Drug Information

Drug (ID: DG00430) and It's Reported Resistant Information

• Name: Tetraphenylphosphonium chloride
• Synonyms: Tetraphenylphosphonium chloride; 2001-45-8; Phosphonium, tetraphenyl-, chloride; tetraphenylphosphanium;chloride; MFCD00011916; tetraphenylphophonium chloride; EINECS 217-890-3; Ph4PCl; Tetraphenylphosphonium chloride, 98%; tetraphenylchlorophosphine; Phosphonium, tetraphenyl-, chloride (1:1); C24H20ClP; Tetraphenylphosphoniumchloride; tetraphenylphosphanium,chloride; SCHEMBL126056; CHEMBL223885; DTXSID00897533; AKOS015833164; TETRAPHENYL-PHOSPHONIUM-CHLORIDE; AS-15199; O459; SY032650; DB-045062; CS-0097966; FT-0633970; T1375; F15456; A855066; Q7706653; W-107657; Tetraphenylphosphonium chloride, for the spectrophotometric det. of Bi, Co, >=97.0%
• Drug Resistance Disease(s):
  Disease(s) with Clinically Reported Resistance for This Drug (2 diseases)
  Bacterial infection [ICD-11: 1A00-1C4Z]; [1]
  Pneumonia [ICD-11: CA40]; [2]
• Formula: C24H20ClP
• IsoSMILES: C1=CC=C(C=C1)[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4.[Cl-]
• InChI: 1S/C24H20P.ClH/c1-5-13-21(14-6-1)25(22-15-7-2-8-16-22,23-17-9-3-10-18-23)24-19-11-4-12-20-24;/h1-20H;1H/q+1;/p-1
• InChIKey: WAGFXJQAIZNSEQ-UHFFFAOYSA-M
• PubChem CID: 164911

Type(s) of Resistant Mechanism of This Drug

  IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-01: Infectious/parasitic diseases

Bacterial infection [ICD-11: 1A00-1C4Z]

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Irregularity in Drug Uptake and Drug Efflux (IDUE)

Key Molecule: Multidrug resistance protein PmpM (PMPM) [1]

• Resistant Disease: Pseudomonas aeruginosa infection [ICD-11: 1A00-1C4Z]
• Molecule Alteration: Expression; Inherence
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Escherichia coli kAM32/pSTV28; 562
• Experiment for Molecule Alteration: PCR amplification and DNA sequence assay
• Experiment for Drug Resistance: MIC assay
• Mechanism Description: PmpM is a multi drug efflux pump coupled with hydrogen ions, which reduces the intracellular drug concentration and produces drug resistance.

ICD-12: Respiratory system diseases

Pneumonia [ICD-11: CA40]

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Irregularity in Drug Uptake and Drug Efflux (IDUE)

Key Molecule: MATE family efflux transporter (ABEM) [2]

• Resistant Disease: Acinetobacter baumannii infection [ICD-11: CA40.4]
• Molecule Alteration: Expression; Inherence
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Escherichia coli kAM32; 562
• Experiment for Drug Resistance: MIC assay
• Mechanism Description: AbeM was found to be an H+-coupled multidrug efflux pump and a unique member of the MATE family which lead to drug resistance.

References

• Ref 1: An H(+)-coupled multidrug efflux pump, PmpM, a member of the MATE family of transporters, from Pseudomonas aeruginosa. J Bacteriol. 2004 Jan;186(1):262-5. doi: 10.1128/JB.186.1.262-265.2004.
• Ref 2: AbeM, an H+-coupled Acinetobacter baumannii multidrug efflux pump belonging to the MATE family of transporters. Antimicrob Agents Chemother. 2005 Oct;49(10):4362-4. doi: 10.1128/AAC.49.10.4362-4364.2005.