Disease Information

General Information of the Disease (ID: DIS00234)

• Name: Hereditary angioedema
• ICD: ICD-11: 4B05

Type(s) of Resistant Mechanism of This Disease

  UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Stanozolol

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Unusual Activation of Pro-survival Pathway (UAPP)

Key Molecule: Apoptosis regulator BAX (BAX) [1]

• Resistant Disease: Hereditary angioedema [ICD-11: 4B05.0]
• Molecule Alteration: Expression; Up-regulation
• Resistant Drug: Stanozolol
• Experimental Note: Discovered Using In-vivo Testing Model
• In Vivo Model: Sprague Dawley male rats model; Rattus norvegicus
• Experiment for Molecule Alteration: Gene expression analysis
• Mechanism Description: Stanozolol can increases levels of Bax, Bcl-2, P53, caspase 3 and Bax/Bcl-2 ratio. Resistance training, 50 and 100 mg/kg Tribulus terrestris and resistance training along with Tribulus terrestris can decrease the Bax, Bcl-2, P53, caspase 3 and Bax/Bcl-2 ratio in rats exposed to Stanozolol.

Key Molecule: Apoptosis regulator Bcl-2 (BCL2) [1]

• Resistant Disease: Hereditary angioedema [ICD-11: 4B05.0]
• Molecule Alteration: Expression; Up-regulation
• Resistant Drug: Stanozolol
• Experimental Note: Discovered Using In-vivo Testing Model
• In Vivo Model: Sprague Dawley male rats model; Rattus norvegicus
• Experiment for Molecule Alteration: Gene expression analysis
• Mechanism Description: Stanozolol can increases levels of Bax, Bcl-2, P53, caspase 3 and Bax/Bcl-2 ratio. Resistance training, 50 and 100 mg/kg Tribulus terrestris and resistance training along with Tribulus terrestris can decrease the Bax, Bcl-2, P53, caspase 3 and Bax/Bcl-2 ratio in rats exposed to Stanozolol.

Key Molecule: Caspase-3 (CASP3) [1]

• Resistant Disease: Hereditary angioedema [ICD-11: 4B05.0]
• Molecule Alteration: Expression; Up-regulation
• Resistant Drug: Stanozolol
• Experimental Note: Discovered Using In-vivo Testing Model
• In Vivo Model: Sprague Dawley male rats model; Rattus norvegicus
• Experiment for Molecule Alteration: Gene expression analysis
• Mechanism Description: Stanozolol can increases levels of Bax, Bcl-2, P53, caspase 3 and Bax/Bcl-2 ratio. Resistance training, 50 and 100 mg/kg Tribulus terrestris and resistance training along with Tribulus terrestris can decrease the Bax, Bcl-2, P53, caspase 3 and Bax/Bcl-2 ratio in rats exposed to Stanozolol.

Key Molecule: Cellular tumor antigen p53 (TP53) [1]

• Resistant Disease: Hereditary angioedema [ICD-11: 4B05.0]
• Molecule Alteration: Expression; Up-regulation
• Resistant Drug: Stanozolol
• Experimental Note: Discovered Using In-vivo Testing Model
• In Vivo Model: Sprague Dawley male rats model; Rattus norvegicus
• Experiment for Molecule Alteration: Gene expression analysis
• Mechanism Description: Stanozolol can increases levels of Bax, Bcl-2, P53, caspase 3 and Bax/Bcl-2 ratio. Resistance training, 50 and 100 mg/kg Tribulus terrestris and resistance training along with Tribulus terrestris can decrease the Bax, Bcl-2, P53, caspase 3 and Bax/Bcl-2 ratio in rats exposed to Stanozolol.

References

• Ref 1: Anti-Apoptotic Effects of Resistance Training and Tribulus Terrestris Consumption in the Heart Tissue of Rats Exposed to Stanozolol .Eurasian J Med. 2021 Jun;53(2):79-84. doi: 10.5152/eurasianjmed.2021.20051. 10.5152/eurasianjmed.2021.20051