Molecule Information

General Information of the Molecule (ID: Mol00820)
Name
Beta-lactamase (BLA) ,Acidaminococcus fermentans
Synonyms
FX155_06310
    Click to Show/Hide
Molecule Type
Protein
Gene Name
aci1
Sequence
MKKFCFLFLIICGLMVFCLQDCQARQKLNLADLENKYNAVIGVYAVDMENGKKICYKPDT
RFSYCSTHKVFTAAELLRQKNTSDLNEIRKFSAEDILSYAPITKDHVADGMTLAEICSAS
LRWSDNTAANLILQEIGGVENFKVALKNIGDKTTKPARNEPELNLFNPKDNRDTSTPRQM
VKNLQVYIFGDILSDDKKKLLIDWMSDNSITDTLIKAETPQGWKVIDKSGSGDYGARNDI
AVIYPPNRKPIVMAIMSRRTEKNAKSDDAMIAEAAKRIFDNLVF
    Click to Show/Hide
Uniprot ID
Q9XBM2_ACIFE
        Click to Show/Hide the Complete Species Lineage
Kingdom: N.A.
Phylum: Firmicutes
Class: Negativicutes
Order: Acidaminococcales
Family: Acidaminococcaceae
Genus: Acidaminococcus
Species: Acidaminococcus fermentans
Type(s) of Resistant Mechanism of This Molecule
  DISM: Drug Inactivation by Structure Modification
Drug Resistance Data Categorized by Drug
Approved Drug(s)
5 drug(s) in total
Click to Show/Hide the Full List of Drugs
Amoxicillin
Click to Show/Hide
Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Drug Inactivation by Structure Modification (DISM) Click to Show/Hide
Disease Class: Anaerobic Bacterial infection [1], [2]
Resistant Disease Anaerobic Bacterial infection [ICD-11: 1A00-1A09]
 Disease Info 
Resistant Drug Amoxicillin
 Drug Info 
Molecule Alteration Expression
Up-regulation
Experimental Note Identified from the Human Clinical Data
In Vitro Model Escherichia coli HB101 634468
Escherichia coli JM109 562
Acidaminococcus fermentans RYC-MR95 905
Acidaminococcus fermentans RYC4093 905
Acidaminococcus fermentans RYC4356 905
Escherichia coli RYC1000 562
Experiment for
Molecule Alteration		 Whole genome sequence assay
Experiment for
Drug Resistance		 Agar dilution method assay; broth microdilution method assay
Mechanism Description A. intestini is the first Gram-negative coccus with demonstrated resistance to beta-lactam antibiotics. The reference genome of the A. intestini strain RyC-MR95, which was isolated from a perianal abscess of a European male diabetic patient, contains the aci1 gene, which encodes the ACI-1 class A beta-lactamase that confers resistance to penicillins and extended-spectrum cephalosporins.
Cefotaxime
Click to Show/Hide
Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Drug Inactivation by Structure Modification (DISM) Click to Show/Hide
Disease Class: Anaerobic Bacterial infection [1], [2]
Resistant Disease Anaerobic Bacterial infection [ICD-11: 1A00-1A09]
 Disease Info 
Resistant Drug Cefotaxime
 Drug Info 
Molecule Alteration Expression
Up-regulation
Experimental Note Identified from the Human Clinical Data
In Vitro Model Escherichia coli HB101 634468
Escherichia coli JM109 562
Acidaminococcus fermentans RYC-MR95 905
Acidaminococcus fermentans RYC4093 905
Acidaminococcus fermentans RYC4356 905
Escherichia coli RYC1000 562
Experiment for
Molecule Alteration		 Whole genome sequence assay
Experiment for
Drug Resistance		 Agar dilution method assay; broth microdilution method assay
Mechanism Description A. intestini is the first Gram-negative coccus with demonstrated resistance to beta-lactam antibiotics. The reference genome of the A. intestini strain RyC-MR95, which was isolated from a perianal abscess of a European male diabetic patient, contains the aci1 gene, which encodes the ACI-1 class A beta-lactamase that confers resistance to penicillins and extended-spectrum cephalosporins.
Ceftazidime
Click to Show/Hide
Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Drug Inactivation by Structure Modification (DISM) Click to Show/Hide
Disease Class: Anaerobic Bacterial infection [1], [2]
Resistant Disease Anaerobic Bacterial infection [ICD-11: 1A00-1A09]
 Disease Info 
Resistant Drug Ceftazidime
 Drug Info 
Molecule Alteration Expression
Up-regulation
Experimental Note Identified from the Human Clinical Data
In Vitro Model Escherichia coli HB101 634468
Escherichia coli JM109 562
Acidaminococcus fermentans RYC-MR95 905
Acidaminococcus fermentans RYC4093 905
Acidaminococcus fermentans RYC4356 905
Escherichia coli RYC1000 562
Experiment for
Molecule Alteration		 Whole genome sequence assay
Experiment for
Drug Resistance		 Agar dilution method assay; broth microdilution method assay
Mechanism Description A. intestini is the first Gram-negative coccus with demonstrated resistance to beta-lactam antibiotics. The reference genome of the A. intestini strain RyC-MR95, which was isolated from a perianal abscess of a European male diabetic patient, contains the aci1 gene, which encodes the ACI-1 class A beta-lactamase that confers resistance to penicillins and extended-spectrum cephalosporins.
Penicillin
Click to Show/Hide
Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Drug Inactivation by Structure Modification (DISM) Click to Show/Hide
Disease Class: Anaerobic bacterial infection [1], [2]
Resistant Disease Anaerobic bacterial infection [ICD-11: 1A00-1A09]
 Disease Info 
Resistant Drug Penicillin
 Drug Info 
Molecule Alteration Expression
Up-regulation
Experimental Note Identified from the Human Clinical Data
In Vitro Model Escherichia coli HB101 634468
Escherichia coli JM109 562
Acidaminococcus fermentans RYC-MR95 905
Acidaminococcus fermentans RYC4093 905
Acidaminococcus fermentans RYC4356 905
Escherichia coli RYC1000 562
Experiment for
Molecule Alteration		 Whole genome sequence assay
Experiment for
Drug Resistance		 Agar dilution method assay; broth microdilution method assay
Mechanism Description A. intestini is the first Gram-negative coccus with demonstrated resistance to beta-lactam antibiotics. The reference genome of the A. intestini strain RyC-MR95, which was isolated from a perianal abscess of a European male diabetic patient, contains the aci1 gene, which encodes the ACI-1 class A beta-lactamase that confers resistance to penicillins and extended-spectrum cephalosporins.
Ticarcillin
Click to Show/Hide
Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Drug Inactivation by Structure Modification (DISM) Click to Show/Hide
Disease Class: Anaerobic Bacterial infection [1], [2]
Resistant Disease Anaerobic Bacterial infection [ICD-11: 1A00-1A09]
 Disease Info 
Resistant Drug Ticarcillin
 Drug Info 
Molecule Alteration Expression
Up-regulation
Experimental Note Identified from the Human Clinical Data
In Vitro Model Escherichia coli HB101 634468
Escherichia coli JM109 562
Acidaminococcus fermentans RYC-MR95 905
Acidaminococcus fermentans RYC4093 905
Acidaminococcus fermentans RYC4356 905
Escherichia coli RYC1000 562
Experiment for
Molecule Alteration		 Whole genome sequence assay
Experiment for
Drug Resistance		 Agar dilution method assay; broth microdilution method assay
Mechanism Description A. intestini is the first Gram-negative coccus with demonstrated resistance to beta-lactam antibiotics. The reference genome of the A. intestini strain RyC-MR95, which was isolated from a perianal abscess of a European male diabetic patient, contains the aci1 gene, which encodes the ACI-1 class A beta-lactamase that confers resistance to penicillins and extended-spectrum cephalosporins.
References
Ref 1 ACI-1 from Acidaminococcus fermentans: characterization of the first beta-lactamase in Anaerobic cocci. Antimicrob Agents Chemother. 2000 Nov;44(11):3144-9. doi: 10.1128/AAC.44.11.3144-3149.2000.
Ref 2 ACI-1 beta-lactamase is widespread across human gut microbiomes in Negativicutes due to transposons harboured by tailed prophages. Environ Microbiol. 2018 Jun;20(6):2288-2300. doi: 10.1111/1462-2920.14276. Epub 2018 Aug 7.

If you find any error in data or bug in web service, please kindly report it to Dr. Sun and Dr. Zhang.