Disease Information

General Information of the Disease (ID: DIS00192)
Name
Acute lymphoblastic leukaemia
ICD
ICD-11: 2A70
Resistance Map
Type(s) of Resistant Mechanism of This Disease
  UAPP: Unusual Activation of Pro-survival Pathway
Drug Resistance Data Categorized by Drug
Approved Drug(s)
1 drug(s) in total
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Doxorubicin
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
  Unusual Activation of Pro-survival Pathway (UAPP) Click to Show/Hide
Key Molecule: Bromodomain containing 2 (BRD2) [1]
Resistant Disease Lymphoblastic lymphoma [ICD-11: 2A70.0]
Resistant Drug Doxorubicin
 Drug Info 
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Experimental Note Identified from the Human Clinical Data
Cell Pathway Regulation RasGRP1/Ras/ERK signaling pathway Activation hsa04010
Cell apoptosis Inhibition hsa04210
In Vitro Model Jurkat cells Pleural effusion Homo sapiens (Human) CVCL_0065
SUP-T1 cells Pleural effusion Homo sapiens (Human) CVCL_1714
MEK-293 cells Blood vessel Homo sapiens (Human) N.A.
In Vivo Model BALB/C-nu/nu athymic nude mice model Mus musculus
Experiment for
Molecule Alteration		 sqRT-PCR; Western blot analysis
Experiment for
Drug Resistance		 MTT assay; Flow cytometry assay
Mechanism Description The expression of BRD2 was upregulated in drug-resistant adult T-LBL samples. Functional studies of BRD2 further demonstrated the critical role of BRD2. BRD2 induces drug resistance of T-LBL by activating the MEK/ERK/c-Myc signaling pathway.
Key Molecule: Bromodomain containing 2 (BRD2) [1]
Resistant Disease Lymphoblastic lymphoma [ICD-11: 2A70.0]
Resistant Drug Doxorubicin
 Drug Info 
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Experimental Note Identified from the Human Clinical Data
Cell Pathway Regulation RasGRP1/Ras/ERK signaling pathway Activation hsa04010
Cell apoptosis Inhibition hsa04210
In Vitro Model Jurkat cells Pleural effusion Homo sapiens (Human) CVCL_0065
SUP-T1 cells Pleural effusion Homo sapiens (Human) CVCL_1714
MEK-293 cells Blood vessel Homo sapiens (Human) N.A.
In Vivo Model BALB/C-nu/nu athymic nude mice model Mus musculus
Experiment for
Molecule Alteration		 sqRT-PCR; Western blot analysis
Experiment for
Drug Resistance		 MTT assay; Flow cytometry assay
Mechanism Description The expression of BRD2 was upregulated in drug-resistant adult T-LBL samples. Functional studies of BRD2 further demonstrated the critical role of BRD2. BRD2 induces drug resistance of T-LBL by activating the MEK/ERK/c-Myc signaling pathway.
References
Ref 1 BRD2 induces drug resistance through activation of the RasGRP1/Ras/ERK signaling pathway in adult T-cell lymphoblastic lymphoma .Cancer Commun (Lond). 2020 Jun;40(6):245-259. doi: 10.1002/cac2.12039. Epub 2020 May 27. 10.1002/cac2.12039

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