Molecule Information

General Information of the Molecule (ID: Mol01913)
Name
Bromodomain containing 2 (BRD2) ,Homo sapiens
Synonyms
BRD2; KIAA9001; RING3
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Molecule Type
Protein
Gene Name
BRD2
Gene ID
6046
Location
chr6:32,968,594-32,981,505[+]
Sequence
MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPAN
PPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQP
MDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASM
PQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLNI
PHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPA
SPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKEL
LSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRL
MFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSES
SSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQG
PISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAAL
GPSGFGPSGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGE
KLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKP
VGKTKEELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSS
SDSSSSSSSSSSSDTSDSDSG
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3D-structure
PDB ID
4UYG
Classification
Transcription
Method
X-ray diffraction
Resolution
2.50  Å
Function
May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.
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Uniprot ID
BRD2_HUMAN
Ensembl ID
ENSG00000204256
HGNC ID
HGNC:1103
        Click to Show/Hide the Complete Species Lineage
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Type(s) of Resistant Mechanism of This Molecule
  UAPP: Unusual Activation of Pro-survival Pathway
Drug Resistance Data Categorized by Drug
Approved Drug(s)
1 drug(s) in total
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Doxorubicin
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
  Unusual Activation of Pro-survival Pathway (UAPP) Click to Show/Hide
Disease Class: Lymphoblastic lymphoma [ICD-11: 2A70.0] [1]
Resistant Disease Lymphoblastic lymphoma [ICD-11: 2A70.0]
 Disease Info 
Resistant Drug Doxorubicin
 Drug Info 
Molecule Alteration Expression
Up-regulation
Experimental Note Identified from the Human Clinical Data
Cell Pathway Regulation RasGRP1/Ras/ERK signaling pathway Activation hsa04010
Cell apoptosis Inhibition hsa04210
In Vitro Model Jurkat cells Pleural effusion Homo sapiens (Human) CVCL_0065
SUP-T1 cells Pleural effusion Homo sapiens (Human) CVCL_1714
MEK-293 cells Blood vessel Homo sapiens (Human) N.A.
In Vivo Model BALB/C-nu/nu athymic nude mice model Mus musculus
Experiment for
Molecule Alteration		 sqRT-PCR; Western blot analysis
Experiment for
Drug Resistance		 MTT assay; Flow cytometry assay
Mechanism Description The expression of BRD2 was upregulated in drug-resistant adult T-LBL samples. Functional studies of BRD2 further demonstrated the critical role of BRD2. BRD2 induces drug resistance of T-LBL by activating the MEK/ERK/c-Myc signaling pathway.
Disease Class: Lymphoblastic lymphoma [ICD-11: 2A70.0] [1]
Resistant Disease Lymphoblastic lymphoma [ICD-11: 2A70.0]
 Disease Info 
Resistant Drug Doxorubicin
 Drug Info 
Molecule Alteration Expression
Up-regulation
Experimental Note Identified from the Human Clinical Data
Cell Pathway Regulation RasGRP1/Ras/ERK signaling pathway Activation hsa04010
Cell apoptosis Inhibition hsa04210
In Vitro Model Jurkat cells Pleural effusion Homo sapiens (Human) CVCL_0065
SUP-T1 cells Pleural effusion Homo sapiens (Human) CVCL_1714
MEK-293 cells Blood vessel Homo sapiens (Human) N.A.
In Vivo Model BALB/C-nu/nu athymic nude mice model Mus musculus
Experiment for
Molecule Alteration		 sqRT-PCR; Western blot analysis
Experiment for
Drug Resistance		 MTT assay; Flow cytometry assay
Mechanism Description The expression of BRD2 was upregulated in drug-resistant adult T-LBL samples. Functional studies of BRD2 further demonstrated the critical role of BRD2. BRD2 induces drug resistance of T-LBL by activating the MEK/ERK/c-Myc signaling pathway.
References
Ref 1 BRD2 induces drug resistance through activation of the RasGRP1/Ras/ERK signaling pathway in adult T-cell lymphoblastic lymphoma .Cancer Commun (Lond). 2020 Jun;40(6):245-259. doi: 10.1002/cac2.12039. Epub 2020 May 27. 10.1002/cac2.12039

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