Drug Information
Drug (ID: DG00456) and It's Reported Resistant Information
| Name |
Sodium deoxycholate
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| Synonyms |
Sodium deoxycholate; 302-95-4; Deoxycholic acid sodium salt; Sodium desoxycholate; Deoxycholate sodium; Desoxycholate sodium; Sodium 7-deoxycholate; Deoxycholic acid, sodium salt; UNII-436LS6U35Y; 7-Deoxycholic acid sodium salt; CHEBI:9177; 3-alpha,12-alpha-Dihydroxy-5-beta-cholan-24-oic acid sodium salt; 436LS6U35Y; MFCD00064139; NCGC00091038-01; ATX 101; Cholan-24-oic acid, 3,12-dihydroxy-, monosodium salt, (3a,5b,12a)-; 3,12-Dihydroxy-cholan-24-oic acid monosodium salt, (3-alpha,5-beta,12-alpha)- (9CI); DSSTox_CID_13389; DSSTox_RID_79069; DSSTox_GSID_33389; Sodium deoxycholic acid; Na-Desoxycholat; Na-Desoxycholat [German]; Sodiumdeoxycholate; CAS-302-95-4; CCRIS 655; Deoxycholic acid sodium salt monohydrate; Desoxycholic acid sodium salt; EINECS 206-132-7; sodium (3alpha,5beta,12alpha)-3,12-dihydroxycholan-24-oate; Dihydroxy 3-12 cholanate de Na [French]; Dihydroxy 3-12 cholanate de Na; Natrium-3-alpha,12-alpha-dihydroxycholanat [German]; deoxycholic acid sodium; Sodium 3-alpha,12-alpha-dihydroxy-5-beta-cholan-24-oate; Natrium-3-alpha,12-alpha-dihydroxycholanat; 145224-92-6; SCHEMBL37482; MLS002695906; 3alpha,12alpha-Dihydroxy-5beta-cholanic acid sodium salt; CHEMBL1365278; DTXSID5033389; HY-N0593A; Deoxycholic acid sodium salt hydrate; Tox21_111066; Tox21_200896; 5-beta-Cholan-24-oic acid, 3-alpha,12-alpha-dihydroxy-, sodium salt; AKOS002391107; AKOS017345123; CS-8046; NSC 681065; Cholan-24-oic acid, 3,12-dihydroxy-, monosodium salt, (3alpha,5beta,12alpha)-; NCGC00258450-01; AC-24206; BP-31018; O134; SMR001562102; Sodium deoxycholate, >=97% (titration); 68512-EP2275413A1; 68512-EP2308855A1; Deoxycholic acid sodium salt, for electrophoresis; Sodium 3- ,12- -dihydroxy-5- -cholan-24-oate; Q-200935; Q25474151; sodium 3alpha,12alpha-dihydroxy-5beta-cholan-24-oate; Sodium deoxycholate, Vetec(TM) reagent grade, >=97%; Sodium deoxycholate, BioXtra, >=98.0% (dry matter, NT); Cholan-24-oic acid, 3,12-dihydroxy-, monosodium salt, (3-alpha,5-beta,12-alpha)- (9CI); Sodium deoxycholate, Suitable for manufacturing of diagnostic kits and reagents; sodium (4R)-4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoate; Sodium deoxycholate, PharmaGrade, Manufactured under appropriate controls for use as a raw material in pharma or biopharmaceutical production; sodium(4R)-4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoate; Sodium;(4R)-4-[(3R,5R,10S,12S,13R,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoate; sodium;(4R)-4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoate
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| Structure |
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| Drug Resistance Disease(s) |
Disease(s) with Clinically Reported Resistance for This Drug
(1 diseases)
Salmonellosis [ICD-11: 1A09]
[1]
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| Click to Show/Hide the Molecular Information and External Link(s) of This Drug | |||||
| Formula |
C24H39NaO4
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| IsoSMILES |
C[C@H](CCC(=O)[O-])[C@H]1CC[C@@H]2[C@@]1([C@H](C[C@H]3[C@H]2CC[C@H]4[C@@]3(CC[C@H](C4)O)C)O)C.[Na+]
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| InChI |
1S/C24H40O4.Na/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3;/h14-21,25-26H,4-13H2,1-3H3,(H,27,28);/q;+1/p-1/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-;/m1./s1
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| InChIKey |
FHHPUSMSKHSNKW-SMOYURAASA-M
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| PubChem CID | |||||
Type(s) of Resistant Mechanism of This Drug
IDUE: Irregularity in Drug Uptake and Drug Efflux
Drug Resistance Data Categorized by Their Corresponding Diseases
ICD-01: Infectious/parasitic diseases
Salmonellosis [ICD-11: 1A09]
| Drug Resistance Data Categorized by Their Corresponding Mechanisms | ||||
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Irregularity in Drug Uptake and Drug Efflux (IDUE)
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| Key Molecule: Multidrug resistance protein MdtC (MDTC) | [1] | |||
| Molecule Alteration | Expression | Up-regulation |
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| Resistant Disease | Salmonella enterica infection [ICD-11: 1A09.0] | |||
| Experimental Note | Identified from the Human Clinical Data | |||
| In Vitro Model | Salmonella enterica serovar Typhimurium ATCC 14028s | 588858 | ||
| Experiment for Molecule Alteration |
Quantitative real-time PCR | |||
| Experiment for Drug Resistance |
L agar plate method assay | |||
| Mechanism Description | Overexpression or overproduction of mdtABC confers drug resistance. | |||
| Key Molecule: Multidrug resistance protein MdtB (MDTB) | [1] | |||
| Molecule Alteration | Expression | Up-regulation |
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| Resistant Disease | Salmonella enterica infection [ICD-11: 1A09.0] | |||
| Experimental Note | Identified from the Human Clinical Data | |||
| In Vitro Model | Salmonella enterica serovar Typhimurium ATCC 14028s | 588858 | ||
| Experiment for Molecule Alteration |
Quantitative real-time PCR | |||
| Experiment for Drug Resistance |
L agar plate method assay | |||
| Mechanism Description | Overexpression or overproduction of mdtABC confers drug resistance. | |||
| Key Molecule: Multidrug resistance protein MdtA (MDTA) | [1] | |||
| Molecule Alteration | Expression | Up-regulation |
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| Resistant Disease | Salmonella enterica infection [ICD-11: 1A09.0] | |||
| Experimental Note | Identified from the Human Clinical Data | |||
| In Vitro Model | Salmonella enterica serovar Typhimurium ATCC 14028s | 588858 | ||
| Experiment for Molecule Alteration |
Quantitative real-time PCR | |||
| Experiment for Drug Resistance |
L agar plate method assay | |||
| Mechanism Description | Overexpression or overproduction of mdtABC confers drug resistance. | |||
| Key Molecule: Efflux pump membrane transporter (ACRD) | [1] | |||
| Molecule Alteration | Expression | Up-regulation |
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| Resistant Disease | Salmonella enterica infection [ICD-11: 1A09.0] | |||
| Experimental Note | Identified from the Human Clinical Data | |||
| In Vitro Model | Salmonella enterica serovar Typhimurium ATCC 14028s | 588858 | ||
| Experiment for Molecule Alteration |
Quantitative real-time PCR | |||
| Experiment for Drug Resistance |
L agar plate method assay | |||
| Mechanism Description | Overexpression or overproduction of acrD confers drug resistance. | |||
| Key Molecule: Multidrug export protein EmrA (EMRA) | [1] | |||
| Molecule Alteration | Expression | Up-regulation |
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| Resistant Disease | Salmonella enterica infection [ICD-11: 1A09.0] | |||
| Experimental Note | Identified from the Human Clinical Data | |||
| In Vitro Model | Salmonella enterica serovar Typhimurium ATCC 14028s | 588858 | ||
| Experiment for Molecule Alteration |
Quantitative real-time PCR | |||
| Experiment for Drug Resistance |
L agar plate method assay | |||
| Mechanism Description | Overexpression or overproduction of emrAB confers drug resistance. | |||
| Key Molecule: Multidrug export protein EmrB (EMRB) | [1] | |||
| Molecule Alteration | Expression | Up-regulation |
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| Resistant Disease | Salmonella enterica infection [ICD-11: 1A09.0] | |||
| Experimental Note | Identified from the Human Clinical Data | |||
| In Vitro Model | Salmonella enterica serovar Typhimurium ATCC 14028s | 588858 | ||
| Experiment for Molecule Alteration |
Quantitative real-time PCR | |||
| Experiment for Drug Resistance |
L agar plate method assay | |||
| Mechanism Description | Overexpression or overproduction of emrAB confers drug resistance. | |||
| Key Molecule: Efflux pump membrane transporter MdsA (MDSA) | [1] | |||
| Molecule Alteration | Expression | Up-regulation |
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| Resistant Disease | Salmonella enterica infection [ICD-11: 1A09.0] | |||
| Experimental Note | Identified from the Human Clinical Data | |||
| In Vitro Model | Salmonella enterica serovar Typhimurium ATCC 14028s | 588858 | ||
| Experiment for Molecule Alteration |
Quantitative real-time PCR | |||
| Experiment for Drug Resistance |
L agar plate method assay | |||
| Mechanism Description | Overexpression or overproduction of MdsABC confers drug resistance. | |||
| Key Molecule: Efflux pump membrane transporter MdsB (MDSB) | [1] | |||
| Molecule Alteration | Expression | Up-regulation |
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| Resistant Disease | Salmonella enterica infection [ICD-11: 1A09.0] | |||
| Experimental Note | Identified from the Human Clinical Data | |||
| In Vitro Model | Salmonella enterica serovar Typhimurium ATCC 14028s | 588858 | ||
| Experiment for Molecule Alteration |
Quantitative real-time PCR | |||
| Experiment for Drug Resistance |
L agar plate method assay | |||
| Mechanism Description | Overexpression or overproduction of MdsABC confers drug resistance. | |||
| Key Molecule: Efflux pump membrane transporter MdsC (MDSC) | [1] | |||
| Molecule Alteration | Expression | Up-regulation |
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| Resistant Disease | Salmonella enterica infection [ICD-11: 1A09.0] | |||
| Experimental Note | Identified from the Human Clinical Data | |||
| In Vitro Model | Salmonella enterica serovar Typhimurium ATCC 14028s | 588858 | ||
| Experiment for Molecule Alteration |
Quantitative real-time PCR | |||
| Experiment for Drug Resistance |
L agar plate method assay | |||
| Mechanism Description | Overexpression or overproduction of MdsABC confers drug resistance. | |||
References
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