Disease Information

General Information of the Disease (ID: DIS00533)

• Name: Metastatic melanoma
• ICD: ICD-11: 2E08

Type(s) of Resistant Mechanism of This Disease

  MRAP: Metabolic Reprogramming via Altered Pathways

Drug Resistance Data Categorized by Drug

Preclinical Drug(s) 1 drug(s) in total

HA344

Drug Sensitivity Data Categorized by Their Corresponding Mechanisms

Metabolic Reprogramming via Altered Pathways (MRAP)

Key Molecule: Pyruvate kinase M2 (PKM) [1]

• Metabolic Type: Glucose metabolism
• Sensitive Disease: Cutaneous metastatic melanoma [ICD-11: 2E08.0]
• Sensitive Drug: HA344
• Molecule Alteration: Expression; Down-regulation
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: A375 cells; Skin; Homo sapiens (Human); CVCL_0132
• In Vitro Model: SkMEL28 cells; Skin; Homo sapiens (Human); CVCL_0526
• Experiment for Molecule Alteration: Western blot analysis
• Experiment for Drug Resistance: Cell viability assay
• Mechanism Description: the mechanism of action of HA344 provides potential therapeutic avenues for patients with CMM and a broad range of different cancers

Key Molecule: Pyruvate kinase M2 (PKM) [1]

• Metabolic Type: Glucose metabolism
• Sensitive Disease: Cutaneous metastatic melanoma [ICD-11: 2E08.0]
• Sensitive Drug: HA344
• Molecule Alteration: Expression; Down-regulation
• Experimental Note: Revealed Based on the Cell Line Data
• In Vivo Model: A375 S cells, Five weeks old female athymic nude mice; A375R cells, Five weeks old female athymic nude mice; Mice
• Experiment for Molecule Alteration: Western blot analysis
• Experiment for Drug Resistance: Tumor volume assay
• Mechanism Description: the mechanism of action of HA344 provides potential therapeutic avenues for patients with CMM and a broad range of different cancers

References

• Ref 1: Dual Covalent Inhibition of PKM and IMPDH Targets Metabolism in Cutaneous Metastatic Melanoma. Cancer Res. 2021 Jul 15;81(14):3806-3821.