Drug Information

Drug (ID: DG00499) and It's Reported Resistant Information
Name
Sulfamethizole/Sulfadiazine
Drug Resistance Disease(s)
Disease(s) with Clinically Reported Resistance for This Drug (1 diseases)
Cholera [ICD-11: 1A00]
[1]
Type(s) of Resistant Mechanism of This Drug
  ADTT: Aberration of the Drug's Therapeutic Target
  DISM: Drug Inactivation by Structure Modification
Drug Resistance Data Categorized by Their Corresponding Diseases
ICD-01: Infectious/parasitic diseases
Click to Show/Hide the Resistance Disease of This Class
Cholera [ICD-11: 1A00]
Click to Show/Hide
Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Aberration of the Drug's Therapeutic Target (ADTT) Click to Show/Hide
Key Molecule: Dihydrofolate reductase (DHFR) [1]
Molecule Alteration Expression
Inherence
 Molecule Info 
Resistant Disease Vibrio cholerae infection [ICD-11: 1A00.0]
 Disease Info 
Experimental Note Identified from the Human Clinical Data
In Vitro Model Vibrio cholerae O62 strain AS438 666
Vibrio cholerae PG149a 666
Vibrio cholerae PG224 666
Vibrio cholerae PG262(b) 666
Vibrio cholerae PG9 666
Vibrio cholerae PG95 666
Vibrio cholerae PL1 666
Vibrio cholerae PL61 666
Vibrio cholerae PL78/6 666
Vibrio cholerae PL91 666
Vibrio cholerae PL105b 666
Vibrio cholerae PL141 666
Vibrio cholerae PG92 666
Vibrio cholerae PL134 666
Experiment for
Molecule Alteration		 PCR and DNA sequencing assay
Experiment for
Drug Resistance		 Commercial antimicrobial discs assay
Mechanism Description The expression of dfrA1 lead to drug resistance.
Key Molecule: AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase (AAC6IB) [1]
Molecule Alteration Expression
Inherence
 Molecule Info 
Resistant Disease Vibrio cholerae infection [ICD-11: 1A00.0]
 Disease Info 
Experimental Note Identified from the Human Clinical Data
In Vitro Model Vibrio cholerae PL107b 666
Experiment for
Molecule Alteration		 PCR and DNA sequencing assay
Experiment for
Drug Resistance		 Commercial antimicrobial discs assay
Mechanism Description The expression of aac(6')-Ib lead to drug resistance.
Key Molecule: Aminoglycoside (3'') (9) adenylyltransferase (AADA) [1]
Molecule Alteration Expression
Inherence
 Molecule Info 
Resistant Disease Vibrio cholerae infection [ICD-11: 1A00.0]
 Disease Info 
Experimental Note Identified from the Human Clinical Data
In Vitro Model Vibrio cholerae O26 strain AS482 567107
Experiment for
Molecule Alteration		 PCR and DNA sequencing assay
Experiment for
Drug Resistance		 Commercial antimicrobial discs assay
Mechanism Description The expression of aadA1-S lead to drug resistance.
Key Molecule: Dihydrofolate reductase (DHFR) [1]
Molecule Alteration Expression
Inherence
 Molecule Info 
Resistant Disease Vibrio cholerae infection [ICD-11: 1A00.0]
 Disease Info 
Experimental Note Identified from the Human Clinical Data
In Vitro Model Vibrio cholerae PG153/1 666
Vibrio cholerae PG170 666
Vibrio cholerae PL96 666
Experiment for
Molecule Alteration		 PCR and DNA sequencing assay
Experiment for
Drug Resistance		 Commercial antimicrobial discs assay
Mechanism Description The expression of dfrA15 lead to drug resistance.
       Drug Inactivation by Structure Modification (DISM) Click to Show/Hide
Key Molecule: Erythromycin esterase (EREA2) [1]
Molecule Alteration Expression
Inherence
 Molecule Info 
Resistant Disease Vibrio cholerae infection [ICD-11: 1A00.0]
 Disease Info 
Experimental Note Identified from the Human Clinical Data
In Vitro Model Vibrio cholerae PG153/1 666
Vibrio cholerae PG170 666
Vibrio cholerae PL96 666
Experiment for
Molecule Alteration		 PCR and DNA sequencing assay
Experiment for
Drug Resistance		 Commercial antimicrobial discs assay
Mechanism Description The expression of dfrA5, ereA2 lead to drug resistance.
References
Ref 1 Occurrence of antibiotic resistance gene cassettes aac(6')-Ib, dfrA5, dfrA12, and ereA2 in class I integrons in non-O1, non-O139 Vibrio cholerae strains in India. Antimicrob Agents Chemother. 2002 Sep;46(9):2948-55. doi: 10.1128/AAC.46.9.2948-2955.2002.

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