Disease Information

General Information of the Disease (ID: DIS00142)
Name
Surgical wound infection
ICD
ICD-11: NE81
Resistance Map
Type(s) of Resistant Mechanism of This Disease
  ADTT: Aberration of the Drug's Therapeutic Target
  IDUE: Irregularity in Drug Uptake and Drug Efflux
Drug Resistance Data Categorized by Drug
Approved Drug(s)
11 drug(s) in total
Click to Show/Hide the Full List of Drugs
Chloramphenicol
Click to Show/Hide
Drug Resistance Data Categorized by Their Corresponding Mechanisms
  Irregularity in Drug Uptake and Drug Efflux (IDUE) Click to Show/Hide
Key Molecule: Lincomycin resistance efflux pump (LMRS) [1]
Resistant Disease Staphylococcus aureus infection [ICD-11: 1B54.0]
Resistant Drug Chloramphenicol
 Drug Info 
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Experimental Note Identified from the Human Clinical Data
In Vitro Model Escherichia coli kAM32 562
Staphylococcus aureus OM505 1280
Experiment for
Molecule Alteration		 Whole genome sequence assay; Allelic frequency measurement assay
Experiment for
Drug Resistance		 Broth microdilution method assay
Mechanism Description LmrS is a multidrug efflux pump of the major facilitator superfamily from staphylococcus aureus.
Clarithromycin
Click to Show/Hide
Drug Resistance Data Categorized by Their Corresponding Mechanisms
  Aberration of the Drug's Therapeutic Target (ADTT) Click to Show/Hide
Key Molecule: Erythromycin resistance protein (ERM38) [2]
Resistant Disease Mycobacterium smegmatis infection [ICD-11: 1B2Z.3]
Resistant Drug Clarithromycin
 Drug Info 
Molecule Alteration Expression
Inherence
 Molecule Info 
Experimental Note Identified from the Human Clinical Data
In Vitro Model Mycobacterium smegmatis mc2155 246196
Mycobacterium smegmatis mc2155/pMIP12 246196
Mycobacterium smegmatis mc2155/pOMV20 246196
Mycobacterium smegmatis mc2155/pOMV30 246196
Experiment for
Molecule Alteration		 MALDI mass spectrometry assay
Experiment for
Drug Resistance		 MIC assay
Mechanism Description Erm (38) is a specific dimethyltransferase. The strain obtained drug resistance by adding two methyl groups to A2058 in Mycobacterium 23SrRNA.
Key Molecule: Erythromycin resistance protein (ERM38) [2]
Resistant Disease Mycobacterium smegmatis infection [ICD-11: 1B2Z.3]
Resistant Drug Clarithromycin
 Drug Info 
Molecule Alteration Expression
Inherence
 Molecule Info 
Experimental Note Identified from the Human Clinical Data
In Vitro Model Mycobacterium smegmatis mc2155 246196
Mycobacterium smegmatis mc2155/pMIP12 246196
Mycobacterium smegmatis mc2155/pOMV20 246196
Mycobacterium smegmatis mc2155/pOMV30 246196
Experiment for
Molecule Alteration		 MALDI mass spectrometry assay
Experiment for
Drug Resistance		 MIC assay
Mechanism Description Erm (38) is a specific dimethyltransferase. The strain obtained drug resistance by adding two methyl groups to A2058 in Mycobacterium 23SrRNA.
Clindamycin
Click to Show/Hide
Drug Resistance Data Categorized by Their Corresponding Mechanisms
  Aberration of the Drug's Therapeutic Target (ADTT) Click to Show/Hide
Key Molecule: Erythromycin resistance protein (ERM38) [2]
Resistant Disease Mycobacterium smegmatis infection [ICD-11: 1B2Z.3]
Resistant Drug Clindamycin
 Drug Info 
Molecule Alteration Expression
Inherence
 Molecule Info 
Experimental Note Identified from the Human Clinical Data
In Vitro Model Mycobacterium smegmatis mc2155 246196
Mycobacterium smegmatis mc2155/pMIP12 246196
Mycobacterium smegmatis mc2155/pOMV20 246196
Mycobacterium smegmatis mc2155/pOMV30 246196
Experiment for
Molecule Alteration		 MALDI mass spectrometry assay
Experiment for
Drug Resistance		 MIC assay
Mechanism Description Erm (38) is a specific dimethyltransferase. The strain obtained drug resistance by adding two methyl groups to A2058 in Mycobacterium 23SrRNA.
Key Molecule: Erythromycin resistance protein (ERM38) [2]
Resistant Disease Mycobacterium smegmatis infection [ICD-11: 1B2Z.3]
Resistant Drug Clindamycin
 Drug Info 
Molecule Alteration Expression
Inherence
 Molecule Info 
Experimental Note Identified from the Human Clinical Data
In Vitro Model Mycobacterium smegmatis mc2155 246196
Mycobacterium smegmatis mc2155/pMIP12 246196
Mycobacterium smegmatis mc2155/pOMV20 246196
Mycobacterium smegmatis mc2155/pOMV30 246196
Experiment for
Molecule Alteration		 MALDI mass spectrometry assay
Experiment for
Drug Resistance		 MIC assay
Mechanism Description Erm (38) is a specific dimethyltransferase. The strain obtained drug resistance by adding two methyl groups to A2058 in Mycobacterium 23SrRNA.
Erythromycin
Click to Show/Hide
Drug Resistance Data Categorized by Their Corresponding Mechanisms
  Aberration of the Drug's Therapeutic Target (ADTT) Click to Show/Hide
Key Molecule: Erythromycin resistance protein (ERM38) [2]
Resistant Disease Mycobacterium smegmatis infection [ICD-11: 1B2Z.3]
Resistant Drug Erythromycin
 Drug Info 
Molecule Alteration Expression
Inherence
 Molecule Info 
Experimental Note Identified from the Human Clinical Data
In Vitro Model Mycobacterium smegmatis mc2155 246196
Mycobacterium smegmatis mc2155/pMIP12 246196
Mycobacterium smegmatis mc2155/pOMV20 246196
Mycobacterium smegmatis mc2155/pOMV30 246196
Experiment for
Molecule Alteration		 MALDI mass spectrometry assay
Experiment for
Drug Resistance		 MIC assay
Mechanism Description Erm (38) is a specific dimethyltransferase. The strain obtained drug resistance by adding two methyl groups to A2058 in Mycobacterium 23SrRNA.
Key Molecule: Erythromycin resistance protein (ERM38) [2]
Resistant Disease Mycobacterium smegmatis infection [ICD-11: 1B2Z.3]
Resistant Drug Erythromycin
 Drug Info 
Molecule Alteration Expression
Inherence
 Molecule Info 
Experimental Note Identified from the Human Clinical Data
In Vitro Model Mycobacterium smegmatis mc2155 246196
Mycobacterium smegmatis mc2155/pMIP12 246196
Mycobacterium smegmatis mc2155/pOMV20 246196
Mycobacterium smegmatis mc2155/pOMV30 246196
Experiment for
Molecule Alteration		 MALDI mass spectrometry assay
Experiment for
Drug Resistance		 MIC assay
Mechanism Description Erm (38) is a specific dimethyltransferase. The strain obtained drug resistance by adding two methyl groups to A2058 in Mycobacterium 23SrRNA.
  Irregularity in Drug Uptake and Drug Efflux (IDUE) Click to Show/Hide
Key Molecule: Lincomycin resistance efflux pump (LMRS) [1]
Resistant Disease Staphylococcus aureus infection [ICD-11: 1B54.0]
Resistant Drug Erythromycin
 Drug Info 
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Experimental Note Identified from the Human Clinical Data
In Vitro Model Escherichia coli kAM32 562
Staphylococcus aureus OM505 1280
Experiment for
Molecule Alteration		 Whole genome sequence assay; Allelic frequency measurement assay
Experiment for
Drug Resistance		 Broth microdilution method assay
Mechanism Description LmrS is a multidrug efflux pump of the major facilitator superfamily from staphylococcus aureus.
Florfenicol
Click to Show/Hide
Drug Resistance Data Categorized by Their Corresponding Mechanisms
  Irregularity in Drug Uptake and Drug Efflux (IDUE) Click to Show/Hide
Key Molecule: Lincomycin resistance efflux pump (LMRS) [1]
Resistant Disease Staphylococcus aureus infection [ICD-11: 1B54.0]
Resistant Drug Florfenicol
 Drug Info 
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Experimental Note Identified from the Human Clinical Data
In Vitro Model Escherichia coli kAM32 562
Staphylococcus aureus OM505 1280
Experiment for
Molecule Alteration		 Whole genome sequence assay; Allelic frequency measurement assay
Experiment for
Drug Resistance		 Broth microdilution method assay
Mechanism Description LmrS is a multidrug efflux pump of the major facilitator superfamily from staphylococcus aureus.
Kanamycin
Click to Show/Hide
Drug Resistance Data Categorized by Their Corresponding Mechanisms
  Irregularity in Drug Uptake and Drug Efflux (IDUE) Click to Show/Hide
Key Molecule: Lincomycin resistance efflux pump (LMRS) [1]
Resistant Disease Staphylococcus aureus infection [ICD-11: 1B54.0]
Resistant Drug Kanamycin
 Drug Info 
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Experimental Note Identified from the Human Clinical Data
In Vitro Model Escherichia coli kAM32 562
Staphylococcus aureus OM505 1280
Experiment for
Molecule Alteration		 Whole genome sequence assay; Allelic frequency measurement assay
Experiment for
Drug Resistance		 Broth microdilution method assay
Mechanism Description LmrS is a multidrug efflux pump of the major facilitator superfamily from staphylococcus aureus.
Linezolid
Click to Show/Hide
Drug Resistance Data Categorized by Their Corresponding Mechanisms
  Irregularity in Drug Uptake and Drug Efflux (IDUE) Click to Show/Hide
Key Molecule: Lincomycin resistance efflux pump (LMRS) [1]
Resistant Disease Staphylococcus aureus infection [ICD-11: 1B54.0]
Resistant Drug Linezolid
 Drug Info 
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Experimental Note Identified from the Human Clinical Data
In Vitro Model Escherichia coli kAM32 562
Staphylococcus aureus OM505 1280
Experiment for
Molecule Alteration		 Whole genome sequence assay; Allelic frequency measurement assay
Experiment for
Drug Resistance		 Broth microdilution method assay
Mechanism Description LmrS is a multidrug efflux pump of the major facilitator superfamily from staphylococcus aureus.
Quinupristin
Click to Show/Hide
Drug Resistance Data Categorized by Their Corresponding Mechanisms
  Aberration of the Drug's Therapeutic Target (ADTT) Click to Show/Hide
Key Molecule: Erythromycin resistance protein (ERM38) [2]
Resistant Disease Mycobacterium smegmatis infection [ICD-11: 1B2Z.3]
Resistant Drug Quinupristin
 Drug Info 
Molecule Alteration Expression
Inherence
 Molecule Info 
Experimental Note Identified from the Human Clinical Data
In Vitro Model Mycobacterium smegmatis mc2155 246196
Mycobacterium smegmatis mc2155/pMIP12 246196
Mycobacterium smegmatis mc2155/pOMV20 246196
Mycobacterium smegmatis mc2155/pOMV30 246196
Experiment for
Molecule Alteration		 MALDI mass spectrometry assay
Experiment for
Drug Resistance		 MIC assay
Mechanism Description Erm (38) is a specific dimethyltransferase. The strain obtained drug resistance by adding two methyl groups to A2058 in Mycobacterium 23SrRNA.
Key Molecule: Erythromycin resistance protein (ERM38) [2]
Resistant Disease Mycobacterium smegmatis infection [ICD-11: 1B2Z.3]
Resistant Drug Quinupristin
 Drug Info 
Molecule Alteration Expression
Inherence
 Molecule Info 
Experimental Note Identified from the Human Clinical Data
In Vitro Model Mycobacterium smegmatis mc2155 246196
Mycobacterium smegmatis mc2155/pMIP12 246196
Mycobacterium smegmatis mc2155/pOMV20 246196
Mycobacterium smegmatis mc2155/pOMV30 246196
Experiment for
Molecule Alteration		 MALDI mass spectrometry assay
Experiment for
Drug Resistance		 MIC assay
Mechanism Description Erm (38) is a specific dimethyltransferase. The strain obtained drug resistance by adding two methyl groups to A2058 in Mycobacterium 23SrRNA.
Streptomycin
Click to Show/Hide
Drug Resistance Data Categorized by Their Corresponding Mechanisms
  Irregularity in Drug Uptake and Drug Efflux (IDUE) Click to Show/Hide
Key Molecule: Lincomycin resistance efflux pump (LMRS) [1]
Resistant Disease Staphylococcus aureus infection [ICD-11: 1B54.0]
Resistant Drug Streptomycin
 Drug Info 
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Experimental Note Identified from the Human Clinical Data
In Vitro Model Escherichia coli kAM32 562
Staphylococcus aureus OM505 1280
Experiment for
Molecule Alteration		 Whole genome sequence assay; Allelic frequency measurement assay
Experiment for
Drug Resistance		 Broth microdilution method assay
Mechanism Description LmrS is a multidrug efflux pump of the major facilitator superfamily from staphylococcus aureus.
Telithromycin
Click to Show/Hide
Drug Resistance Data Categorized by Their Corresponding Mechanisms
  Aberration of the Drug's Therapeutic Target (ADTT) Click to Show/Hide
Key Molecule: Erythromycin resistance protein (ERM38) [2]
Resistant Disease Mycobacterium smegmatis infection [ICD-11: 1B2Z.3]
Resistant Drug Telithromycin
 Drug Info 
Molecule Alteration Expression
Inherence
 Molecule Info 
Experimental Note Identified from the Human Clinical Data
In Vitro Model Mycobacterium smegmatis mc2155 246196
Mycobacterium smegmatis mc2155/pMIP12 246196
Mycobacterium smegmatis mc2155/pOMV20 246196
Mycobacterium smegmatis mc2155/pOMV30 246196
Experiment for
Molecule Alteration		 MALDI mass spectrometry assay
Experiment for
Drug Resistance		 MIC assay
Mechanism Description Erm (38) is a specific dimethyltransferase. The strain obtained drug resistance by adding two methyl groups to A2058 in Mycobacterium 23SrRNA.
Key Molecule: Erythromycin resistance protein (ERM38) [2]
Resistant Disease Mycobacterium smegmatis infection [ICD-11: 1B2Z.3]
Resistant Drug Telithromycin
 Drug Info 
Molecule Alteration Expression
Inherence
 Molecule Info 
Experimental Note Identified from the Human Clinical Data
In Vitro Model Mycobacterium smegmatis mc2155 246196
Mycobacterium smegmatis mc2155/pMIP12 246196
Mycobacterium smegmatis mc2155/pOMV20 246196
Mycobacterium smegmatis mc2155/pOMV30 246196
Experiment for
Molecule Alteration		 MALDI mass spectrometry assay
Experiment for
Drug Resistance		 MIC assay
Mechanism Description Erm (38) is a specific dimethyltransferase. The strain obtained drug resistance by adding two methyl groups to A2058 in Mycobacterium 23SrRNA.
Trimethoprim
Click to Show/Hide
Drug Resistance Data Categorized by Their Corresponding Mechanisms
  Irregularity in Drug Uptake and Drug Efflux (IDUE) Click to Show/Hide
Key Molecule: Lincomycin resistance efflux pump (LMRS) [1]
Resistant Disease Staphylococcus aureus infection [ICD-11: 1B54.0]
Resistant Drug Trimethoprim
 Drug Info 
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Experimental Note Identified from the Human Clinical Data
In Vitro Model Escherichia coli kAM32 562
Staphylococcus aureus OM505 1280
Experiment for
Molecule Alteration		 Whole genome sequence assay; Allelic frequency measurement assay
Experiment for
Drug Resistance		 Broth microdilution method assay
Mechanism Description LmrS is a multidrug efflux pump of the major facilitator superfamily from staphylococcus aureus.
References
Ref 1 LmrS is a multidrug efflux pump of the major facilitator superfamily from Staphylococcus aureus. Antimicrob Agents Chemother. 2010 Dec;54(12):5406-12. doi: 10.1128/AAC.00580-10. Epub 2010 Sep 20.
Ref 2 Mycobacterium smegmatis Erm(38) is a reluctant dimethyltransferase. Antimicrob Agents Chemother. 2005 Sep;49(9):3803-9. doi: 10.1128/AAC.49.9.3803-3809.2005.

If you find any error in data or bug in web service, please kindly report it to Dr. Sun and Dr. Yu.