Disease Information

General Information of the Disease (ID: DIS00142)
Name
Surgical wound infection
ICD
ICD-11: NE81
Resistance Map
Type(s) of Resistant Mechanism of This Disease
  ADTT: Aberration of the Drug's Therapeutic Target
  IDUE: Irregularity in Drug Uptake and Drug Efflux
Drug Resistance Data Categorized by Drug
Approved Drug(s)
11 drug(s) in total
Click to Show/Hide the Full List of Drugs
Chloramphenicol
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Irregularity in Drug Uptake and Drug Efflux (IDUE) Click to Show/Hide
Key Molecule: Lincomycin resistance efflux pump (LMRS) [1]
Resistant Disease Staphylococcus aureus infection [ICD-11: 1B54.0]
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Resistant Drug Chloramphenicol
 Drug Info 
Experimental Note Identified from the Human Clinical Data
In Vitro Model Escherichia coli kAM32 562
Staphylococcus aureus OM505 1280
Experiment for
Molecule Alteration		 Whole genome sequence assay; Allelic frequency measurement assay
Experiment for
Drug Resistance		 Broth microdilution method assay
Mechanism Description LmrS is a multidrug efflux pump of the major facilitator superfamily from staphylococcus aureus.
Clarithromycin
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Aberration of the Drug's Therapeutic Target (ADTT) Click to Show/Hide
Key Molecule: Erythromycin resistance protein (ERM38) [2]
Resistant Disease Mycobacterium smegmatis infection [ICD-11: 1B2Z.3]
Molecule Alteration Expression
Inherence
 Molecule Info 
Resistant Drug Clarithromycin
 Drug Info 
Experimental Note Identified from the Human Clinical Data
In Vitro Model Mycobacterium smegmatis mc2155 246196
Mycobacterium smegmatis mc2155/pMIP12 246196
Mycobacterium smegmatis mc2155/pOMV20 246196
Mycobacterium smegmatis mc2155/pOMV30 246196
Experiment for
Molecule Alteration		 MALDI mass spectrometry assay
Experiment for
Drug Resistance		 MIC assay
Mechanism Description Erm (38) is a specific dimethyltransferase. The strain obtained drug resistance by adding two methyl groups to A2058 in Mycobacterium 23SrRNA.
Key Molecule: Erythromycin resistance protein (ERM38) [2]
Resistant Disease Mycobacterium smegmatis infection [ICD-11: 1B2Z.3]
Molecule Alteration Expression
Inherence
 Molecule Info 
Resistant Drug Clarithromycin
 Drug Info 
Experimental Note Identified from the Human Clinical Data
In Vitro Model Mycobacterium smegmatis mc2155 246196
Mycobacterium smegmatis mc2155/pMIP12 246196
Mycobacterium smegmatis mc2155/pOMV20 246196
Mycobacterium smegmatis mc2155/pOMV30 246196
Experiment for
Molecule Alteration		 MALDI mass spectrometry assay
Experiment for
Drug Resistance		 MIC assay
Mechanism Description Erm (38) is a specific dimethyltransferase. The strain obtained drug resistance by adding two methyl groups to A2058 in Mycobacterium 23SrRNA.
Clindamycin
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Aberration of the Drug's Therapeutic Target (ADTT) Click to Show/Hide
Key Molecule: Erythromycin resistance protein (ERM38) [2]
Resistant Disease Mycobacterium smegmatis infection [ICD-11: 1B2Z.3]
Molecule Alteration Expression
Inherence
 Molecule Info 
Resistant Drug Clindamycin
 Drug Info 
Experimental Note Identified from the Human Clinical Data
In Vitro Model Mycobacterium smegmatis mc2155 246196
Mycobacterium smegmatis mc2155/pMIP12 246196
Mycobacterium smegmatis mc2155/pOMV20 246196
Mycobacterium smegmatis mc2155/pOMV30 246196
Experiment for
Molecule Alteration		 MALDI mass spectrometry assay
Experiment for
Drug Resistance		 MIC assay
Mechanism Description Erm (38) is a specific dimethyltransferase. The strain obtained drug resistance by adding two methyl groups to A2058 in Mycobacterium 23SrRNA.
Key Molecule: Erythromycin resistance protein (ERM38) [2]
Resistant Disease Mycobacterium smegmatis infection [ICD-11: 1B2Z.3]
Molecule Alteration Expression
Inherence
 Molecule Info 
Resistant Drug Clindamycin
 Drug Info 
Experimental Note Identified from the Human Clinical Data
In Vitro Model Mycobacterium smegmatis mc2155 246196
Mycobacterium smegmatis mc2155/pMIP12 246196
Mycobacterium smegmatis mc2155/pOMV20 246196
Mycobacterium smegmatis mc2155/pOMV30 246196
Experiment for
Molecule Alteration		 MALDI mass spectrometry assay
Experiment for
Drug Resistance		 MIC assay
Mechanism Description Erm (38) is a specific dimethyltransferase. The strain obtained drug resistance by adding two methyl groups to A2058 in Mycobacterium 23SrRNA.
Erythromycin
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Aberration of the Drug's Therapeutic Target (ADTT) Click to Show/Hide
Key Molecule: Erythromycin resistance protein (ERM38) [2]
Resistant Disease Mycobacterium smegmatis infection [ICD-11: 1B2Z.3]
Molecule Alteration Expression
Inherence
 Molecule Info 
Resistant Drug Erythromycin
 Drug Info 
Experimental Note Identified from the Human Clinical Data
In Vitro Model Mycobacterium smegmatis mc2155 246196
Mycobacterium smegmatis mc2155/pMIP12 246196
Mycobacterium smegmatis mc2155/pOMV20 246196
Mycobacterium smegmatis mc2155/pOMV30 246196
Experiment for
Molecule Alteration		 MALDI mass spectrometry assay
Experiment for
Drug Resistance		 MIC assay
Mechanism Description Erm (38) is a specific dimethyltransferase. The strain obtained drug resistance by adding two methyl groups to A2058 in Mycobacterium 23SrRNA.
Key Molecule: Erythromycin resistance protein (ERM38) [2]
Resistant Disease Mycobacterium smegmatis infection [ICD-11: 1B2Z.3]
Molecule Alteration Expression
Inherence
 Molecule Info 
Resistant Drug Erythromycin
 Drug Info 
Experimental Note Identified from the Human Clinical Data
In Vitro Model Mycobacterium smegmatis mc2155 246196
Mycobacterium smegmatis mc2155/pMIP12 246196
Mycobacterium smegmatis mc2155/pOMV20 246196
Mycobacterium smegmatis mc2155/pOMV30 246196
Experiment for
Molecule Alteration		 MALDI mass spectrometry assay
Experiment for
Drug Resistance		 MIC assay
Mechanism Description Erm (38) is a specific dimethyltransferase. The strain obtained drug resistance by adding two methyl groups to A2058 in Mycobacterium 23SrRNA.
       Irregularity in Drug Uptake and Drug Efflux (IDUE) Click to Show/Hide
Key Molecule: Lincomycin resistance efflux pump (LMRS) [1]
Resistant Disease Staphylococcus aureus infection [ICD-11: 1B54.0]
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Resistant Drug Erythromycin
 Drug Info 
Experimental Note Identified from the Human Clinical Data
In Vitro Model Escherichia coli kAM32 562
Staphylococcus aureus OM505 1280
Experiment for
Molecule Alteration		 Whole genome sequence assay; Allelic frequency measurement assay
Experiment for
Drug Resistance		 Broth microdilution method assay
Mechanism Description LmrS is a multidrug efflux pump of the major facilitator superfamily from staphylococcus aureus.
Florfenicol
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Irregularity in Drug Uptake and Drug Efflux (IDUE) Click to Show/Hide
Key Molecule: Lincomycin resistance efflux pump (LMRS) [1]
Resistant Disease Staphylococcus aureus infection [ICD-11: 1B54.0]
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Resistant Drug Florfenicol
 Drug Info 
Experimental Note Identified from the Human Clinical Data
In Vitro Model Escherichia coli kAM32 562
Staphylococcus aureus OM505 1280
Experiment for
Molecule Alteration		 Whole genome sequence assay; Allelic frequency measurement assay
Experiment for
Drug Resistance		 Broth microdilution method assay
Mechanism Description LmrS is a multidrug efflux pump of the major facilitator superfamily from staphylococcus aureus.
Kanamycin
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Irregularity in Drug Uptake and Drug Efflux (IDUE) Click to Show/Hide
Key Molecule: Lincomycin resistance efflux pump (LMRS) [1]
Resistant Disease Staphylococcus aureus infection [ICD-11: 1B54.0]
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Resistant Drug Kanamycin
 Drug Info 
Experimental Note Identified from the Human Clinical Data
In Vitro Model Escherichia coli kAM32 562
Staphylococcus aureus OM505 1280
Experiment for
Molecule Alteration		 Whole genome sequence assay; Allelic frequency measurement assay
Experiment for
Drug Resistance		 Broth microdilution method assay
Mechanism Description LmrS is a multidrug efflux pump of the major facilitator superfamily from staphylococcus aureus.
Linezolid
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Irregularity in Drug Uptake and Drug Efflux (IDUE) Click to Show/Hide
Key Molecule: Lincomycin resistance efflux pump (LMRS) [1]
Resistant Disease Staphylococcus aureus infection [ICD-11: 1B54.0]
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Resistant Drug Linezolid
 Drug Info 
Experimental Note Identified from the Human Clinical Data
In Vitro Model Escherichia coli kAM32 562
Staphylococcus aureus OM505 1280
Experiment for
Molecule Alteration		 Whole genome sequence assay; Allelic frequency measurement assay
Experiment for
Drug Resistance		 Broth microdilution method assay
Mechanism Description LmrS is a multidrug efflux pump of the major facilitator superfamily from staphylococcus aureus.
Quinupristin
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Aberration of the Drug's Therapeutic Target (ADTT) Click to Show/Hide
Key Molecule: Erythromycin resistance protein (ERM38) [2]
Resistant Disease Mycobacterium smegmatis infection [ICD-11: 1B2Z.3]
Molecule Alteration Expression
Inherence
 Molecule Info 
Resistant Drug Quinupristin
 Drug Info 
Experimental Note Identified from the Human Clinical Data
In Vitro Model Mycobacterium smegmatis mc2155 246196
Mycobacterium smegmatis mc2155/pMIP12 246196
Mycobacterium smegmatis mc2155/pOMV20 246196
Mycobacterium smegmatis mc2155/pOMV30 246196
Experiment for
Molecule Alteration		 MALDI mass spectrometry assay
Experiment for
Drug Resistance		 MIC assay
Mechanism Description Erm (38) is a specific dimethyltransferase. The strain obtained drug resistance by adding two methyl groups to A2058 in Mycobacterium 23SrRNA.
Key Molecule: Erythromycin resistance protein (ERM38) [2]
Resistant Disease Mycobacterium smegmatis infection [ICD-11: 1B2Z.3]
Molecule Alteration Expression
Inherence
 Molecule Info 
Resistant Drug Quinupristin
 Drug Info 
Experimental Note Identified from the Human Clinical Data
In Vitro Model Mycobacterium smegmatis mc2155 246196
Mycobacterium smegmatis mc2155/pMIP12 246196
Mycobacterium smegmatis mc2155/pOMV20 246196
Mycobacterium smegmatis mc2155/pOMV30 246196
Experiment for
Molecule Alteration		 MALDI mass spectrometry assay
Experiment for
Drug Resistance		 MIC assay
Mechanism Description Erm (38) is a specific dimethyltransferase. The strain obtained drug resistance by adding two methyl groups to A2058 in Mycobacterium 23SrRNA.
Streptomycin
Click to Show/Hide
Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Irregularity in Drug Uptake and Drug Efflux (IDUE) Click to Show/Hide
Key Molecule: Lincomycin resistance efflux pump (LMRS) [1]
Resistant Disease Staphylococcus aureus infection [ICD-11: 1B54.0]
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Resistant Drug Streptomycin
 Drug Info 
Experimental Note Identified from the Human Clinical Data
In Vitro Model Escherichia coli kAM32 562
Staphylococcus aureus OM505 1280
Experiment for
Molecule Alteration		 Whole genome sequence assay; Allelic frequency measurement assay
Experiment for
Drug Resistance		 Broth microdilution method assay
Mechanism Description LmrS is a multidrug efflux pump of the major facilitator superfamily from staphylococcus aureus.
Telithromycin
Click to Show/Hide
Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Aberration of the Drug's Therapeutic Target (ADTT) Click to Show/Hide
Key Molecule: Erythromycin resistance protein (ERM38) [2]
Resistant Disease Mycobacterium smegmatis infection [ICD-11: 1B2Z.3]
Molecule Alteration Expression
Inherence
 Molecule Info 
Resistant Drug Telithromycin
 Drug Info 
Experimental Note Identified from the Human Clinical Data
In Vitro Model Mycobacterium smegmatis mc2155 246196
Mycobacterium smegmatis mc2155/pMIP12 246196
Mycobacterium smegmatis mc2155/pOMV20 246196
Mycobacterium smegmatis mc2155/pOMV30 246196
Experiment for
Molecule Alteration		 MALDI mass spectrometry assay
Experiment for
Drug Resistance		 MIC assay
Mechanism Description Erm (38) is a specific dimethyltransferase. The strain obtained drug resistance by adding two methyl groups to A2058 in Mycobacterium 23SrRNA.
Key Molecule: Erythromycin resistance protein (ERM38) [2]
Resistant Disease Mycobacterium smegmatis infection [ICD-11: 1B2Z.3]
Molecule Alteration Expression
Inherence
 Molecule Info 
Resistant Drug Telithromycin
 Drug Info 
Experimental Note Identified from the Human Clinical Data
In Vitro Model Mycobacterium smegmatis mc2155 246196
Mycobacterium smegmatis mc2155/pMIP12 246196
Mycobacterium smegmatis mc2155/pOMV20 246196
Mycobacterium smegmatis mc2155/pOMV30 246196
Experiment for
Molecule Alteration		 MALDI mass spectrometry assay
Experiment for
Drug Resistance		 MIC assay
Mechanism Description Erm (38) is a specific dimethyltransferase. The strain obtained drug resistance by adding two methyl groups to A2058 in Mycobacterium 23SrRNA.
Trimethoprim
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Irregularity in Drug Uptake and Drug Efflux (IDUE) Click to Show/Hide
Key Molecule: Lincomycin resistance efflux pump (LMRS) [1]
Resistant Disease Staphylococcus aureus infection [ICD-11: 1B54.0]
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Resistant Drug Trimethoprim
 Drug Info 
Experimental Note Identified from the Human Clinical Data
In Vitro Model Escherichia coli kAM32 562
Staphylococcus aureus OM505 1280
Experiment for
Molecule Alteration		 Whole genome sequence assay; Allelic frequency measurement assay
Experiment for
Drug Resistance		 Broth microdilution method assay
Mechanism Description LmrS is a multidrug efflux pump of the major facilitator superfamily from staphylococcus aureus.
References
Ref 1 LmrS is a multidrug efflux pump of the major facilitator superfamily from Staphylococcus aureus. Antimicrob Agents Chemother. 2010 Dec;54(12):5406-12. doi: 10.1128/AAC.00580-10. Epub 2010 Sep 20.
Ref 2 Mycobacterium smegmatis Erm(38) is a reluctant dimethyltransferase. Antimicrob Agents Chemother. 2005 Sep;49(9):3803-9. doi: 10.1128/AAC.49.9.3803-3809.2005.

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