Molecule Information
General Information of the Molecule (ID: Mol00775)
Name |
Aminoglycoside (3'') (9) adenylyltransferase (AADA)
,Vibrio cholerae
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Molecule Type |
Protein
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Gene Name |
aadA1
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Gene ID | |||||
Sequence |
MREAVIAEVSTQLSEVVGVIERHLEPTLLAVHLYGSAVDGGLKPHSDIDLLVTVTVRLDE
TTRRALINDLLETSASPGESEILRAVEVTIVVHDDIIPWRYPAKRELQFGEWQRNDILAG IFEPATIDIDLAILLTKAREHSVALVGPAAEELFDPVPEQDLFEALNETLTLWNSPPDWA GDERNVVLTLSRIWYSAVTGKIAPKDVAADWAMERLPAQYQPVILEARQAYLGQEEDRLA SRADQLEEFVHYVKGEITKVVGK Click to Show/Hide
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Uniprot ID | |||||
Click to Show/Hide the Complete Species Lineage | |||||
Type(s) of Resistant Mechanism of This Molecule
ADTT: Aberration of the Drug's Therapeutic Target
UAPP: Unusual Activation of Pro-survival Pathway
Drug Resistance Data Categorized by Drug
Approved Drug(s)
6 drug(s) in total
Ampicillin
Drug Resistance Data Categorized by Their Corresponding Mechanisms | ||||
Unusual Activation of Pro-survival Pathway (UAPP) | ||||
Disease Class: Vibrio cholerae infection | [1] | |||
Resistant Disease | Vibrio cholerae infection [ICD-11: 1A00.0] | |||
Resistant Drug | Ampicillin | |||
Molecule Alteration | Expression | Inherence |
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Experimental Note | Identified from the Human Clinical Data | |||
In Vitro Model | Vibrio cholerae O26 strain AS482 | 567107 | ||
Vibrio cholerae O39 strain AS634 | 666 | |||
Experiment for Molecule Alteration |
PCR and DNA sequencing assay | |||
Experiment for Drug Resistance |
Commercial antimicrobial discs assay | |||
Mechanism Description | The expression of aadA1-S lead to drug resistance. |
Framycetin
Drug Resistance Data Categorized by Their Corresponding Mechanisms | ||||
Aberration of the Drug's Therapeutic Target (ADTT) | ||||
Disease Class: Vibrio cholerae infection | [1] | |||
Resistant Disease | Vibrio cholerae infection [ICD-11: 1A00.0] | |||
Resistant Drug | Framycetin | |||
Molecule Alteration | Expression | Inherence |
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Experimental Note | Identified from the Human Clinical Data | |||
In Vitro Model | Vibrio cholerae O39 strain AS634 | 666 | ||
Experiment for Molecule Alteration |
PCR and DNA sequencing assay | |||
Experiment for Drug Resistance |
Commercial antimicrobial discs assay | |||
Mechanism Description | The expression of aadA1-S lead to drug resistance. |
Furazolidone
Drug Resistance Data Categorized by Their Corresponding Mechanisms | ||||
Unusual Activation of Pro-survival Pathway (UAPP) | ||||
Disease Class: Vibrio cholerae infection | [1] | |||
Resistant Disease | Vibrio cholerae infection [ICD-11: 1A00.0] | |||
Resistant Drug | Furazolidone | |||
Molecule Alteration | Expression | Inherence |
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Experimental Note | Identified from the Human Clinical Data | |||
In Vitro Model | Vibrio cholerae O26 strain AS482 | 567107 | ||
Vibrio cholerae O39 strain AS634 | 666 | |||
Experiment for Molecule Alteration |
PCR and DNA sequencing assay | |||
Experiment for Drug Resistance |
Commercial antimicrobial discs assay | |||
Mechanism Description | The expression of aadA1-S lead to drug resistance. |
Nalidixic acid
Drug Resistance Data Categorized by Their Corresponding Mechanisms | ||||
Unusual Activation of Pro-survival Pathway (UAPP) | ||||
Disease Class: Vibrio cholerae infection | [1] | |||
Resistant Disease | Vibrio cholerae infection [ICD-11: 1A00.0] | |||
Resistant Drug | Nalidixic acid | |||
Molecule Alteration | Expression | Inherence |
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Experimental Note | Identified from the Human Clinical Data | |||
In Vitro Model | Vibrio cholerae O26 strain AS482 | 567107 | ||
Experiment for Molecule Alteration |
PCR and DNA sequencing assay | |||
Experiment for Drug Resistance |
Commercial antimicrobial discs assay | |||
Mechanism Description | The expression of aadA1-S lead to drug resistance. |
Streptomycin
Drug Resistance Data Categorized by Their Corresponding Mechanisms | ||||
Aberration of the Drug's Therapeutic Target (ADTT) | ||||
Disease Class: Vibrio cholerae infection | [1] | |||
Resistant Disease | Vibrio cholerae infection [ICD-11: 1A00.0] | |||
Resistant Drug | Streptomycin | |||
Molecule Alteration | Expression | Inherence |
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Experimental Note | Identified from the Human Clinical Data | |||
In Vitro Model | Vibrio cholerae O26 strain AS482 | 567107 | ||
Vibrio cholerae O39 strain AS634 | 666 | |||
Experiment for Molecule Alteration |
PCR and DNA sequencing assay | |||
Experiment for Drug Resistance |
Commercial antimicrobial discs assay | |||
Mechanism Description | The expression of aadA1-S lead to drug resistance. |
Trimethoprim
Drug Resistance Data Categorized by Their Corresponding Mechanisms | ||||
Unusual Activation of Pro-survival Pathway (UAPP) | ||||
Disease Class: Vibrio cholerae infection | [1] | |||
Resistant Disease | Vibrio cholerae infection [ICD-11: 1A00.0] | |||
Resistant Drug | Trimethoprim | |||
Molecule Alteration | Expression | Inherence |
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Experimental Note | Identified from the Human Clinical Data | |||
In Vitro Model | Vibrio cholerae O39 strain AS634 | 666 | ||
Experiment for Molecule Alteration |
PCR and DNA sequencing assay | |||
Experiment for Drug Resistance |
Commercial antimicrobial discs assay | |||
Mechanism Description | The expression of aadA1-S lead to drug resistance. |
Investigative Drug(s)
1 drug(s) in total
Sulfamethizole/Sulfadiazine
Drug Resistance Data Categorized by Their Corresponding Mechanisms | ||||
Aberration of the Drug's Therapeutic Target (ADTT) | ||||
Disease Class: Vibrio cholerae infection | [1] | |||
Resistant Disease | Vibrio cholerae infection [ICD-11: 1A00.0] | |||
Resistant Drug | Sulfamethizole/Sulfadiazine | |||
Molecule Alteration | Expression | Inherence |
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Experimental Note | Identified from the Human Clinical Data | |||
In Vitro Model | Vibrio cholerae O26 strain AS482 | 567107 | ||
Experiment for Molecule Alteration |
PCR and DNA sequencing assay | |||
Experiment for Drug Resistance |
Commercial antimicrobial discs assay | |||
Mechanism Description | The expression of aadA1-S lead to drug resistance. |
References
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