Drug Information

Drug (ID: DG01041) and It's Reported Resistant Information
Name
Fluvastatin
Synonyms
Fluvastatin; Lescol; 93957-54-1; (3R,5S)-fluvastatin; Canef; Cranoc; (3R,5S,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid; (+)-(3R,5S)-fluvastatin; XU-62320; CHEBI:38565; 155229-75-7; Vastin; (+)-3R,5S-Fluvastatin sodium salt; (3R,5S,6E)-7-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid; (3R,5S,E)-7-(3-(4-Fluorophenyl)-1-isopropyl-1H-indol-2-yl)-3,5-dihydroxyhept-6-enoic acid; (E,3R,5S)-7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoic acid; (3R,5S,6E)-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid; CHEMBL1078; Fluvastatin & Primycin; NSC-758896; (-)-fluvastatin; (E,3R,5S)-7-[3-(4-fluorophenyl)-1-isopropyl-indol-2-yl]-3,5-dihydroxy-hept-6-enoic acid; DSSTox_CID_636; Prestwick2_000859; SCHEMBL2846; DSSTox_RID_75707; DSSTox_GSID_20636; (3R,5S,6E)-rel-7-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid; SCHEMBL556754; GTPL2951; DTXSID2020636; BDBM86704; CHEBI:93160; HMS2089P06; HMS3259J15; Pharmakon1600-01504911; ACT03305; ZINC1886617; Tox21_302765; DL-108; HY-14664B; NSC758896; CCG-213323; NC00659; NCGC00256490-01; CAS-93957-54-1; CAS_93957-54-1; CS-0019897; EN300-51915; H11963; 957F541; Q417942; SR-05000001489-1; BRD-K66296774-001-02-0; UNII-4L066368AS component FJLGEFLZQAZZCD-MCBHFWOFSA-N; (E)-(3R,5S)-7-[3-(4-Fluoro-phenyl)-1-isopropyl-1H-indol-2-yl]-3,5-dihydroxy-hept-6-enoic acid; 6-Heptenoic acid, 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-, (3R,5S,6E)-; Fluvastatin sodium L1483
    Click to Show/Hide
Indication
In total 1 Indication(s)
Hypercholesterolaemia [ICD-11: 5C80]
Approved
[1]
Structure
Drug Resistance Disease(s)
Disease(s) with Resistance Information Validated by in-vivo Model for This Drug (1 diseases)
Breast cancer [ICD-11: 2C60]
[1]
Target HMG-CoA reductase (HMGCR) HMDH_HUMAN [1]
Click to Show/Hide the Molecular Information and External Link(s) of This Drug
Formula
C24H26FNO4
IsoSMILES
CC(C)N1C2=CC=CC=C2C(=C1/C=C/[C@H](C[C@H](CC(=O)O)O)O)C3=CC=C(C=C3)F
InChI
1S/C24H26FNO4/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30)/b12-11+/t18-,19-/m1/s1
InChIKey
FJLGEFLZQAZZCD-MCBHFWOFSA-N
PubChem CID
446155
ChEBI ID
CHEBI:38565
TTD Drug ID
D08GHB
VARIDT ID
DR00124
DrugBank ID
DB01095
Type(s) of Resistant Mechanism of This Drug
  DISM: Drug Inactivation by Structure Modification
  UAPP: Unusual Activation of Pro-survival Pathway
Drug Resistance Data Categorized by Their Corresponding Diseases
ICD-02: Benign/in-situ/malignant neoplasm
Click to Show/Hide the Resistance Disease of This Class
Breast cancer [ICD-11: 2C60]
Click to Show/Hide
Drug Resistance Data Categorized by Their Corresponding Mechanisms
  Unusual Activation of Pro-survival Pathway (UAPP) Click to Show/Hide
Key Molecule: Mevalonate kinase (MVK) [1]
Resistant Disease Breast cancer [ICD-11: 2C60.3]
 Disease Info 
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Differential expression of the molecule in resistant disease
Classification of Disease Breast cancer [ICD-11: 2C60]
The Specified Disease Breast cancer
The Studied Tissue Breast tissue
The Expression Level of Disease Section Compare with the Healthy Individual Tissue
p-value: 5.91E-02
Fold-change: 9.75E-03
Z-score: 1.89E+00
Experimental Note Discovered Using In-vivo Testing Model
Cell Pathway Regulation Steroid biosynthesis signaling pathway Activation hsa00100
Terpenoid bacKbone biosynthesis signaling pathway Activation hsa00900
Steroid hormone biosynthesis signaling pathway Activation hsa00140
In Vitro Model MCF-10A-neoT cells Breast Homo sapiens (Human) CVCL_5554
In Vivo Model SV40 C3TAg transgenic mouse model Mus musculus
Experiment for
Molecule Alteration		 Clariom D RNA profiling assay
Experiment for
Drug Resistance		 MTT assay; Colony formation assay
Mechanism Description Acquired resistance to fluvastatin is mediated by restorative upregulation of cholesterol biosynthesis pathway genes.
Key Molecule: Decaprenyl diphosphate synthase subunit 1 (PDSS1) [1]
Resistant Disease Breast cancer [ICD-11: 2C60.3]
 Disease Info 
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Differential expression of the molecule in resistant disease
Classification of Disease Breast cancer [ICD-11: 2C60]
The Specified Disease Breast cancer
The Studied Tissue Breast tissue
The Expression Level of Disease Section Compare with the Healthy Individual Tissue
p-value: 6.15E-36
Fold-change: 9.52E-02
Z-score: 1.37E+01
Experimental Note Discovered Using In-vivo Testing Model
Cell Pathway Regulation Steroid biosynthesis signaling pathway Activation hsa00100
Terpenoid bacKbone biosynthesis signaling pathway Activation hsa00900
Steroid hormone biosynthesis signaling pathway Activation hsa00140
In Vitro Model MCF-10A-neoT cells Breast Homo sapiens (Human) CVCL_5554
In Vivo Model SV40 C3TAg transgenic mouse model Mus musculus
Experiment for
Molecule Alteration		 Clariom D RNA profiling assay
Experiment for
Drug Resistance		 MTT assay; Colony formation assay
Mechanism Description Acquired resistance to fluvastatin is mediated by restorative upregulation of cholesterol biosynthesis pathway genes.
Key Molecule: EBP cholestenol delta-isomerase (EBP) [1]
Resistant Disease Breast cancer [ICD-11: 2C60.3]
 Disease Info 
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Differential expression of the molecule in resistant disease
Classification of Disease Breast cancer [ICD-11: 2C60]
The Specified Disease Breast cancer
The Studied Tissue Breast tissue
The Expression Level of Disease Section Compare with the Healthy Individual Tissue
p-value: 8.96E-30
Fold-change: 7.72E-02
Z-score: 1.22E+01
Experimental Note Discovered Using In-vivo Testing Model
Cell Pathway Regulation Steroid biosynthesis signaling pathway Activation hsa00100
Terpenoid bacKbone biosynthesis signaling pathway Activation hsa00900
Steroid hormone biosynthesis signaling pathway Activation hsa00140
In Vitro Model MCF-10A-neoT cells Breast Homo sapiens (Human) CVCL_5554
In Vivo Model SV40 C3TAg transgenic mouse model Mus musculus
Experiment for
Molecule Alteration		 Clariom D RNA profiling assay
Experiment for
Drug Resistance		 MTT assay; Colony formation assay
Mechanism Description Acquired resistance to fluvastatin is mediated by restorative upregulation of cholesterol biosynthesis pathway genes.
Key Molecule: 24-dehydrocholesterol reductase (DHCR24) [1]
Resistant Disease Breast cancer [ICD-11: 2C60.3]
 Disease Info 
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Differential expression of the molecule in resistant disease
Classification of Disease Breast cancer [ICD-11: 2C60]
The Specified Disease Breast cancer
The Studied Tissue Breast tissue
The Expression Level of Disease Section Compare with the Healthy Individual Tissue
p-value: 2.03E-22
Fold-change: 7.58E-02
Z-score: 1.02E+01
Experimental Note Discovered Using In-vivo Testing Model
Cell Pathway Regulation Steroid biosynthesis signaling pathway Activation hsa00100
Terpenoid bacKbone biosynthesis signaling pathway Activation hsa00900
Steroid hormone biosynthesis signaling pathway Activation hsa00140
In Vitro Model MCF-10A-neoT cells Breast Homo sapiens (Human) CVCL_5554
In Vivo Model SV40 C3TAg transgenic mouse model Mus musculus
Experiment for
Molecule Alteration		 Clariom D RNA profiling assay
Experiment for
Drug Resistance		 MTT assay; Colony formation assay
Mechanism Description Acquired resistance to fluvastatin is mediated by restorative upregulation of cholesterol biosynthesis pathway genes.
Key Molecule: Acetyl-CoA acetyltransferase 2 (ACAT2) [1]
Resistant Disease Breast cancer [ICD-11: 2C60.3]
 Disease Info 
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Differential expression of the molecule in resistant disease
Classification of Disease Breast cancer [ICD-11: 2C60]
The Specified Disease Breast cancer
The Studied Tissue Breast tissue
The Expression Level of Disease Section Compare with the Healthy Individual Tissue
p-value: 1.27E-28
Fold-change: 7.52E-02
Z-score: 1.18E+01
Experimental Note Discovered Using In-vivo Testing Model
Cell Pathway Regulation Steroid biosynthesis signaling pathway Activation hsa00100
Terpenoid bacKbone biosynthesis signaling pathway Activation hsa00900
Steroid hormone biosynthesis signaling pathway Activation hsa00140
In Vitro Model MCF-10A-neoT cells Breast Homo sapiens (Human) CVCL_5554
In Vivo Model SV40 C3TAg transgenic mouse model Mus musculus
Experiment for
Molecule Alteration		 Clariom D RNA profiling assay
Experiment for
Drug Resistance		 MTT assay; Colony formation assay
Mechanism Description Acquired resistance to fluvastatin is mediated by restorative upregulation of cholesterol biosynthesis pathway genes.
Key Molecule: Phosphomevalonate kinase (PMVK) [1]
Resistant Disease Breast cancer [ICD-11: 2C60.3]
 Disease Info 
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Differential expression of the molecule in resistant disease
Classification of Disease Breast cancer [ICD-11: 2C60]
The Specified Disease Breast cancer
The Studied Tissue Breast tissue
The Expression Level of Disease Section Compare with the Healthy Individual Tissue
p-value: 8.80E-34
Fold-change: 5.71E-02
Z-score: 1.29E+01
Experimental Note Discovered Using In-vivo Testing Model
Cell Pathway Regulation Steroid biosynthesis signaling pathway Activation hsa00100
Terpenoid bacKbone biosynthesis signaling pathway Activation hsa00900
Steroid hormone biosynthesis signaling pathway Activation hsa00140
In Vitro Model MCF-10A-neoT cells Breast Homo sapiens (Human) CVCL_5554
In Vivo Model SV40 C3TAg transgenic mouse model Mus musculus
Experiment for
Molecule Alteration		 Clariom D RNA profiling assay
Experiment for
Drug Resistance		 MTT assay; Colony formation assay
Mechanism Description Acquired resistance to fluvastatin is mediated by restorative upregulation of cholesterol biosynthesis pathway genes.
Key Molecule: Isopentenyl-diphosphate delta isomerase 1 (IDI1) [1]
Resistant Disease Breast cancer [ICD-11: 2C60.3]
 Disease Info 
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Differential expression of the molecule in resistant disease
Classification of Disease Breast cancer [ICD-11: 2C60]
The Specified Disease Breast cancer
The Studied Tissue Breast tissue
The Expression Level of Disease Section Compare with the Healthy Individual Tissue
p-value: 4.53E-23
Fold-change: 5.53E-02
Z-score: 1.06E+01
Experimental Note Discovered Using In-vivo Testing Model
Cell Pathway Regulation Steroid biosynthesis signaling pathway Activation hsa00100
Terpenoid bacKbone biosynthesis signaling pathway Activation hsa00900
Steroid hormone biosynthesis signaling pathway Activation hsa00140
In Vitro Model MCF-10A-neoT cells Breast Homo sapiens (Human) CVCL_5554
In Vivo Model SV40 C3TAg transgenic mouse model Mus musculus
Experiment for
Molecule Alteration		 Clariom D RNA profiling assay
Experiment for
Drug Resistance		 MTT assay; Colony formation assay
Mechanism Description Acquired resistance to fluvastatin is mediated by restorative upregulation of cholesterol biosynthesis pathway genes.
Key Molecule: Squalene epoxidase (SQLE) [1]
Resistant Disease Breast cancer [ICD-11: 2C60.3]
 Disease Info 
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Differential expression of the molecule in resistant disease
Classification of Disease Breast cancer [ICD-11: 2C60]
The Specified Disease Breast cancer
The Studied Tissue Breast tissue
The Expression Level of Disease Section Compare with the Healthy Individual Tissue
p-value: 9.09E-160
Fold-change: 3.12E-01
Z-score: 3.56E+01
Experimental Note Discovered Using In-vivo Testing Model
Cell Pathway Regulation Steroid biosynthesis signaling pathway Activation hsa00100
Terpenoid bacKbone biosynthesis signaling pathway Activation hsa00900
Steroid hormone biosynthesis signaling pathway Activation hsa00140
In Vitro Model MCF-10A-neoT cells Breast Homo sapiens (Human) CVCL_5554
In Vivo Model SV40 C3TAg transgenic mouse model Mus musculus
Experiment for
Molecule Alteration		 Clariom D RNA profiling assay
Experiment for
Drug Resistance		 MTT assay; Colony formation assay
Mechanism Description Acquired resistance to fluvastatin is mediated by restorative upregulation of cholesterol biosynthesis pathway genes.
Key Molecule: Insulin induced gene 1 (INSIG1) [1]
Resistant Disease Breast cancer [ICD-11: 2C60.3]
 Disease Info 
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Differential expression of the molecule in resistant disease
Classification of Disease Breast cancer [ICD-11: 2C60]
The Specified Disease Breast cancer
The Studied Tissue Breast tissue
The Expression Level of Disease Section Compare with the Healthy Individual Tissue
p-value: 4.46E-03
Fold-change: 2.88E-02
Z-score: 2.86E+00
Experimental Note Discovered Using In-vivo Testing Model
Cell Pathway Regulation Steroid biosynthesis signaling pathway Activation hsa00100
Terpenoid bacKbone biosynthesis signaling pathway Activation hsa00900
Steroid hormone biosynthesis signaling pathway Activation hsa00140
In Vitro Model MCF-10A-neoT cells Breast Homo sapiens (Human) CVCL_5554
In Vivo Model SV40 C3TAg transgenic mouse model Mus musculus
Experiment for
Molecule Alteration		 Clariom D RNA profiling assay
Experiment for
Drug Resistance		 MTT assay; Colony formation assay
Mechanism Description Acquired resistance to fluvastatin is mediated by restorative upregulation of cholesterol biosynthesis pathway genes.
Key Molecule: 3-hydroxy-3-methylglutaryl-CoA synthase 1 (HMGCS1) [1]
Resistant Disease Breast cancer [ICD-11: 2C60.3]
 Disease Info 
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Differential expression of the molecule in resistant disease
Classification of Disease Breast cancer [ICD-11: 2C60]
The Specified Disease Breast cancer
The Studied Tissue Breast tissue
The Expression Level of Disease Section Compare with the Healthy Individual Tissue
p-value: 7.80E-67
Fold-change: 1.62E-01
Z-score: 2.01E+01
Experimental Note Discovered Using In-vivo Testing Model
Cell Pathway Regulation Steroid biosynthesis signaling pathway Activation hsa00100
Terpenoid bacKbone biosynthesis signaling pathway Activation hsa00900
Steroid hormone biosynthesis signaling pathway Activation hsa00140
In Vitro Model MCF-10A-neoT cells Breast Homo sapiens (Human) CVCL_5554
In Vivo Model SV40 C3TAg transgenic mouse model Mus musculus
Experiment for
Molecule Alteration		 Clariom D RNA profiling assay
Experiment for
Drug Resistance		 MTT assay; Colony formation assay
Mechanism Description Acquired resistance to fluvastatin is mediated by restorative upregulation of cholesterol biosynthesis pathway genes.
Key Molecule: Sterol O-acyltransferase 1 (SOAT1) [1]
Resistant Disease Breast cancer [ICD-11: 2C60.3]
 Disease Info 
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Differential expression of the molecule in resistant disease
Classification of Disease Breast cancer [ICD-11: 2C60]
The Specified Disease Breast cancer
The Studied Tissue Breast tissue
The Expression Level of Disease Section Compare with the Healthy Individual Tissue
p-value: 2.41E-33
Fold-change: 1.47E-01
Z-score: 1.31E+01
Experimental Note Discovered Using In-vivo Testing Model
Cell Pathway Regulation Steroid biosynthesis signaling pathway Activation hsa00100
Terpenoid bacKbone biosynthesis signaling pathway Activation hsa00900
Steroid hormone biosynthesis signaling pathway Activation hsa00140
In Vitro Model MCF-10A-neoT cells Breast Homo sapiens (Human) CVCL_5554
In Vivo Model SV40 C3TAg transgenic mouse model Mus musculus
Experiment for
Molecule Alteration		 Clariom D RNA profiling assay
Experiment for
Drug Resistance		 MTT assay; Colony formation assay
Mechanism Description Acquired resistance to fluvastatin is mediated by restorative upregulation of cholesterol biosynthesis pathway genes.
Key Molecule: Geranylgeranyl diphosphate synthase 1 (GGPS1) [1]
Resistant Disease Breast cancer [ICD-11: 2C60.3]
 Disease Info 
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Differential expression of the molecule in resistant disease
Classification of Disease Breast cancer [ICD-11: 2C60]
The Specified Disease Breast cancer
The Studied Tissue Breast tissue
The Expression Level of Disease Section Compare with the Healthy Individual Tissue
p-value: 6.77E-55
Fold-change: 1.07E-01
Z-score: 1.81E+01
Experimental Note Discovered Using In-vivo Testing Model
Cell Pathway Regulation Steroid biosynthesis signaling pathway Activation hsa00100
Terpenoid bacKbone biosynthesis signaling pathway Activation hsa00900
Steroid hormone biosynthesis signaling pathway Activation hsa00140
In Vitro Model MCF-10A-neoT cells Breast Homo sapiens (Human) CVCL_5554
In Vivo Model SV40 C3TAg transgenic mouse model Mus musculus
Experiment for
Molecule Alteration		 Clariom D RNA profiling assay
Experiment for
Drug Resistance		 MTT assay; Colony formation assay
Mechanism Description Acquired resistance to fluvastatin is mediated by restorative upregulation of cholesterol biosynthesis pathway genes.
Key Molecule: 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) [1]
Resistant Disease Breast cancer [ICD-11: 2C60.3]
 Disease Info 
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Differential expression of the molecule in resistant disease
Classification of Disease Breast cancer [ICD-11: 2C60]
The Specified Disease Breast cancer
The Studied Tissue Breast tissue
The Expression Level of Disease Section Compare with the Healthy Individual Tissue
p-value: 5.11E-15
Fold-change: 1.01E-01
Z-score: 8.22E+00
Experimental Note Discovered Using In-vivo Testing Model
Cell Pathway Regulation Steroid biosynthesis signaling pathway Activation hsa00100
Terpenoid bacKbone biosynthesis signaling pathway Activation hsa00900
Steroid hormone biosynthesis signaling pathway Activation hsa00140
In Vitro Model MCF-10A-neoT cells Breast Homo sapiens (Human) CVCL_5554
In Vivo Model SV40 C3TAg transgenic mouse model Mus musculus
Experiment for
Molecule Alteration		 Clariom D RNA profiling assay
Experiment for
Drug Resistance		 MTT assay; Colony formation assay
Mechanism Description Acquired resistance to fluvastatin is mediated by restorative upregulation of cholesterol biosynthesis pathway genes.
Key Molecule: Dehydrodolichyl diphosphate synthase subunit (DHDDS) [1]
Resistant Disease Breast cancer [ICD-11: 2C60.3]
 Disease Info 
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Experimental Note Discovered Using In-vivo Testing Model
Cell Pathway Regulation Steroid biosynthesis signaling pathway Activation hsa00100
Terpenoid bacKbone biosynthesis signaling pathway Activation hsa00900
Steroid hormone biosynthesis signaling pathway Activation hsa00140
In Vitro Model MCF-10A-neoT cells Breast Homo sapiens (Human) CVCL_5554
In Vivo Model SV40 C3TAg transgenic mouse model Mus musculus
Experiment for
Molecule Alteration		 Clariom D RNA profiling assay
Experiment for
Drug Resistance		 MTT assay; Colony formation assay
Mechanism Description Acquired resistance to fluvastatin is mediated by restorative upregulation of cholesterol biosynthesis pathway genes.
Key Molecule: HSA17B7 (HSA17B7) [1]
Resistant Disease Breast cancer [ICD-11: 2C60.3]
 Disease Info 
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Experimental Note Discovered Using In-vivo Testing Model
Cell Pathway Regulation Steroid biosynthesis signaling pathway Activation hsa00100
Terpenoid bacKbone biosynthesis signaling pathway Activation hsa00900
Steroid hormone biosynthesis signaling pathway Activation hsa00140
In Vitro Model MCF-10A-neoT cells Breast Homo sapiens (Human) CVCL_5554
In Vivo Model SV40 C3TAg transgenic mouse model Mus musculus
Experiment for
Molecule Alteration		 Clariom D RNA profiling assay
Experiment for
Drug Resistance		 MTT assay; Colony formation assay
Mechanism Description Acquired resistance to fluvastatin is mediated by restorative upregulation of cholesterol biosynthesis pathway genes.
Key Molecule: Lanosterol synthase (LSS) [1]
Resistant Disease Breast cancer [ICD-11: 2C60.3]
 Disease Info 
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Experimental Note Discovered Using In-vivo Testing Model
Cell Pathway Regulation Steroid biosynthesis signaling pathway Activation hsa00100
Terpenoid bacKbone biosynthesis signaling pathway Activation hsa00900
Steroid hormone biosynthesis signaling pathway Activation hsa00140
In Vitro Model MCF-10A-neoT cells Breast Homo sapiens (Human) CVCL_5554
In Vivo Model SV40 C3TAg transgenic mouse model Mus musculus
Experiment for
Molecule Alteration		 Clariom D RNA profiling assay
Experiment for
Drug Resistance		 MTT assay; Colony formation assay
Mechanism Description Acquired resistance to fluvastatin is mediated by restorative upregulation of cholesterol biosynthesis pathway genes.
Key Molecule: NSDH1 (NSDH1) [1]
Resistant Disease Breast cancer [ICD-11: 2C60.3]
 Disease Info 
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Experimental Note Discovered Using In-vivo Testing Model
Cell Pathway Regulation Steroid biosynthesis signaling pathway Activation hsa00100
Terpenoid bacKbone biosynthesis signaling pathway Activation hsa00900
Steroid hormone biosynthesis signaling pathway Activation hsa00140
In Vitro Model MCF-10A-neoT cells Breast Homo sapiens (Human) CVCL_5554
In Vivo Model SV40 C3TAg transgenic mouse model Mus musculus
Experiment for
Molecule Alteration		 Clariom D RNA profiling assay
Experiment for
Drug Resistance		 MTT assay; Colony formation assay
Mechanism Description Acquired resistance to fluvastatin is mediated by restorative upregulation of cholesterol biosynthesis pathway genes.
Key Molecule: Transmembrane 7 superfamily member 2 (TM7SF2) [1]
Resistant Disease Breast cancer [ICD-11: 2C60.3]
 Disease Info 
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Experimental Note Discovered Using In-vivo Testing Model
Cell Pathway Regulation Steroid biosynthesis signaling pathway Activation hsa00100
Terpenoid bacKbone biosynthesis signaling pathway Activation hsa00900
Steroid hormone biosynthesis signaling pathway Activation hsa00140
In Vitro Model MCF-10A-neoT cells Breast Homo sapiens (Human) CVCL_5554
In Vivo Model SV40 C3TAg transgenic mouse model Mus musculus
Experiment for
Molecule Alteration		 Clariom D RNA profiling assay
Experiment for
Drug Resistance		 MTT assay; Colony formation assay
Mechanism Description Acquired resistance to fluvastatin is mediated by restorative upregulation of cholesterol biosynthesis pathway genes.
  Drug Inactivation by Structure Modification (DISM) Click to Show/Hide
Key Molecule: Cytochrome P450 family 51 subfamily A member 1 (CYP51A1) [1]
Resistant Disease Breast cancer [ICD-11: 2C60.3]
 Disease Info 
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Experimental Note Discovered Using In-vivo Testing Model
Cell Pathway Regulation Steroid biosynthesis signaling pathway Activation hsa00100
Terpenoid bacKbone biosynthesis signaling pathway Activation hsa00900
Steroid hormone biosynthesis signaling pathway Activation hsa00140
In Vitro Model MCF-10A-neoT cells Breast Homo sapiens (Human) CVCL_5554
In Vivo Model SV40 C3TAg transgenic mouse model Mus musculus
Experiment for
Molecule Alteration		 Clariom D RNA profiling assay
Experiment for
Drug Resistance		 MTT assay; Colony formation assay
Mechanism Description Acquired resistance to fluvastatin is mediated by restorative upregulation of cholesterol biosynthesis pathway genes.
References
Ref 1 Gene signature associated with resistance to fluvastatin chemoprevention for breast cancer .BMC Cancer. 2022 Mar 17;22(1):282. doi: 10.1186/s12885-022-09353-2. 10.1186/s12885-022-09353-2

If you find any error in data or bug in web service, please kindly report it to Dr. Sun and Dr. Yu.