Drug Information

Drug (ID: DG02008) and It's Reported Resistant Information

• Name: HA344
• Synonyms: 36061-08-2|(R)-2-Amino-5-phenylpentanoic acid|(2R)-2-amino-5-phenylpentanoic acid|(R)-2-Amino-5-phenyl-pentanoic acid|D-2-Amino-5-phenyl-pentanoic acid|Benzenepentanoic acid, a-amino-, (R)-|(2R)-2-azaniumyl-5-phenylpentanoate|H-D-Phe{#(CH2)2}-OH|(R)-2-Amino-5-phenylpentanoicacid|MFCD03844654|(2R)-2-amino-5-phenyl-pentanoic acid|SCHEMBL2130589|XOQZTHUXZWQXOK-SNVBAGLBSA-N|2(r)-amino-5-phenyl-pentanoic acid|2-(R)-Amino-5-phenylpentanoic acid|AKOS006343927|AC-9944|PS-12532|DS-018116|CS-0005262|W15607|848-211-4
• Indication:
  In total 1 Indication(s)
  . .; .
• Formula: C11H15NO2
• IsoSMILES: C1=CC=C(C=C1)CCC[C@H](C(=O)O)N
• InChI: InChI=1S/C11H15NO2/c12-10(11(13)14)8-4-7-9-5-2-1-3-6-9/h1-3,5-6,10H,4,7-8,12H2,(H,13,14)/t10-/m1/s1
• InChIKey: XOQZTHUXZWQXOK-SNVBAGLBSA-N
• PubChem CID: 6993756

Type(s) of Resistant Mechanism of This Drug

  MRAP: Metabolic Reprogramming via Altered Pathways

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-02: Benign/in-situ/malignant neoplasm

Metastatic melanoma [ICD-11: 2E08]

Drug Sensitivity Data Categorized by Their Corresponding Mechanisms

Metabolic Reprogramming via Altered Pathways (MRAP)

Key Molecule: Pyruvate kinase M2 (PKM) [1]

• Metabolic Type: Glucose metabolism
• Sensitive Disease: Cutaneous metastatic melanoma [ICD-11: 2E08.0]
• Molecule Alteration: Expression; Down-regulation
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: A375 cells; Skin; Homo sapiens (Human); CVCL_0132
• In Vitro Model: SkMEL28 cells; Skin; Homo sapiens (Human); CVCL_0526
• Experiment for Molecule Alteration: Western blot analysis
• Experiment for Drug Resistance: Cell viability assay
• Mechanism Description: the mechanism of action of HA344 provides potential therapeutic avenues for patients with CMM and a broad range of different cancers

Key Molecule: Pyruvate kinase M2 (PKM) [1]

• Metabolic Type: Glucose metabolism
• Sensitive Disease: Cutaneous metastatic melanoma [ICD-11: 2E08.0]
• Molecule Alteration: Expression; Down-regulation
• Experimental Note: Revealed Based on the Cell Line Data
• In Vivo Model: A375 S cells, Five weeks old female athymic nude mice; A375R cells, Five weeks old female athymic nude mice; Mice
• Experiment for Molecule Alteration: Western blot analysis
• Experiment for Drug Resistance: Tumor volume assay
• Mechanism Description: the mechanism of action of HA344 provides potential therapeutic avenues for patients with CMM and a broad range of different cancers

References

• Ref 1: Dual Covalent Inhibition of PKM and IMPDH Targets Metabolism in Cutaneous Metastatic Melanoma. Cancer Res. 2021 Jul 15;81(14):3806-3821.