Molecule Information

General Information of the Molecule (ID: Mol04018)
Name
Carbonic anhydrase 13 (CA13) ,Homo sapiens
Synonyms
Carbonate dehydratase XIII; Carbonic anhydrase XIII
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Molecule Type
Protein
Gene Name
CA13
Gene ID
377677
Location
chr8:85220587-85284073[+]
Sequence
MSRLSWGYREHNGPIHWKEFFPIADGDQQSPIEIKTKEVKYDSSLRPLSIKYDPSSAKII
SNSGHSFNVDFDDTENKSVLRGGPLTGSYRLRQVHLHWGSADDHGSEHIVDGVSYAAELH
VVHWNSDKYPSFVEAAHEPDGLAVLGVFLQIGEPNSQLQKITDTLDSIKEKGKQTRFTNF
DLLSLLPPSWDYWTYPGSLTVPPLLESVTWIVLKQPINISSQQLAKFRSLLCTAEGEAAA
FLVSNHRPPQPLKGRKVRASFH
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3D-structure
PDB ID
3D0N
Classification
Metal binding protein
Method
X-ray diffraction
Resolution
1.55  Å
Function
Reversible hydration of carbon dioxide.
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Uniprot ID
CAH13_HUMAN
Ensembl ID
ENSG00000185015
HGNC ID
HGNC:14914
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Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Type(s) of Resistant Mechanism of This Molecule
  MRAP: Metabolic Reprogramming via Altered Pathways
Drug Resistance Data Categorized by Drug
Approved Drug(s)
1 drug(s) in total
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Doxorubicin
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
  Metabolic Reprogramming via Altered Pathways (MRAP) Click to Show/Hide
Disease Class: Acute myeloid leukemia [ICD-11: 2A60.0] [1]
Metabolic Type Lipid metabolism
Resistant Disease Acute myeloid leukemia [ICD-11: 2A60.0]
 Disease Info 
Resistant Drug Doxorubicin
 Drug Info 
Molecule Alteration Expression
Up-regulation
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model HL-60 cells Peripheral blood Homo sapiens (Human) CVCL_0002
K562 cells Blood Homo sapiens (Human) CVCL_0004
THP1 cells Pleural effusion Homo sapiens (Human) CVCL_0006
Experiment for
Drug Resistance		 IC50 assay
Mechanism Description CA13is involved in cellular pH regulation, carbon dioxide transport, and cell homeostasis. Abnormalities in these processes can affect the tumor microenvironment, influencing cancer cell survival, proliferation, and resistance to therapy
References
Ref 1 Prognostic implications of metabolism-related genes in acute myeloid leukemia. Front Genet. 2024 Oct 3;15:1424365.

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