2C90.1]
Sensitive Drug	Cisplatin			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
Cell Pathway Regulation	Cell apoptosis		Activation	hsa04210
	miR27b/CCNG1/p53 signaling pathway		Regulation	N.A.
In Vitro Model	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
Experiment for Molecule Alteration	Western blot analysis
Experiment for Drug Resistance	CellTiter-Glo luminescent cell viability assay
Mechanism Description	miR-27b synergizes with anticancer drugs througth enhancing anticancer drug-induced cell death which due to p53 activation and CYP1B1 suppression.

Sorafenib

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Key Molecule: LncRNA sorafenib resistance in renal cell carcinoma associated (LNCSRLR)				[7]
Resistant Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Resistant Drug	Sorafenib			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Differential expression of the molecule in resistant disease
Classification of Disease	Kidney cancer [ICD-11: 2C90]
The Specified Disease	Kidney clear cell carcinoma
The Studied Tissue	Kidney
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 1.90E-47 Fold-change: 2.36E+00 Z-score: 1.57E+01
Experimental Note	Identified from the Human Clinical Data
Cell Pathway Regulation	Sorafenib tolerance		Activation	hsa00983
In Vitro Model	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
	A498 cells	Kidney	Homo sapiens (Human)	CVCL_1056
	Caki-2 cells	Kidney	Homo sapiens (Human)	CVCL_0235
	OSRC-2 cells	Kidney	Homo sapiens (Human)	CVCL_1626
Experiment for Molecule Alteration	Microarray assay
Experiment for Drug Resistance	CCK8 assay
Mechanism Description	Long noncoding RNA-SRLR elicits intrinsic sorafenib resistance via evoking IL-6/STAT3 axis in renal cell carcinoma. LncRNA-SRLR directly binds to NF-kB and promotes IL-6 transcription, leading to the activation of STAT3 and the development of sorafenib tolerance.
Key Molecule: Interleukin-6 (IL6)				[7]
Resistant Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Resistant Drug	Sorafenib			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Differential expression of the molecule in resistant disease
Classification of Disease	Kidney cancer [ICD-11: 2C90]
The Specified Disease	Renal cancer
The Studied Tissue	Kidney
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 2.23E-04 Fold-change: 2.17E-01 Z-score: 4.95E+00
Experimental Note	Identified from the Human Clinical Data
Cell Pathway Regulation	Cell cytotoxicity		Activation	hsa04650
	Tumorigenesis		Inhibition	hsa05200
In Vitro Model	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
	A498 cells	Kidney	Homo sapiens (Human)	CVCL_1056
	Caki-2 cells	Kidney	Homo sapiens (Human)	CVCL_0235
	OSRC-2 cells	Kidney	Homo sapiens (Human)	CVCL_1626
Experiment for Molecule Alteration	qRT-PCR
Experiment for Drug Resistance	CCK8 assay
Mechanism Description	Long noncoding RNA-SRLR elicits intrinsic sorafenib resistance via evoking IL-6/STAT3 axis in renal cell carcinoma. LncRNA-SRLR directly binds to NF-kB and promotes IL-6 transcription, leading to the activation of STAT3 and the development of sorafenib tolerance.
Unusual Activation of Pro-survival Pathway (UAPP)			Click to Show/Hide
Key Molecule: Signal transducer activator transcription 3 (STAT3)				[7]
Resistant Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Resistant Drug	Sorafenib			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Differential expression of the molecule in resistant disease
Classification of Disease	Kidney cancer [ICD-11: 2C90]
The Specified Disease	Renal cancer
The Studied Tissue	Kidney
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 6.66E-01 Fold-change: 1.15E-02 Z-score: 4.44E-01
Experimental Note	Identified from the Human Clinical Data
Cell Pathway Regulation	Sorafenib tolerance		Activation	hsa00983
In Vitro Model	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
	A498 cells	Kidney	Homo sapiens (Human)	CVCL_1056
	Caki-2 cells	Kidney	Homo sapiens (Human)	CVCL_0235
	OSRC-2 cells	Kidney	Homo sapiens (Human)	CVCL_1626
Experiment for Molecule Alteration	Western blot analysis
Experiment for Drug Resistance	CCK8 assay
Mechanism Description	Long noncoding RNA-SRLR elicits intrinsic sorafenib resistance via evoking IL-6/STAT3 axis in renal cell carcinoma. LncRNA-SRLR directly binds to NF-kB and promotes IL-6 transcription, leading to the activation of STAT3 and the development of sorafenib tolerance.

Drug Sensitive Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Key Molecule: hsa-miR-200c				[19]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Sorafenib			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HEK293 cells	Kidney	Homo sapiens (Human)	CVCL_0045
	SN12C cells	Kidney	Homo sapiens (Human)	CVCL_1705
	ACHN cells	Pleural effusion	Homo sapiens (Human)	CVCL_1067
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
	Caki-1 cells	Kidney	Homo sapiens (Human)	CVCL_0234
Experiment for Molecule Alteration	qPCR
Experiment for Drug Resistance	CCK8 assay
Mechanism Description	In the present study, we demonstrated the regulatory relationship between miR-200c and HO-1. We provided evidences to elucidate that miR-200c could sensitize ccRCC cells to sorafenib or imatinib to inhibit cell proliferation, at least partly by targeting HO-1. Moreover, the correlation between miR-200c and HO-1 expression level and drug resistance in ccRCC was also determined. Combined application with chemotherapeutic drugs, miR-200c, a HO-1 inhibitor, may enhance the efficiency of therapy by promoting both apoptosis and autophagy.
Key Molecule: hsa-miR-30a				[16]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Sorafenib			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	Autophagy		Regulation	N.A.
In Vitro Model	786-0 cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vitro Model	A498 cells	Kidney	Homo sapiens (Human)	CVCL_1056
Experiment for Molecule Alteration	RT-PCR
Experiment for Drug Resistance	MTT assay
Mechanism Description	Knockdown of miR-30a by introducing antagomiR-30a increased Beclin-1 expression, and inhibited sorafenib-induced cytotoxicity against RCC cells. Autophagy inhibitors, including chloroquine, 3-methyaldenine or Bafliomycin A1, enhanced sorafenib activity, causing substantial cell apoptosis. Meanwhile, knockdown of Beclin-1 or ATG-5 by targeted siRNAs also increased sorafenib-induced cytotoxicity in above RCC cells. These findings indicate that dysregulation of miR-30a in RCC may interfere with the effectiveness of sorafenib-mediated apoptosis by an autophagy-dependent pathway, thus representing a novel potential therapeutic target for RCC.

Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Drug Inactivation by Structure Modification (DISM)			Click to Show/Hide
Key Molecule: Cytochrome P450 family 1 subfamily B member1 (CYP1B1)				[10]
Sensitive Disease	Kidney cancer [ICD-11: 2C90.1]
Sensitive Drug	Sorafenib			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
Cell Pathway Regulation	miR27b/CCNG1/p53 signaling pathway		Regulation	N.A.
In Vitro Model	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
Experiment for Molecule Alteration	Western blot analysis
Experiment for Drug Resistance	CellTiter-Glo luminescent cell viability assay
Mechanism Description	miR-27b synergizes with anticancer drugs througth enhancing anticancer drug-induced cell death which due to p53 activation and CYP1B1 suppression.
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Key Molecule: hsa-mir-27b				[10]
Sensitive Disease	Kidney cancer [ICD-11: 2C90.1]
Sensitive Drug	Sorafenib			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
Cell Pathway Regulation	miR27b/CCNG1/p53 signaling pathway		Regulation	N.A.
In Vitro Model	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Nude mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qPCR
Experiment for Drug Resistance	CellTiter-Glo luminescent cell viability assay
Mechanism Description	miR-27b synergizes with anticancer drugs througth enhancing anticancer drug-induced cell death which due to p53 activation and CYP1B1 suppression.
Unusual Activation of Pro-survival Pathway (UAPP)			Click to Show/Hide
Key Molecule: Cyclin-G1 (CCNG1)				[10]
Sensitive Disease	Kidney cancer [ICD-11: 2C90.1]
Sensitive Drug	Sorafenib			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
Cell Pathway Regulation	Cell apoptosis		Activation	hsa04210
	miR27b/CCNG1/p53 signaling pathway		Regulation	N.A.
In Vitro Model	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
Experiment for Molecule Alteration	Western blot analysis
Experiment for Drug Resistance	CellTiter-Glo luminescent cell viability assay
Mechanism Description	miR-27b synergizes with anticancer drugs througth enhancing anticancer drug-induced cell death which due to p53 activation and CYP1B1 suppression.

Topotecan

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Unusual Activation of Pro-survival Pathway (UAPP)			Click to Show/Hide
Key Molecule: Programmed cell death protein 4 (PDCD4)				[8]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Topotecan			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Differential expression of the molecule in resistant disease
Classification of Disease	Kidney cancer [ICD-11: 2C90]
The Specified Disease	Renal cancer
The Studied Tissue	Kidney
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 5.92E-07 Fold-change: 2.01E-01 Z-score: 8.08E+00
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	Cell apoptosis		Activation	hsa04210
	Cell colony		Inhibition	hsa05200
	Cell viability		Inhibition	hsa05200
In Vitro Model	A498 cells	Kidney	Homo sapiens (Human)	CVCL_1056
Experiment for Molecule Alteration	Western blot analysis
Experiment for Drug Resistance	XTT assay
Mechanism Description	Inhibition of miR-21 rescues PDCD4 and PTEN protein levels and improves chemosensitivity and therapeutic response.

Gefitinib

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Drug Inactivation by Structure Modification (DISM)			Click to Show/Hide
Key Molecule: Cytochrome P450 family 1 subfamily B member1 (CYP1B1)				[10]
Sensitive Disease	Kidney cancer [ICD-11: 2C90.1]
Sensitive Drug	Gefitinib			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Differential expression of the molecule in resistant disease
Classification of Disease	Kidney cancer [ICD-11: 2C90]
The Specified Disease	Renal cancer
The Studied Tissue	Kidney
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 9.73E-03 Fold-change: -1.49E-01 Z-score: -3.05E+00
Experimental Note	Identified from the Human Clinical Data
Cell Pathway Regulation	miR27b/CCNG1/p53 signaling pathway		Regulation	N.A.
In Vitro Model	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
Experiment for Molecule Alteration	Western blot analysis
Experiment for Drug Resistance	CellTiter-Glo luminescent cell viability assay
Mechanism Description	miR-27b synergizes with anticancer drugs througth enhancing anticancer drug-induced cell death which due to p53 activation and CYP1B1 suppression.
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Key Molecule: hsa-mir-27b				[10]
Sensitive Disease	Kidney cancer [ICD-11: 2C90.1]
Sensitive Drug	Gefitinib			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
Cell Pathway Regulation	miR27b/CCNG1/p53 signaling pathway		Regulation	N.A.
In Vitro Model	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Nude mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qPCR
Experiment for Drug Resistance	CellTiter-Glo luminescent cell viability assay
Mechanism Description	miR-27b synergizes with anticancer drugs througth enhancing anticancer drug-induced cell death which due to p53 activation and CYP1B1 suppression.
Unusual Activation of Pro-survival Pathway (UAPP)			Click to Show/Hide
Key Molecule: Cyclin-G1 (CCNG1)				[10]
Sensitive Disease	Kidney cancer [ICD-11: 2C90.1]
Sensitive Drug	Gefitinib			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
Cell Pathway Regulation	Cell apoptosis		Activation	hsa04210
	miR27b/CCNG1/p53 signaling pathway		Regulation	N.A.
In Vitro Model	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
Experiment for Molecule Alteration	Western blot analysis
Experiment for Drug Resistance	CellTiter-Glo luminescent cell viability assay
Mechanism Description	miR-27b synergizes with anticancer drugs througth enhancing anticancer drug-induced cell death which due to p53 activation and CYP1B1 suppression.

Vincristine

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Irregularity in Drug Uptake and Drug Efflux (IDUE)			Click to Show/Hide
Key Molecule: Multidrug resistance protein 1 (ABCB1)				[3]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Vincristine			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Differential expression of the molecule in resistant disease
Classification of Disease	Kidney cancer [ICD-11: 2C90]
The Specified Disease	Renal cancer
The Studied Tissue	Kidney
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 2.04E-02 Fold-change: -1.96E-01 Z-score: -2.71E+00
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	Flp-In-293/Mock cells	Kidney	Homo sapiens (Human)	CVCL_U421
	Flp-In-293/ABCB1 cells	Kidney	Homo sapiens (Human)	CVCL_U421
Experiment for Molecule Alteration	ATPase assay
Experiment for Drug Resistance	MTT assay
Mechanism Description	Through calcein assays, we found that epimagnolin A inhibited the ABCB1-mediated export of calcein. This result suggests that epimagnolin A behaved as inhibitor or substrate for ABCB1. In ATPase assays, epimagnolin A stimulated ABCB1-dependent ATPase activity. This result indicates that epimagnolin A was recognised as a substrate by ABCB1, since ABCB1 utilises energy derived from ATP hydrolysis for substrate transport. Furthermore, in MTT assays we found that the cytotoxicity of daunorubicin, doxorubicin, vinblastine, and vincristine was enhanced by epimagnolin A in a manner comparable to verapamil, a typical substrate for ABCB1.

Cabozantinib

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Regulation by the Disease Microenvironment (RTDM)			Click to Show/Hide
Key Molecule: Pro-angiogenic factors				[13]
Resistant Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Resistant Drug	Cabozantinib			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	VeroE6/TMPRSS2 cells	Kidney	Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus)	CVCL_YQ49
	HUVEC cells	Endothelium	Homo sapiens (Human)	N.A.
Experiment for Molecule Alteration	Secreted protein measurements assay
Experiment for Drug Resistance	Flow cytometry
Mechanism Description	We show that circulating immune cells from patients with ccRCC induce cabozantinib resistance via increased secretion of a set of pro-angiogenic factors.

Epirubicin

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Drug Inactivation by Structure Modification (DISM)			Click to Show/Hide
Key Molecule: Cytochrome P450 family 1 subfamily B member1 (CYP1B1)				[10]
Sensitive Disease	Kidney cancer [ICD-11: 2C90.1]
Sensitive Drug	Epirubicin			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
Cell Pathway Regulation	miR27b/CCNG1/p53 signaling pathway		Regulation	N.A.
In Vitro Model	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
Experiment for Molecule Alteration	Western blot analysis
Experiment for Drug Resistance	CellTiter-Glo luminescent cell viability assay
Mechanism Description	miR-27b synergizes with anticancer drugs througth enhancing anticancer drug-induced cell death which due to p53 activation and CYP1B1 suppression.
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Key Molecule: hsa-mir-27b				[10]
Sensitive Disease	Kidney cancer [ICD-11: 2C90.1]
Sensitive Drug	Epirubicin			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
Cell Pathway Regulation	miR27b/CCNG1/p53 signaling pathway		Regulation	N.A.
In Vitro Model	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Nude mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qPCR
Experiment for Drug Resistance	CellTiter-Glo luminescent cell viability assay
Mechanism Description	miR-27b synergizes with anticancer drugs througth enhancing anticancer drug-induced cell death which due to p53 activation and CYP1B1 suppression.
Unusual Activation of Pro-survival Pathway (UAPP)			Click to Show/Hide
Key Molecule: Cyclin-G1 (CCNG1)				[10]
Sensitive Disease	Kidney cancer [ICD-11: 2C90.1]
Sensitive Drug	Epirubicin			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
Cell Pathway Regulation	Cell apoptosis		Activation	hsa04210
	miR27b/CCNG1/p53 signaling pathway		Regulation	N.A.
In Vitro Model	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
Experiment for Molecule Alteration	Western blot analysis
Experiment for Drug Resistance	CellTiter-Glo luminescent cell viability assay
Mechanism Description	miR-27b synergizes with anticancer drugs througth enhancing anticancer drug-induced cell death which due to p53 activation and CYP1B1 suppression.

Etoposide

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Drug Inactivation by Structure Modification (DISM)			Click to Show/Hide
Key Molecule: Cytochrome P450 family 1 subfamily B member1 (CYP1B1)				[10]
Sensitive Disease	Kidney cancer [ICD-11: 2C90.1]
Sensitive Drug	Etoposide			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
Cell Pathway Regulation	miR27b/CCNG1/p53 signaling pathway		Regulation	N.A.
In Vitro Model	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
Experiment for Molecule Alteration	Western blot analysis
Experiment for Drug Resistance	CellTiter-Glo luminescent cell viability assay
Mechanism Description	miR-27b synergizes with anticancer drugs througth enhancing anticancer drug-induced cell death which due to p53 activation and CYP1B1 suppression.
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Key Molecule: hsa-mir-27b				[10]
Sensitive Disease	Kidney cancer [ICD-11: 2C90.1]
Sensitive Drug	Etoposide			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
Cell Pathway Regulation	miR27b/CCNG1/p53 signaling pathway		Regulation	N.A.
In Vitro Model	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
In Vivo Model	Nude mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	qPCR
Experiment for Drug Resistance	CellTiter-Glo luminescent cell viability assay
Mechanism Description	miR-27b synergizes with anticancer drugs througth enhancing anticancer drug-induced cell death which due to p53 activation and CYP1B1 suppression.
Unusual Activation of Pro-survival Pathway (UAPP)			Click to Show/Hide
Key Molecule: Cyclin-G1 (CCNG1)				[10]
Sensitive Disease	Kidney cancer [ICD-11: 2C90.1]
Sensitive Drug	Etoposide			Drug Info
Molecule Alteration	Expression		Down-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
Cell Pathway Regulation	Cell apoptosis		Activation	hsa04210
	miR27b/CCNG1/p53 signaling pathway		Regulation	N.A.
In Vitro Model	769-P cells	Kidney	Homo sapiens (Human)	CVCL_1050
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
Experiment for Molecule Alteration	Western blot analysis
Experiment for Drug Resistance	CellTiter-Glo luminescent cell viability assay
Mechanism Description	miR-27b synergizes with anticancer drugs througth enhancing anticancer drug-induced cell death which due to p53 activation and CYP1B1 suppression.

Everolimus

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Regulation by the Disease Microenvironment (RTDM)			Click to Show/Hide
Key Molecule: hsa-mir-92a				[17]
Resistant Disease	Kidney cancer [ICD-11: 2C90.1]
Resistant Drug	Everolimus			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Caki-1 cells	Kidney	Homo sapiens (Human)	CVCL_0234
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
	ACHN cells	Pleural effusion	Homo sapiens (Human)	CVCL_1067
	A498 cells	Kidney	Homo sapiens (Human)	CVCL_1056
Experiment for Molecule Alteration	qRT-PCR
Experiment for Drug Resistance	CCK8 assay
Mechanism Description	NC886 also promotes renal cancer cell drug-resistance to Sunitinib or Everolimus by promoting EMT through Rock2 phosphorylation-mediated nuclear translocation of beta-catenin.

Imatinib

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Aberration of the Drug's Therapeutic Target (ADTT)			Click to Show/Hide
Key Molecule: Mast/stem cell growth factor receptor Kit (KIT)				[18]
Resistant Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Resistant Drug	Imatinib			Drug Info
Molecule Alteration	Dimerisation		Up-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	HEK 293 cells	Kidney	Homo sapiens (Human)	CVCL_0045
Experiment for Molecule Alteration	Western blot analysis
Experiment for Drug Resistance	Flow cytometry
Mechanism Description	These results demonstrated that the c-kit mutation drove auto-dimerisation, and promoted receptor phosphorylation, and ligand-independent receptor signalling pathway. Therefore, dimerisation is the common step in both the activation processes of KIT prior to phosphorylation and therefore, blocking receptor dimerisation may be more effective than blocking the phosphorylated receptor.

Drug Sensitive Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Key Molecule: hsa-miR-200c				[19]
Sensitive Disease	Renal cell carcinoma [ICD-11: 2C90.0]
Sensitive Drug	Imatinib			Drug Info
Molecule Alteration	Expression		Up-regulation	Molecule Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HEK293 cells	Kidney	Homo sapiens (Human)	CVCL_0045
	SN12C cells	Kidney	Homo sapiens (Human)	CVCL_1705
	ACHN cells	Pleural effusion	Homo sapiens (Human)	CVCL_1067
	786-O cells	Kidney	Homo sapiens (Human)	CVCL_1051
	Caki-1 cells	Kidney	Homo sapiens (Human)	CVCL_0234
Experiment for Molecule Alteration	qPCR
Experiment for Drug Resistance	CCK8 assay
Mechanism Description	In the present study, we demonstrated the regulatory relationship between miR-200c and HO-1. We provided evidences to elucidate that miR-200c could sensitize ccRCC cells to sorafenib or imatinib to inhibit cell proliferation, at least partly by targeting HO-1. Moreover, the correlation between miR-200c and HO-1 expression level and drug resistance in ccRCC was also determined. Combined application with chemotherapeutic drugs, miR-200c, a HO-1 inhibitor, may enhance the efficiency of therapy by promoting both apoptosis and autophagy.

References

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Ref 2	Targeting miR-21 decreases expression of multi-drug resistant genes and promotes chemosensitivity of renal carcinoma. Tumour Biol. 2017 Jul;39(7):1010428317707372. doi: 10.1177/1010428317707372.
Ref 3	Epimagnolin A, a tetrahydrofurofuranoid lignan from Magnolia fargesii, reverses ABCB1-mediated drug resistance .Phytomedicine. 2018 Dec 1;51:112-119. doi: 10.1016/j.phymed.2018.06.030. Epub 2018 Jun 20. 10.1016/j.phymed.2018.06.030
Ref 4	Inhibition of SMYD2 suppresses tumor progression by down-regulating microRNA-125b and attenuates multi-drug resistance in renal cell carcinoma .Theranostics. 2019 Oct 22;9(26):8377-8391. doi: 10.7150/thno.37628. eCollection 2019. 10.7150/thno.37628
Ref 5	miR-381, a novel intrinsic WEE1 inhibitor, sensitizes renal cancer cells to 5-FU by up-regulation of Cdc2 activities in 786-O. J Chemother. 2013 Aug;25(4):229-38. doi: 10.1179/1973947813Y.0000000092. Epub 2013 May 7.
Ref 6	Exosome-Transmitted lncARSR Promotes Sunitinib Resistance in Renal Cancer by Acting as a Competing Endogenous RNA. Cancer Cell. 2016 May 9;29(5):653-668. doi: 10.1016/j.ccell.2016.03.004. Epub 2016 Apr 21.
Ref 7	Long noncoding RNA-SRLR elicits intrinsic sorafenib resistance via evoking IL-6/STAT3 axis in renal cell carcinoma. Oncogene. 2017 Apr 6;36(14):1965-1977. doi: 10.1038/onc.2016.356. Epub 2016 Nov 14.
Ref 8	Small Molecule Inhibition of MicroRNA miR-21 Rescues Chemosensitivity of Renal-Cell Carcinoma to Topotecan. J Med Chem. 2018 Jul 26;61(14):5900-5909. doi: 10.1021/acs.jmedchem.7b01891. Epub 2018 Jul 11.
Ref 9	Inhibition of c-FLIPL expression by miRNA-708 increases the sensitivity of renal cancer cells to anti-cancer drugs. Oncotarget. 2016 May 31;7(22):31832-46. doi: 10.18632/oncotarget.7149.
Ref 10	miR-27b synergizes with anticancer drugs via p53 activation and CYP1B1 suppression. Cell Res. 2015 Apr;25(4):477-95. doi: 10.1038/cr.2015.23. Epub 2015 Feb 20.
Ref 11	Mir-144-3p Promotes Cell Proliferation, Metastasis, Sunitinib Resistance in Clear Cell Renal Cell Carcinoma by Downregulating ARID1A. Cell Physiol Biochem. 2017;43(6):2420-2433. doi: 10.1159/000484395. Epub 2017 Oct 27.
Ref 12	Combining the Tyrosine Kinase Inhibitor Cabozantinib and the mTORC1/2 Inhibitor Sapanisertib Blocks ERK Pathway Activity and Suppresses Tumor Growth in Renal Cell Carcinoma. Cancer Res. 2023 Dec 15;83(24):4161-4178.
Ref 13	Immune cell mediated cabozantinib resistance for patients with renal cell carcinoma .Integr Biol (Camb). 2021 Dec 30;13(11):259-268. doi: 10.1093/intbio/zyab018. 10.1093/intbio/zyab018
Ref 14	miR-148a increases the sensitivity to cisplatin by targeting Rab14 in renal cancer cells. Int J Oncol. 2017 Mar;50(3):984-992. doi: 10.3892/ijo.2017.3851. Epub 2017 Jan 17.
Ref 15	MicroRNA-451 regulates chemoresistance in renal cell carcinoma by targeting ATF-2 gene. Exp Biol Med (Maywood). 2017 Jun;242(12):1299-1305. doi: 10.1177/1535370217701625. Epub 2017 Apr 21.
Ref 16	The Selective PI3K Inhibitor XL147 (SAR245408) Inhibits Tumor Growth and Survival and Potentiates the Activity of Chemotherapeutic Agents in Preclinical Tumor ModelsMol Cancer Ther. 2015 Apr;14(4):931-40. doi: 10.1158/1535-7163.MCT-14-0833. Epub 2015 Jan 30.
Ref 17	Nc886 promotes renal cancer cell drug-resistance by enhancing EMT through Rock2 phosphorylation-mediated Beta-catenin nuclear translocation .Cell Cycle. 2022 Feb;21(4):340-351. doi: 10.1080/15384101.2021.2020431. Epub 2022 Jan 2. 10.1080/15384101.2021.2020431
Ref 18	Management of metastatic gastrointestinal stromal tumour in the Glivec era: a practical case-based approach .Intern Med J. 2006 Jun;36(6):367-77. doi: 10.1111/j.1445-5994.2006.01077.x. 10.1111/j.1445-5994.2006.01077.x
Ref 19	Characterization of the activity of the PI3K/mTOR inhibitor XL765 (SAR245409) in tumor models with diverse genetic alterations affecting the PI3K pathwayMol Cancer Ther. 2014 May;13(5):1078-91. doi: 10.1158/1535-7163.MCT-13-0709. Epub 2014 Mar 14.
Ref 20	miR-130b Promotes Sunitinib Resistance through Regulation of PTEN in Renal Cell Carcinoma. Oncology. 2019;97(3):164-172. doi: 10.1159/000500605. Epub 2019 Jun 13.
Ref 21	LncRNA-SARCC suppresses renal cell carcinoma (RCC) progression via altering the androgen receptor(AR)/miRNA-143-3p signals. Cell Death Differ. 2017 Sep;24(9):1502-1517. doi: 10.1038/cdd.2017.74. Epub 2017 Jun 23.
Ref 22	VS-5584, a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancerMol Cancer Ther. 2013 Feb;12(2):151-61. doi: 10.1158/1535-7163.MCT-12-0466. Epub 2012 Dec 27.

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Correspondence

Prof. Feng ZHU (zhufeng@zju.edu.cn)