Molecule Information

General Information of the Molecule (ID: Mol01090)

• Name: Sterol 14-alpha demethylase cyp51A (CYP51A) ,Aspergillus niger
• Synonyms: ABL_04779
• Molecule Type: Protein
• Gene Name: ABL_04779
• Sequence:
  MAAIAPNPLNAPDTAVSGQSDCQHHWSLAWFDTLSKGSPSGLIRLRNHREQCLLPLLTVF
  ANHCSGWTDVAQCQGHEPTTTYSFDVLLLTFSFTNTFPINWSFFLPTVASRMAYLAVAGA
  YAFAALLVAIVLNVARQLLVRNEKEPPVVFHWIPFLGSTISYGMDPYAFFFSCRKKYGDI
  FTFVLLGKKTTVYLGVQGNDFILNGKLKDVSAEEVYSPLTTPVFGSDVVYDCPNSKLMEQ
  KKFIKFGLTQAALESHVQLIEKETLDYLRDSPRFNGASGVIDIPAAMAEITIYTAARALQ
  GEEVRKKLTAEFAELYHDLDKGFSPINFMLPWAPLPHNRKRDAAHARMREIYTDIINERR
  KNPDEEKSDMIWNLMHCTYKNGQPVPDKEIAHMMITLLMAGQHSSSSISSWIMLRLASEP
  QVLEELYQEQLTSLSNRNGVFEPLQYQDLDKLPLLQSVIKETLRIHSSIHSIMRKVKNPL
  PVPGTSYVIPEDRVLLASPGVTALSDEYFPNATRWDPHRWENQPDKEEEGEMVDYGYGSV
  SKGTASPYLPFGAGRHRCIGEKFAYVNLGVIIATIVRHLKLFNVDGRKGVPGTDYSTLFS
  GPLKPAIVGWERRIQDNSKGSLN
• Uniprot ID: A0A100IIZ2_ASPNG

Kingdom: Fungi
Phylum: Ascomycota
Class: Eurotiomycetes
Order: Eurotiales
Family: Aspergillaceae
Genus: Aspergillus
Species: Aspergillus niger

Type(s) of Resistant Mechanism of This Molecule

  ADTT: Aberration of the Drug's Therapeutic Target

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Posaconazole

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Aberration of the Drug's Therapeutic Target (ADTT)

Disease Class: Aspergillus niger infection [1]

• Resistant Disease: Aspergillus niger infection [ICD-11: 1F20.3]
• Resistant Drug: Posaconazole
• Molecule Alteration: Missense mutation; p.R228Q
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Aspergillus niger strain; 5061
• Experiment for Molecule Alteration: PCR amplification and sequence analysis
• Experiment for Drug Resistance: Broth microdilution method assay
• Mechanism Description: Amino acid changes in ERG11 may contribute to Candida albicans emerging posaconazole resistance.

References

• Ref 1: Species Distribution and In Vitro Azole Susceptibility of Aspergillus Section Nigri Isolates from Clinical and Environmental Settings. J Clin Microbiol. 2016 Sep;54(9):2365-72. doi: 10.1128/JCM.01075-16. Epub 2016 Jul 13.