Drug Information

Drug (ID: DG00445) and It's Reported Resistant Information
Name
Furazolidone
Synonyms
Bifuron; Corizium; Coryzium; Diafuron; Enterotoxon; Furall; Furaxon; Furaxone; Furazol; Furazolidine; Furazolidon; Furazolidona; Furazolidonum; Furazolum; Furazon; Furidon; Furovag; Furox; Furoxal; Furoxane; Furoxon; Furoxone; Furozolidine; Giardil; Giarlam; Medaron; Neftin; Nicolen; Nifulidone; Nifuran; Nifurazolidone; Nifurazolidonum; Nitrofurazolidone; Nitrofurazolidonum; Nitrofuroxon; Optazol; Ortazol; Puradin; Roptazol; Sclaventerol; Tikofuran; Topazone; Trichofuron; Tricofuron; Tricoron; Trifurox; Viofuragyn; Fiurox aerosol powder; Furoxone Liquid; Furoxone Swine Mix; NF 180 custom mix ten; F-8900; Furazolidona [INN-Spanish]; Furazolidone [INN:BAN]; Furazolidonum [INN-Latin]; Furox Aerosol Powder (Veterinary); Furoxone (TN); NF-180; Usaf ea-1; Dependal-M (TN); Furazolidone (USP/INN); N-(5-Nitro-2-furfurylidene)-3-amino-2-oxazolidone; N-(5-Nitro-2-furfurylidene)-3-aminooxazolidine-2-one; 3-(((5-Nitro-2-furanyl)methylene)amino)-2-oxazolidinone; 3-((5-Nitrofurfurylidene)amino)-2-oxazolidinone; 3-((5-Nitrofurfurylidene)amino)-2-oxazolidone; 3-((5-Nitrofurylidene)amino)-2-oxazolidone; 3-(5'-Nitrofurfuralamino)-2-oxazolidone; 3-(5-Nitrofurfurylideneamino)-2-oxazolidinone; 3-[(5-Nitrofurfurylidene)amino]-2-oxazolidinone; 3-[(5-Nitrofurfurylidene)amino]-2-oxazolidone; 3-[(5-Nitrofurylidene)amino]-2-oxazolidone; 3-[(E)-(5-nitrofuran-2-yl)methylideneamino]-1,3-oxazolidin-2-one; 3-[[(5-Nitro-2-furanyl)methylene]amino]-2-oxazolidinone; 3-{[(5-Nitro-2-furanyl)methylene]amino}-2-oxazolidinone; 3-{[(5-nitro-2-furyl)methylene]amino}-1,3-oxazolidin-2-one; 3-{[(E)-(5-nitrofuran-2-yl)methylidene]amino}-1,3-oxazolidin-2-one; 5-Nitro-N-(2-oxo-3-oxazolidinyl)-2-furanmethanimine
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Indication
In total 1 Indication(s)
Bowel habit change [ICD-11: ME05]
Approved
[1]
Structure
Drug Resistance Disease(s)
Disease(s) with Clinically Reported Resistance for This Drug (2 diseases)
Bacterial infection [ICD-11: 1A00-1C4Z]
[1]
Cholera [ICD-11: 1A00]
[2]
Target Bacterial Deoxyribonucleic acid (Bact DNA) NOUNIPROTAC [1]
Click to Show/Hide the Molecular Information and External Link(s) of This Drug
Formula
C8H7N3O5
IsoSMILES
C1COC(=O)N1/N=C/C2=CC=C(O2)[N+](=O)[O-]
InChI
1S/C8H7N3O5/c12-8-10(3-4-15-8)9-5-6-1-2-7(16-6)11(13)14/h1-2,5H,3-4H2/b9-5+
InChIKey
PLHJDBGFXBMTGZ-WEVVVXLNSA-N
PubChem CID
5323714
ChEBI ID
CHEBI:5195
TTD Drug ID
D03CUF
DrugBank ID
DB00614
Type(s) of Resistant Mechanism of This Drug
  DISM: Drug Inactivation by Structure Modification
  EADR: Epigenetic Alteration of DNA, RNA or Protein
  UAPP: Unusual Activation of Pro-survival Pathway
Drug Resistance Data Categorized by Their Corresponding Diseases
ICD-01: Infectious/parasitic diseases
Click to Show/Hide the Resistance Disease of This Class
Cholera [ICD-11: 1A00]
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Drug Inactivation by Structure Modification (DISM) Click to Show/Hide
Key Molecule: Erythromycin esterase (EREA2) [2]
Molecule Alteration Expression
Inherence
 Molecule Info 
Resistant Disease Vibrio cholerae infection [ICD-11: 1A00.0]
 Disease Info 
Experimental Note Identified from the Human Clinical Data
In Vitro Model Vibrio cholerae PG153/1 666
Vibrio cholerae PG170 666
Vibrio cholerae PL96 666
Experiment for
Molecule Alteration		 PCR and DNA sequencing assay
Experiment for
Drug Resistance		 Commercial antimicrobial discs assay
Mechanism Description The expression of dfrA5, ereA2 lead to drug resistance.
       Epigenetic Alteration of DNA, RNA or Protein (EADR) Click to Show/Hide
Key Molecule: AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase (AAC6IB) [2]
Molecule Alteration Expression
Inherence
 Molecule Info 
Resistant Disease Vibrio cholerae infection [ICD-11: 1A00.0]
 Disease Info 
Experimental Note Identified from the Human Clinical Data
In Vitro Model Vibrio cholerae PL107b 666
Experiment for
Molecule Alteration		 PCR and DNA sequencing assay
Experiment for
Drug Resistance		 Commercial antimicrobial discs assay
Mechanism Description The expression of aac(6')-Ib lead to drug resistance.
       Unusual Activation of Pro-survival Pathway (UAPP) Click to Show/Hide
Key Molecule: Aminoglycoside (3'') (9) adenylyltransferase (AADA) [2]
Molecule Alteration Expression
Inherence
 Molecule Info 
Resistant Disease Vibrio cholerae infection [ICD-11: 1A00.0]
 Disease Info 
Experimental Note Identified from the Human Clinical Data
In Vitro Model Vibrio cholerae O26 strain AS482 567107
Vibrio cholerae O39 strain AS634 666
Experiment for
Molecule Alteration		 PCR and DNA sequencing assay
Experiment for
Drug Resistance		 Commercial antimicrobial discs assay
Mechanism Description The expression of aadA1-S lead to drug resistance.
Key Molecule: Dihydrofolate reductase (DHFR) [2]
Molecule Alteration Expression
Inherence
 Molecule Info 
Resistant Disease Vibrio cholerae infection [ICD-11: 1A00.0]
 Disease Info 
Experimental Note Identified from the Human Clinical Data
In Vitro Model Vibrio cholerae O62 strain AS438 666
Vibrio cholerae PG149a 666
Vibrio cholerae PG224 666
Vibrio cholerae PG9 666
Vibrio cholerae PG95 666
Vibrio cholerae PL1 666
Vibrio cholerae PL61 666
Vibrio cholerae PL78/6 666
Vibrio cholerae PL105b 666
Vibrio cholerae PL141 666
Vibrio cholerae PG92 666
Vibrio cholerae PL134 666
Experiment for
Molecule Alteration		 PCR and DNA sequencing assay
Experiment for
Drug Resistance		 Commercial antimicrobial discs assay
Mechanism Description The expression of dfrA1 lead to drug resistance.
Key Molecule: Dihydrofolate reductase (DHFR) [2]
Molecule Alteration Expression
Inherence
 Molecule Info 
Resistant Disease Vibrio cholerae infection [ICD-11: 1A00.0]
 Disease Info 
Experimental Note Identified from the Human Clinical Data
In Vitro Model Vibrio cholerae PG153/1 666
Vibrio cholerae PG170 666
Vibrio cholerae PL96 666
Experiment for
Molecule Alteration		 PCR and DNA sequencing assay
Experiment for
Drug Resistance		 Commercial antimicrobial discs assay
Mechanism Description The expression of dfrA15 lead to drug resistance.
Bacterial infection [ICD-11: 1A00-1C4Z]
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Drug Inactivation by Structure Modification (DISM) Click to Show/Hide
Key Molecule: Aminoglycoside acetyltransferase (AAC) [1]
Molecule Alteration Expression
Inherence
 Molecule Info 
Resistant Disease Vibrio fluvialis infection [ICD-11: 1A00-1C4Z]
 Disease Info 
Experimental Note Identified from the Human Clinical Data
In Vitro Model Vibrio fluvialis H-08942 676
Experiment for
Molecule Alteration		 PCR; DNA sequencing assay; Southern hybridization assay; Cloning and expression assay
Experiment for
Drug Resistance		 Broth microdilution method assay
Mechanism Description Aac(3)-Id is a new type of aminoglycoside acetyltransferase gene which causes drug resistance.
References
Ref 1 New aminoglycoside acetyltransferase gene, aac(3)-Id, in a class 1 integron from a multiresistant strain of Vibrio fluvialis isolated from an infant aged 6 months. J Antimicrob Chemother. 2004 Jun;53(6):947-51. doi: 10.1093/jac/dkh221. Epub 2004 Apr 29.
Ref 2 Occurrence of antibiotic resistance gene cassettes aac(6')-Ib, dfrA5, dfrA12, and ereA2 in class I integrons in non-O1, non-O139 Vibrio cholerae strains in India. Antimicrob Agents Chemother. 2002 Sep;46(9):2948-55. doi: 10.1128/AAC.46.9.2948-2955.2002.

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