Disease Information

General Information of the Disease (ID: DIS00100)
Name
Retina cancer
ICD
ICD-11: 2D02
Type(s) of Resistant Mechanism of This Disease
  EADR: Epigenetic Alteration of DNA, RNA or Protein
  IDUE: Irregularity in Drug Uptake and Drug Efflux
  UAPP: Unusual Activation of Pro-survival Pathway
Drug Resistance Data Categorized by Drug
Approved Drug(s)
5 drug(s) in total
Click to Show/Hide the Full List of Drugs
Carboplatin
Click to Show/Hide
Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
       Epigenetic Alteration of DNA, RNA or Protein (EADR) Click to Show/Hide
Key Molecule: hsa-mir-34 [1]
Sensitive Disease Retinoblastoma [ICD-11: 2D02.2]
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Sensitive Drug Carboplatin
 Drug Info 
Experimental Note Revealed Based on the Cell Line Data
Cell Pathway Regulation Cell apoptosis Activation hsa04210
MAGE-A/p53 signaling pathway Regulation hsa04115
In Vitro Model HXO-Rb44 cells Retina Homo sapiens (Human) CVCL_D542
SO-Rb50 cells Retina Homo sapiens (Human) CVCL_D543
WERI-Rb-1 cells Retina Homo sapiens (Human) CVCL_1792
Y79 cells Retina Homo sapiens (Human) CVCL_1893
Experiment for
Molecule Alteration		 RT-qPCR
Experiment for
Drug Resistance		 Freedom Evolyzer-2200 Enzyme-Linked Immunometric meter; Flow cytometry assay
Mechanism Description miR-34a may function as a tumor suppressor for RB by targeting MAGE-A and upregulating p53 expression to enhance cell apoptosis and chemosensitivity (Carboplatin; Etoposide; Adriamycin; vincristine).
Key Molecule: hsa-miR-3163 [2]
Sensitive Disease Retinoblastoma [ICD-11: 2D02.2]
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Sensitive Drug Carboplatin
 Drug Info 
Experimental Note Revealed Based on the Cell Line Data
Cell Pathway Regulation Cell apoptosis Activation hsa04210
Cell proliferation Inhibition hsa05200
In Vitro Model WERI-Rb-1 cells Retina Homo sapiens (Human) CVCL_1792
Experiment for
Molecule Alteration		 RT-PCR
Experiment for
Drug Resistance		 CCK8 assay
Mechanism Description Silencing of ABCG2 by MicroRNA-3163 inhibits multidrug resistance in retinoblastoma cancer stem cells.
       Irregularity in Drug Uptake and Drug Efflux (IDUE) Click to Show/Hide
Key Molecule: ATP-binding cassette sub-family G2 (ABCG2) [2]
Sensitive Disease Retinoblastoma [ICD-11: 2D02.2]
Molecule Alteration Expression
Down-regulation
 Molecule Info 
Sensitive Drug Carboplatin
 Drug Info 
Experimental Note Revealed Based on the Cell Line Data
Cell Pathway Regulation Cell apoptosis Activation hsa04210
Cell proliferation Inhibition hsa05200
In Vitro Model WERI-Rb-1 cells Retina Homo sapiens (Human) CVCL_1792
In Vivo Model Nude mouse xenograft model Mus musculus
Experiment for
Molecule Alteration		 Western blot analysis
Experiment for
Drug Resistance		 CCK8 assay
Mechanism Description Silencing of ABCG2 by MicroRNA-3163 inhibits multidrug resistance in retinoblastoma cancer stem cells.
       Unusual Activation of Pro-survival Pathway (UAPP) Click to Show/Hide
Key Molecule: Melanoma antigen A 4 (MAGE4) [1]
Sensitive Disease Retinoblastoma [ICD-11: 2D02.2]
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Sensitive Drug Carboplatin
 Drug Info 
Experimental Note Revealed Based on the Cell Line Data
Cell Pathway Regulation Cell apoptosis Activation hsa04210
MAGE-A/p53 signaling pathway Regulation hsa04115
In Vitro Model HXO-Rb44 cells Retina Homo sapiens (Human) CVCL_D542
SO-Rb50 cells Retina Homo sapiens (Human) CVCL_D543
WERI-Rb-1 cells Retina Homo sapiens (Human) CVCL_1792
Y79 cells Retina Homo sapiens (Human) CVCL_1893
Experiment for
Molecule Alteration		 Western blot analysis; RT-qPCR
Experiment for
Drug Resistance		 Freedom Evolyzer-2200 Enzyme-Linked Immunometric meter; Flow cytometry assay
Mechanism Description miR-34a may function as a tumor suppressor for RB by targeting MAGE-A and upregulating p53 expression to enhance cell apoptosis and chemosensitivity (Carboplatin; Etoposide; Adriamycin; vincristine).
Cisplatin
Click to Show/Hide
Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
       Epigenetic Alteration of DNA, RNA or Protein (EADR) Click to Show/Hide
Key Molecule: hsa-miR-3163 [2]
Sensitive Disease Retinoblastoma [ICD-11: 2D02.2]
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Sensitive Drug Cisplatin
 Drug Info 
Experimental Note Revealed Based on the Cell Line Data
Cell Pathway Regulation Cell apoptosis Activation hsa04210
Cell proliferation Inhibition hsa05200
In Vitro Model WERI-Rb-1 cells Retina Homo sapiens (Human) CVCL_1792
Experiment for
Molecule Alteration		 RT-PCR
Experiment for
Drug Resistance		 CCK8 assay
Mechanism Description Silencing of ABCG2 by MicroRNA-3163 inhibits multidrug resistance in retinoblastoma cancer stem cells.
       Irregularity in Drug Uptake and Drug Efflux (IDUE) Click to Show/Hide
Key Molecule: ATP-binding cassette sub-family G2 (ABCG2) [2]
Sensitive Disease Retinoblastoma [ICD-11: 2D02.2]
Molecule Alteration Expression
Down-regulation
 Molecule Info 
Sensitive Drug Cisplatin
 Drug Info 
Experimental Note Revealed Based on the Cell Line Data
Cell Pathway Regulation Cell apoptosis Activation hsa04210
Cell proliferation Inhibition hsa05200
In Vitro Model WERI-Rb-1 cells Retina Homo sapiens (Human) CVCL_1792
In Vivo Model Nude mouse xenograft model Mus musculus
Experiment for
Molecule Alteration		 Western blot analysis
Experiment for
Drug Resistance		 CCK8 assay
Mechanism Description Silencing of ABCG2 by MicroRNA-3163 inhibits multidrug resistance in retinoblastoma cancer stem cells.
Doxorubicin
Click to Show/Hide
Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
       Epigenetic Alteration of DNA, RNA or Protein (EADR) Click to Show/Hide
Key Molecule: hsa-mir-34 [1]
Sensitive Disease Retinoblastoma [ICD-11: 2D02.2]
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Sensitive Drug Doxorubicin
 Drug Info 
Experimental Note Revealed Based on the Cell Line Data
Cell Pathway Regulation Cell apoptosis Activation hsa04210
MAGE-A/p53 signaling pathway Regulation hsa04115
In Vitro Model HXO-Rb44 cells Retina Homo sapiens (Human) CVCL_D542
SO-Rb50 cells Retina Homo sapiens (Human) CVCL_D543
WERI-Rb-1 cells Retina Homo sapiens (Human) CVCL_1792
Y79 cells Retina Homo sapiens (Human) CVCL_1893
Experiment for
Molecule Alteration		 RT-qPCR
Experiment for
Drug Resistance		 Freedom Evolyzer-2200 Enzyme-Linked Immunometric meter; Flow cytometry assay
Mechanism Description miR-34a may function as a tumor suppressor for RB by targeting MAGE-A and upregulating p53 expression to enhance cell apoptosis and chemosensitivity (Carboplatin; Etoposide; Adriamycin; vincristine).
Key Molecule: hsa-miR-3163 [2]
Sensitive Disease Retinoblastoma [ICD-11: 2D02.2]
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Sensitive Drug Doxorubicin
 Drug Info 
Experimental Note Revealed Based on the Cell Line Data
Cell Pathway Regulation Cell apoptosis Activation hsa04210
Cell proliferation Inhibition hsa05200
In Vitro Model WERI-Rb-1 cells Retina Homo sapiens (Human) CVCL_1792
Experiment for
Molecule Alteration		 RT-PCR
Experiment for
Drug Resistance		 CCK8 assay
Mechanism Description Silencing of ABCG2 by MicroRNA-3163 inhibits multidrug resistance in retinoblastoma cancer stem cells.
       Irregularity in Drug Uptake and Drug Efflux (IDUE) Click to Show/Hide
Key Molecule: ATP-binding cassette sub-family G2 (ABCG2) [2]
Sensitive Disease Retinoblastoma [ICD-11: 2D02.2]
Molecule Alteration Expression
Down-regulation
 Molecule Info 
Sensitive Drug Doxorubicin
 Drug Info 
Experimental Note Revealed Based on the Cell Line Data
Cell Pathway Regulation Cell apoptosis Activation hsa04210
Cell proliferation Inhibition hsa05200
In Vitro Model WERI-Rb-1 cells Retina Homo sapiens (Human) CVCL_1792
In Vivo Model Nude mouse xenograft model Mus musculus
Experiment for
Molecule Alteration		 Western blot analysis
Experiment for
Drug Resistance		 CCK8 assay
Mechanism Description Silencing of ABCG2 by MicroRNA-3163 inhibits multidrug resistance in retinoblastoma cancer stem cells.
       Unusual Activation of Pro-survival Pathway (UAPP) Click to Show/Hide
Key Molecule: Melanoma antigen A 4 (MAGE4) [1]
Sensitive Disease Retinoblastoma [ICD-11: 2D02.2]
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Sensitive Drug Doxorubicin
 Drug Info 
Experimental Note Revealed Based on the Cell Line Data
Cell Pathway Regulation Cell apoptosis Activation hsa04210
MAGE-A/p53 signaling pathway Regulation hsa04115
In Vitro Model HXO-Rb44 cells Retina Homo sapiens (Human) CVCL_D542
SO-Rb50 cells Retina Homo sapiens (Human) CVCL_D543
WERI-Rb-1 cells Retina Homo sapiens (Human) CVCL_1792
Y79 cells Retina Homo sapiens (Human) CVCL_1893
Experiment for
Molecule Alteration		 Western blot analysis; RT-qPCR
Experiment for
Drug Resistance		 Freedom Evolyzer-2200 Enzyme-Linked Immunometric meter; Flow cytometry assay
Mechanism Description miR-34a may function as a tumor suppressor for RB by targeting MAGE-A and upregulating p53 expression to enhance cell apoptosis and chemosensitivity (Carboplatin; Etoposide; Adriamycin; vincristine).
Etoposide
Click to Show/Hide
Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
       Epigenetic Alteration of DNA, RNA or Protein (EADR) Click to Show/Hide
Key Molecule: hsa-mir-34 [1]
Sensitive Disease Retinoblastoma [ICD-11: 2D02.2]
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Sensitive Drug Etoposide
 Drug Info 
Experimental Note Revealed Based on the Cell Line Data
Cell Pathway Regulation Cell apoptosis Activation hsa04210
MAGE-A/p53 signaling pathway Regulation hsa04115
In Vitro Model HXO-Rb44 cells Retina Homo sapiens (Human) CVCL_D542
SO-Rb50 cells Retina Homo sapiens (Human) CVCL_D543
WERI-Rb-1 cells Retina Homo sapiens (Human) CVCL_1792
Y79 cells Retina Homo sapiens (Human) CVCL_1893
Experiment for
Molecule Alteration		 RT-qPCR
Experiment for
Drug Resistance		 Freedom Evolyzer-2200 Enzyme-Linked Immunometric meter; Flow cytometry assay
Mechanism Description miR-34a may function as a tumor suppressor for RB by targeting MAGE-A and upregulating p53 expression to enhance cell apoptosis and chemosensitivity (Carboplatin; Etoposide; Adriamycin; vincristine).
Key Molecule: hsa-miR-3163 [2]
Sensitive Disease Retinoblastoma [ICD-11: 2D02.2]
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Sensitive Drug Etoposide
 Drug Info 
Experimental Note Revealed Based on the Cell Line Data
Cell Pathway Regulation Cell apoptosis Activation hsa04210
Cell proliferation Inhibition hsa05200
In Vitro Model WERI-Rb-1 cells Retina Homo sapiens (Human) CVCL_1792
Experiment for
Molecule Alteration		 RT-PCR
Experiment for
Drug Resistance		 CCK8 assay
Mechanism Description Silencing of ABCG2 by MicroRNA-3163 inhibits multidrug resistance in retinoblastoma cancer stem cells.
       Irregularity in Drug Uptake and Drug Efflux (IDUE) Click to Show/Hide
Key Molecule: ATP-binding cassette sub-family G2 (ABCG2) [2]
Sensitive Disease Retinoblastoma [ICD-11: 2D02.2]
Molecule Alteration Expression
Down-regulation
 Molecule Info 
Sensitive Drug Etoposide
 Drug Info 
Experimental Note Revealed Based on the Cell Line Data
Cell Pathway Regulation Cell apoptosis Activation hsa04210
Cell proliferation Inhibition hsa05200
In Vitro Model WERI-Rb-1 cells Retina Homo sapiens (Human) CVCL_1792
In Vivo Model Nude mouse xenograft model Mus musculus
Experiment for
Molecule Alteration		 Western blot analysis
Experiment for
Drug Resistance		 CCK8 assay
Mechanism Description Silencing of ABCG2 by MicroRNA-3163 inhibits multidrug resistance in retinoblastoma cancer stem cells.
       Unusual Activation of Pro-survival Pathway (UAPP) Click to Show/Hide
Key Molecule: Melanoma antigen A 4 (MAGE4) [1]
Sensitive Disease Retinoblastoma [ICD-11: 2D02.2]
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Sensitive Drug Etoposide
 Drug Info 
Experimental Note Revealed Based on the Cell Line Data
Cell Pathway Regulation Cell apoptosis Activation hsa04210
MAGE-A/p53 signaling pathway Regulation hsa04115
In Vitro Model HXO-Rb44 cells Retina Homo sapiens (Human) CVCL_D542
SO-Rb50 cells Retina Homo sapiens (Human) CVCL_D543
WERI-Rb-1 cells Retina Homo sapiens (Human) CVCL_1792
Y79 cells Retina Homo sapiens (Human) CVCL_1893
Experiment for
Molecule Alteration		 Western blot analysis; RT-qPCR
Experiment for
Drug Resistance		 Freedom Evolyzer-2200 Enzyme-Linked Immunometric meter; Flow cytometry assay
Mechanism Description miR-34a may function as a tumor suppressor for RB by targeting MAGE-A and upregulating p53 expression to enhance cell apoptosis and chemosensitivity (Carboplatin; Etoposide; Adriamycin; vincristine).
Vincristine
Click to Show/Hide
Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
       Epigenetic Alteration of DNA, RNA or Protein (EADR) Click to Show/Hide
Key Molecule: hsa-mir-34 [1]
Sensitive Disease Retinoblastoma [ICD-11: 2D02.2]
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Sensitive Drug Vincristine
 Drug Info 
Experimental Note Revealed Based on the Cell Line Data
Cell Pathway Regulation Cell apoptosis Activation hsa04210
MAGE-A/p53 signaling pathway Regulation hsa04115
In Vitro Model HXO-Rb44 cells Retina Homo sapiens (Human) CVCL_D542
SO-Rb50 cells Retina Homo sapiens (Human) CVCL_D543
WERI-Rb-1 cells Retina Homo sapiens (Human) CVCL_1792
Y79 cells Retina Homo sapiens (Human) CVCL_1893
Experiment for
Molecule Alteration		 RT-qPCR
Experiment for
Drug Resistance		 Freedom Evolyzer-2200 Enzyme-Linked Immunometric meter; Flow cytometry assay
Mechanism Description miR-34a may function as a tumor suppressor for RB by targeting MAGE-A and upregulating p53 expression to enhance cell apoptosis and chemosensitivity (Carboplatin; Etoposide; Adriamycin; vincristine).
Key Molecule: hsa-miR-3163 [2]
Sensitive Disease Retinoblastoma [ICD-11: 2D02.2]
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Sensitive Drug Vincristine
 Drug Info 
Experimental Note Revealed Based on the Cell Line Data
Cell Pathway Regulation Cell apoptosis Activation hsa04210
Cell proliferation Inhibition hsa05200
In Vitro Model WERI-Rb-1 cells Retina Homo sapiens (Human) CVCL_1792
Experiment for
Molecule Alteration		 RT-PCR
Experiment for
Drug Resistance		 CCK8 assay
Mechanism Description Silencing of ABCG2 by MicroRNA-3163 inhibits multidrug resistance in retinoblastoma cancer stem cells.
       Irregularity in Drug Uptake and Drug Efflux (IDUE) Click to Show/Hide
Key Molecule: ATP-binding cassette sub-family G2 (ABCG2) [2]
Sensitive Disease Retinoblastoma [ICD-11: 2D02.2]
Molecule Alteration Expression
Down-regulation
 Molecule Info 
Sensitive Drug Vincristine
 Drug Info 
Experimental Note Revealed Based on the Cell Line Data
Cell Pathway Regulation Cell apoptosis Activation hsa04210
Cell proliferation Inhibition hsa05200
In Vitro Model WERI-Rb-1 cells Retina Homo sapiens (Human) CVCL_1792
In Vivo Model Nude mouse xenograft model Mus musculus
Experiment for
Molecule Alteration		 Western blot analysis
Experiment for
Drug Resistance		 CCK8 assay
Mechanism Description Silencing of ABCG2 by MicroRNA-3163 inhibits multidrug resistance in retinoblastoma cancer stem cells.
       Unusual Activation of Pro-survival Pathway (UAPP) Click to Show/Hide
Key Molecule: Melanoma antigen A 4 (MAGE4) [1]
Sensitive Disease Retinoblastoma [ICD-11: 2D02.2]
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Sensitive Drug Vincristine
 Drug Info 
Experimental Note Revealed Based on the Cell Line Data
Cell Pathway Regulation Cell apoptosis Activation hsa04210
MAGE-A/p53 signaling pathway Regulation hsa04115
In Vitro Model HXO-Rb44 cells Retina Homo sapiens (Human) CVCL_D542
SO-Rb50 cells Retina Homo sapiens (Human) CVCL_D543
WERI-Rb-1 cells Retina Homo sapiens (Human) CVCL_1792
Y79 cells Retina Homo sapiens (Human) CVCL_1893
Experiment for
Molecule Alteration		 Western blot analysis; RT-qPCR
Experiment for
Drug Resistance		 Freedom Evolyzer-2200 Enzyme-Linked Immunometric meter; Flow cytometry assay
Mechanism Description miR-34a may function as a tumor suppressor for RB by targeting MAGE-A and upregulating p53 expression to enhance cell apoptosis and chemosensitivity (Carboplatin; Etoposide; Adriamycin; vincristine).
References
Ref 1 miR 34a regulates the chemosensitivity of retinoblastoma cells via modulation of MAGE A/p53 signaling. Int J Oncol. 2019 Jan;54(1):177-187. doi: 10.3892/ijo.2018.4613. Epub 2018 Oct 31.
Ref 2 Silencing of ABCG2 by MicroRNA-3163 Inhibits Multidrug Resistance in Retinoblastoma Cancer Stem Cells. J Korean Med Sci. 2016 Jun;31(6):836-42. doi: 10.3346/jkms.2016.31.6.836. Epub 2016 Apr 20.

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