Molecule Information

General Information of the Molecule (ID: Mol00960)
Name
Erythromycin resistance protein (ERM38) ,Mycolicibacterium smegmatis
Synonyms
erm(38); 38
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Molecule Type
Protein
Gene Name
erm(38)
Sequence
MSTPHHGRHELGQNFLSDRRVIADIVEIVSRTNGPIIEIGAGDGALTIPLQRLARPLTAV
EVDARRARRLAQRTARSAPGPASRPTEVVAADFLRYPLPRSPHVVVGNLPFHLTTAILRR
LLHGPGWTTAVLLMQWEVARRRAAVGGATMMTAQWWPWFEFGLARKVSAASFTPRPAVDA
GLLTITRRSRPLVDVADRARYQALVHRVFTGRGHGMAQILQRLPTPVPRTWLRANGIAPN
SLPRQLSAAQWAALFEQTRLTGAQRVDRPRDVQHGRAHRRRGGEVDRPATHHKQTGPVVG
QRQPQRGRDADADPDDQRTAPPVTRHHQGERRDEDQADHQDRPLTGEHLAGEFLWRHASF
DSSASTTLVSRKARVNGPTPPGLGDT
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Uniprot ID
Q79N53_MYCSM
        Click to Show/Hide the Complete Species Lineage
Kingdom: N.A.
Phylum: Actinobacteria
Class: Actinomycetia
Order: Corynebacteriales
Family: Mycobacteriaceae
Genus: Mycolicibacterium
Species: Mycolicibacterium smegmatis
Type(s) of Resistant Mechanism of This Molecule
  ADTT: Aberration of the Drug's Therapeutic Target
Drug Resistance Data Categorized by Drug
Approved Drug(s)
5 drug(s) in total
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Clarithromycin
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Aberration of the Drug's Therapeutic Target (ADTT) Click to Show/Hide
Disease Class: Mycobacterium smegmatis infection [1]
Resistant Disease Mycobacterium smegmatis infection [ICD-11: 1B2Z.3]
 Disease Info 
Resistant Drug Clarithromycin
 Drug Info 
Molecule Alteration Expression
Inherence
Experimental Note Identified from the Human Clinical Data
In Vitro Model Mycobacterium smegmatis mc2155 246196
Mycobacterium smegmatis mc2155/pMIP12 246196
Mycobacterium smegmatis mc2155/pOMV20 246196
Mycobacterium smegmatis mc2155/pOMV30 246196
Experiment for
Molecule Alteration		 MALDI mass spectrometry assay
Experiment for
Drug Resistance		 MIC assay
Mechanism Description Erm (38) is a specific dimethyltransferase. The strain obtained drug resistance by adding two methyl groups to A2058 in Mycobacterium 23SrRNA.
Disease Class: Mycobacterium smegmatis infection [1]
Resistant Disease Mycobacterium smegmatis infection [ICD-11: 1B2Z.3]
 Disease Info 
Resistant Drug Clarithromycin
 Drug Info 
Molecule Alteration Expression
Inherence
Experimental Note Identified from the Human Clinical Data
In Vitro Model Mycobacterium smegmatis mc2155 246196
Mycobacterium smegmatis mc2155/pMIP12 246196
Mycobacterium smegmatis mc2155/pOMV20 246196
Mycobacterium smegmatis mc2155/pOMV30 246196
Experiment for
Molecule Alteration		 MALDI mass spectrometry assay
Experiment for
Drug Resistance		 MIC assay
Mechanism Description Erm (38) is a specific dimethyltransferase. The strain obtained drug resistance by adding two methyl groups to A2058 in Mycobacterium 23SrRNA.
Clindamycin
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Aberration of the Drug's Therapeutic Target (ADTT) Click to Show/Hide
Disease Class: Mycobacterium smegmatis infection [1]
Resistant Disease Mycobacterium smegmatis infection [ICD-11: 1B2Z.3]
 Disease Info 
Resistant Drug Clindamycin
 Drug Info 
Molecule Alteration Expression
Inherence
Experimental Note Identified from the Human Clinical Data
In Vitro Model Mycobacterium smegmatis mc2155 246196
Mycobacterium smegmatis mc2155/pMIP12 246196
Mycobacterium smegmatis mc2155/pOMV20 246196
Mycobacterium smegmatis mc2155/pOMV30 246196
Experiment for
Molecule Alteration		 MALDI mass spectrometry assay
Experiment for
Drug Resistance		 MIC assay
Mechanism Description Erm (38) is a specific dimethyltransferase. The strain obtained drug resistance by adding two methyl groups to A2058 in Mycobacterium 23SrRNA.
Disease Class: Mycobacterium smegmatis infection [1]
Resistant Disease Mycobacterium smegmatis infection [ICD-11: 1B2Z.3]
 Disease Info 
Resistant Drug Clindamycin
 Drug Info 
Molecule Alteration Expression
Inherence
Experimental Note Identified from the Human Clinical Data
In Vitro Model Mycobacterium smegmatis mc2155 246196
Mycobacterium smegmatis mc2155/pMIP12 246196
Mycobacterium smegmatis mc2155/pOMV20 246196
Mycobacterium smegmatis mc2155/pOMV30 246196
Experiment for
Molecule Alteration		 MALDI mass spectrometry assay
Experiment for
Drug Resistance		 MIC assay
Mechanism Description Erm (38) is a specific dimethyltransferase. The strain obtained drug resistance by adding two methyl groups to A2058 in Mycobacterium 23SrRNA.
Erythromycin
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Aberration of the Drug's Therapeutic Target (ADTT) Click to Show/Hide
Disease Class: Mycobacterium smegmatis infection [1]
Resistant Disease Mycobacterium smegmatis infection [ICD-11: 1B2Z.3]
 Disease Info 
Resistant Drug Erythromycin
 Drug Info 
Molecule Alteration Expression
Inherence
Experimental Note Identified from the Human Clinical Data
In Vitro Model Mycobacterium smegmatis mc2155 246196
Mycobacterium smegmatis mc2155/pMIP12 246196
Mycobacterium smegmatis mc2155/pOMV20 246196
Mycobacterium smegmatis mc2155/pOMV30 246196
Experiment for
Molecule Alteration		 MALDI mass spectrometry assay
Experiment for
Drug Resistance		 MIC assay
Mechanism Description Erm (38) is a specific dimethyltransferase. The strain obtained drug resistance by adding two methyl groups to A2058 in Mycobacterium 23SrRNA.
Disease Class: Mycobacterium smegmatis infection [1]
Resistant Disease Mycobacterium smegmatis infection [ICD-11: 1B2Z.3]
 Disease Info 
Resistant Drug Erythromycin
 Drug Info 
Molecule Alteration Expression
Inherence
Experimental Note Identified from the Human Clinical Data
In Vitro Model Mycobacterium smegmatis mc2155 246196
Mycobacterium smegmatis mc2155/pMIP12 246196
Mycobacterium smegmatis mc2155/pOMV20 246196
Mycobacterium smegmatis mc2155/pOMV30 246196
Experiment for
Molecule Alteration		 MALDI mass spectrometry assay
Experiment for
Drug Resistance		 MIC assay
Mechanism Description Erm (38) is a specific dimethyltransferase. The strain obtained drug resistance by adding two methyl groups to A2058 in Mycobacterium 23SrRNA.
Quinupristin
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Aberration of the Drug's Therapeutic Target (ADTT) Click to Show/Hide
Disease Class: Mycobacterium smegmatis infection [1]
Resistant Disease Mycobacterium smegmatis infection [ICD-11: 1B2Z.3]
 Disease Info 
Resistant Drug Quinupristin
 Drug Info 
Molecule Alteration Expression
Inherence
Experimental Note Identified from the Human Clinical Data
In Vitro Model Mycobacterium smegmatis mc2155 246196
Mycobacterium smegmatis mc2155/pMIP12 246196
Mycobacterium smegmatis mc2155/pOMV20 246196
Mycobacterium smegmatis mc2155/pOMV30 246196
Experiment for
Molecule Alteration		 MALDI mass spectrometry assay
Experiment for
Drug Resistance		 MIC assay
Mechanism Description Erm (38) is a specific dimethyltransferase. The strain obtained drug resistance by adding two methyl groups to A2058 in Mycobacterium 23SrRNA.
Disease Class: Mycobacterium smegmatis infection [1]
Resistant Disease Mycobacterium smegmatis infection [ICD-11: 1B2Z.3]
 Disease Info 
Resistant Drug Quinupristin
 Drug Info 
Molecule Alteration Expression
Inherence
Experimental Note Identified from the Human Clinical Data
In Vitro Model Mycobacterium smegmatis mc2155 246196
Mycobacterium smegmatis mc2155/pMIP12 246196
Mycobacterium smegmatis mc2155/pOMV20 246196
Mycobacterium smegmatis mc2155/pOMV30 246196
Experiment for
Molecule Alteration		 MALDI mass spectrometry assay
Experiment for
Drug Resistance		 MIC assay
Mechanism Description Erm (38) is a specific dimethyltransferase. The strain obtained drug resistance by adding two methyl groups to A2058 in Mycobacterium 23SrRNA.
Telithromycin
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Aberration of the Drug's Therapeutic Target (ADTT) Click to Show/Hide
Disease Class: Mycobacterium smegmatis infection [1]
Resistant Disease Mycobacterium smegmatis infection [ICD-11: 1B2Z.3]
 Disease Info 
Resistant Drug Telithromycin
 Drug Info 
Molecule Alteration Expression
Inherence
Experimental Note Identified from the Human Clinical Data
In Vitro Model Mycobacterium smegmatis mc2155 246196
Mycobacterium smegmatis mc2155/pMIP12 246196
Mycobacterium smegmatis mc2155/pOMV20 246196
Mycobacterium smegmatis mc2155/pOMV30 246196
Experiment for
Molecule Alteration		 MALDI mass spectrometry assay
Experiment for
Drug Resistance		 MIC assay
Mechanism Description Erm (38) is a specific dimethyltransferase. The strain obtained drug resistance by adding two methyl groups to A2058 in Mycobacterium 23SrRNA.
Disease Class: Mycobacterium smegmatis infection [1]
Resistant Disease Mycobacterium smegmatis infection [ICD-11: 1B2Z.3]
 Disease Info 
Resistant Drug Telithromycin
 Drug Info 
Molecule Alteration Expression
Inherence
Experimental Note Identified from the Human Clinical Data
In Vitro Model Mycobacterium smegmatis mc2155 246196
Mycobacterium smegmatis mc2155/pMIP12 246196
Mycobacterium smegmatis mc2155/pOMV20 246196
Mycobacterium smegmatis mc2155/pOMV30 246196
Experiment for
Molecule Alteration		 MALDI mass spectrometry assay
Experiment for
Drug Resistance		 MIC assay
Mechanism Description Erm (38) is a specific dimethyltransferase. The strain obtained drug resistance by adding two methyl groups to A2058 in Mycobacterium 23SrRNA.
References
Ref 1 Mycobacterium smegmatis Erm(38) is a reluctant dimethyltransferase. Antimicrob Agents Chemother. 2005 Sep;49(9):3803-9. doi: 10.1128/AAC.49.9.3803-3809.2005.

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