Molecule Information

General Information of the Molecule (ID: Mol02129)

• Name: Pro-angiogenic factors ,Homo sapiens
• Synonyms: Pro-angiogenic factors gene
• Molecule Type: Protein
• Gene Name: Pro-angiogenic factors gene

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  RTDM: Regulation by the Disease Microenvironment

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Cabozantinib

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Regulation by the Disease Microenvironment (RTDM)

Disease Class: Renal cell carcinoma [1]

• Resistant Disease: Renal cell carcinoma [ICD-11: 2C90.0]
• Resistant Drug: Cabozantinib
• Molecule Alteration: Expression; Up-regulation
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: VeroE6/TMPRSS2 cells; Kidney; Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus); CVCL_YQ49
• In Vitro Model: HUVEC cells; Endothelium; Homo sapiens (Human); N.A.
• Experiment for Molecule Alteration: Secreted protein measurements assay
• Experiment for Drug Resistance: Flow cytometry
• Mechanism Description: We show that circulating immune cells from patients with ccRCC induce cabozantinib resistance via increased secretion of a set of pro-angiogenic factors.

References

• Ref 1: Immune cell mediated cabozantinib resistance for patients with renal cell carcinoma .Integr Biol (Camb). 2021 Dec 30;13(11):259-268. doi: 10.1093/intbio/zyab018. 10.1093/intbio/zyab018