Drug Information

Drug (ID: DG00006) and It's Reported Resistant Information

Name	Apigenin
Synonyms	Apigenin; 520-36-5; 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one; Chamomile; Versulin; Spigenin; Apigenol; 4',5,7-Trihydroxyflavone; Apigenine; C.I. Natural Yellow 1; 5,7,4'-Trihydroxyflavone; Pelargidenon 1449; 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone; 2-(p-Hydroxyphenyl)-5,7-dihydroxychromone; UCCF 031; NSC 83244; UNII-7V515PI7F6; 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; 5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one; CCRIS 3789; CHEBI:18388; CHEMBL28; EINECS 208-292-3; 4H-1-Benzopyran-4-one, 5,7-di Click to Show/Hide
Indication	In total 1 Indication(s) Discovery agent [ICD-11: N.A.] Investigative [1]
Structure
Target	Aldose reductase (AKR1B1)	ALDR_HUMAN	[1]
	Androgen receptor messenger RNA (AR mRNA)	ANDR_HUMAN	[1]
	Aromatase (CYP19A1)	CP19A_HUMAN	[1]
	Casein kinase II alpha (CSNK2A1)	CSK21_HUMAN	[1]
	Cyclin-dependent kinase 6 (CDK6)	CDK6_HUMAN	[1]
	Cytochrome P450 1B1 (CYP1B1)	CP1B1_HUMAN	[1]
	Estradiol 17 beta-dehydrogenase 1 (17-beta-HSD1)	DHB1_HUMAN	[1]
	Influenza Neuraminidase (Influ NA)	NRAM_I33A0	[1]
	Plasmodium CDK Pfmrk (Malaria Pfmrk)	P90584_PLAFA	[1]
Click to Show/Hide the Molecular Information and External Link(s) of This Drug
Formula	C15H10O5
IsoSMILES	C1=CC(=CC=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O
InChI	1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
InChIKey	KZNIFHPLKGYRTM-UHFFFAOYSA-N
PubChem CID	5280443
ChEBI ID	CHEBI:18388
TTD Drug ID	D00RIX
VARIDT ID	DR00822
DrugBank ID	DB07352

Type(s) of Resistant Mechanism of This Drug

EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-02: Benign/in-situ/malignant neoplasm

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Brain cancer [ICD-11: 2A00]

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Key Molecule: hsa-miR-423-5p				[1]
Molecule Alteration	Expression		Down-regulation	Molecule Info
Sensitive Disease	Glioma [ICD-11: 2A00.1]			Disease Info
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	Bax/BCL2/caspase-3 signaling pathway		Activation	hsa04933
	Mitochondrial signaling pathway		Regulation	hsa04217
In Vitro Model	CD133-positive cells	Brain	Homo sapiens (Human)	CVCL_IR55
Experiment for Molecule Alteration	qRT-PCR
Experiment for Drug Resistance	MTT assay; Annexin V/PI apoptosis assay; Caspase-3 activity assay
Mechanism Description	Retracted-miR423-5p knockdown enhances the sensitivity of glioma stem cells to apigenin through the mitochondrial pathway.

References

Ref 1	miR-423-5p knockdown enhances the sensitivity of glioma stem cells to apigenin through the mitochondrial pathway. Tumour Biol. 2017 Apr;39(4):1010428317695526. doi: 10.1177/1010428317695526.