Molecule Information
General Information of the Molecule (ID: Mol01893)
| Name |
Lanosterol synthase (LSS)
,Homo sapiens
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| Synonyms |
LSS; OSC
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| Molecule Type |
Protein
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| Gene Name |
LSS
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| Gene ID | |||||
| Location |
chr21:46,188,141-46,228,824[-]
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| Sequence |
MTEGTCLRRRGGPYKTEPATDLGRWRLNCERGRQTWTYLQDERAGREQTGLEAYALGLDT
KNYFKDLPKAHTAFEGALNGMTFYVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLP AGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVSLRILGVGPDDPDLVRARNIL HKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQVYLPM SYCYAVRLSAAEDPLVQSLRQELYVEDFASIDWLAQRNNVAPDELYTPHSWLLRVVYALL NLYEHHHSAHLRQRAVQKLYEHIVADDRFTKSISIGPISKTINMLVRWYVDGPASTAFQE HVSRIPDYLWMGLDGMKMQGTNGSQIWDTAFAIQALLEAGGHHRPEFSSCLQKAHEFLRL SQVPDNPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLLQEKCPHVTEHIPR ERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQA LKYFHKRFPEHRAAEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMG QTYRDGTACAEVSRACDFLLSRQMADGGWGEDFESCEERRYLQSAQSQIHNTCWAMMGLM AVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSCAISYTSYRNIFPIWALGRFS QLYPERALAGHP Click to Show/Hide
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| 3D-structure |
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| Function |
Key enzyme in the cholesterol biosynthesis pathway. Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency.
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| Uniprot ID | |||||
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Type(s) of Resistant Mechanism of This Molecule
UAPP: Unusual Activation of Pro-survival Pathway
Drug Resistance Data Categorized by Drug
Approved Drug(s)
1 drug(s) in total
Fluvastatin
| Drug Resistance Data Categorized by Their Corresponding Mechanisms | ||||
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Unusual Activation of Pro-survival Pathway (UAPP)
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| Disease Class: Breast cancer [ICD-11: 2C60.3] | [1] | |||
| Resistant Disease | Breast cancer [ICD-11: 2C60.3] | |||
| Resistant Drug | Fluvastatin | |||
| Molecule Alteration | Expression | Up-regulation |
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| Experimental Note | Discovered Using In-vivo Testing Model | |||
| Cell Pathway Regulation | Steroid biosynthesis signaling pathway | Activation | hsa00100 | |
| Terpenoid bacKbone biosynthesis signaling pathway | Activation | hsa00900 | ||
| Steroid hormone biosynthesis signaling pathway | Activation | hsa00140 | ||
| In Vitro Model | MCF-10A-neoT cells | Breast | Homo sapiens (Human) | CVCL_5554 |
| In Vivo Model | SV40 C3TAg transgenic mouse model | Mus musculus | ||
| Experiment for Molecule Alteration |
Clariom D RNA profiling assay | |||
| Experiment for Drug Resistance |
MTT assay; Colony formation assay | |||
| Mechanism Description | Acquired resistance to fluvastatin is mediated by restorative upregulation of cholesterol biosynthesis pathway genes. | |||
Disease- and Tissue-specific Abundances of This Molecule
ICD Disease Classification 02
Breast cancer [ICD-11: 2C60]
| Differential expression of molecule in resistant diseases | ||
| The Studied Tissue | Breast tissue | |
| The Specified Disease | Breast cancer | |
| The Expression Level of Disease Section Compare with the Healthy Individual Tissue | p-value: 1.16E-06; Fold-change: -3.27E-01; Z-score: -5.91E-01 | |
| The Expression Level of Disease Section Compare with the Adjacent Tissue | p-value: 1.72E-01; Fold-change: -8.89E-02; Z-score: -2.22E-01 | |
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Molecule expression in the normal tissue adjacent to the diseased tissue of patients
Molecule expression in the diseased tissue of patients
Molecule expression in the normal tissue of healthy individuals
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| Disease-specific Molecule Abundances |
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Click to View the Clearer Original Diagram |
Tissue-specific Molecule Abundances in Healthy Individuals
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References
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