Disease Information

General Information of the Disease (ID: DIS00571)

• Name: Bacteremia
• ICD: ICD-11: MA15

Type(s) of Resistant Mechanism of This Disease

  ADTT: Aberration of the Drug's Therapeutic Target

Drug Resistance Data Categorized by Drug

Approved Drug(s) 2 drug(s) in total

Fluconazole

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Aberration of the Drug's Therapeutic Target (ADTT)

Key Molecule: Lanosterol 14-alpha demethylase (ERG11) [1]

• Resistant Disease: candidemia [ICD-11: MA15.1]
• Resistant Drug: Fluconazole
• Molecule Alteration: Mutation; G307A
• Experimental Note: Revealed Based on the Cell Line Data
• Experiment for Molecule Alteration: Genotyping assay
• Mechanism Description: The FLCR rate was 26.7% (91/341), out of which 75.8% (69/91) harboured the?ERG11Y132F?mutation. Patients infected with FLCR isolates had a higher mortality rate compared to their susceptible counterparts (49% for FLCR vs. 42% for susceptible). ECR rate was 2.1% (7/341) and isolates carried?FKS1F652L/R658G/W1370R?mutations. Concerningly, four ECR isolates were MDR. FLCR isolates grouped in distinct clusters without evidence of inter-hospital transmission, whereas large clusters containing susceptible isolates from all centres were noted.

Key Molecule: Lanosterol 14-alpha demethylase (ERG11) [1]

• Resistant Disease: candidemia [ICD-11: MA15.1]
• Resistant Drug: Fluconazole
• Molecule Alteration: Mutation; K444R/E+N450D
• Experimental Note: Revealed Based on the Cell Line Data
• Experiment for Molecule Alteration: Genotyping assay
• Mechanism Description: The FLCR rate was 26.7% (91/341), out of which 75.8% (69/91) harboured the?ERG11Y132F?mutation. Patients infected with FLCR isolates had a higher mortality rate compared to their susceptible counterparts (49% for FLCR vs. 42% for susceptible). ECR rate was 2.1% (7/341) and isolates carried?FKS1F652L/R658G/W1370R?mutations. Concerningly, four ECR isolates were MDR. FLCR isolates grouped in distinct clusters without evidence of inter-hospital transmission, whereas large clusters containing susceptible isolates from all centres were noted.

Key Molecule: Lanosterol 14-alpha demethylase (ERG11) [1]

• Resistant Disease: candidemia [ICD-11: MA15.1]
• Resistant Drug: Fluconazole
• Molecule Alteration: Mutation; W1370R
• Experimental Note: Revealed Based on the Cell Line Data
• Experiment for Molecule Alteration: Genotyping assay
• Mechanism Description: The FLCR rate was 26.7% (91/341), out of which 75.8% (69/91) harboured the?ERG11Y132F?mutation. Patients infected with FLCR isolates had a higher mortality rate compared to their susceptible counterparts (49% for FLCR vs. 42% for susceptible). ECR rate was 2.1% (7/341) and isolates carried?FKS1F652L/R658G/W1370R?mutations. Concerningly, four ECR isolates were MDR. FLCR isolates grouped in distinct clusters without evidence of inter-hospital transmission, whereas large clusters containing susceptible isolates from all centres were noted.

Micafungin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Aberration of the Drug's Therapeutic Target (ADTT)

Key Molecule: D-glucan-1,3-beta--UDP glucosyltransferase (FKS1) [1]

• Resistant Disease: candidemia [ICD-11: MA15.1]
• Resistant Drug: Micafungin
• Molecule Alteration: Mutation; F652L
• Experimental Note: Revealed Based on the Cell Line Data
• Experiment for Molecule Alteration: Genotyping assay
• Mechanism Description: The FLCR rate was 26.7% (91/341), out of which 75.8% (69/91) harboured the?ERG11Y132F?mutation. Patients infected with FLCR isolates had a higher mortality rate compared to their susceptible counterparts (49% for FLCR vs. 42% for susceptible). ECR rate was 2.1% (7/341) and isolates carried?FKS1F652L/R658G/W1370R?mutations. Concerningly, four ECR isolates were MDR. FLCR isolates grouped in distinct clusters without evidence of inter-hospital transmission, whereas large clusters containing susceptible isolates from all centres were noted.

Key Molecule: D-glucan-1,3-beta--UDP glucosyltransferase (FKS1) [1]

• Resistant Disease: candidemia [ICD-11: MA15.1]
• Resistant Drug: Micafungin
• Molecule Alteration: Mutation; Q24K+L28M+R30E+A92K
• Experimental Note: Revealed Based on the Cell Line Data
• Experiment for Molecule Alteration: Genotyping assay
• Mechanism Description: The FLCR rate was 26.7% (91/341), out of which 75.8% (69/91) harboured the?ERG11Y132F?mutation. Patients infected with FLCR isolates had a higher mortality rate compared to their susceptible counterparts (49% for FLCR vs. 42% for susceptible). ECR rate was 2.1% (7/341) and isolates carried?FKS1F652L/R658G/W1370R?mutations. Concerningly, four ECR isolates were MDR. FLCR isolates grouped in distinct clusters without evidence of inter-hospital transmission, whereas large clusters containing susceptible isolates from all centres were noted.

Key Molecule: D-glucan-1,3-beta--UDP glucosyltransferase (FKS1) [1]

• Resistant Disease: candidemia [ICD-11: MA15.1]
• Resistant Drug: Micafungin
• Molecule Alteration: Mutation; Y132F
• Experimental Note: Revealed Based on the Cell Line Data
• Experiment for Molecule Alteration: Genotyping assay
• Mechanism Description: The FLCR rate was 26.7% (91/341), out of which 75.8% (69/91) harboured the?ERG11Y132F?mutation. Patients infected with FLCR isolates had a higher mortality rate compared to their susceptible counterparts (49% for FLCR vs. 42% for susceptible). ECR rate was 2.1% (7/341) and isolates carried?FKS1F652L/R658G/W1370R?mutations. Concerningly, four ECR isolates were MDR. FLCR isolates grouped in distinct clusters without evidence of inter-hospital transmission, whereas large clusters containing susceptible isolates from all centres were noted.

References

• Ref 1: Multicentre Study of Candida parapsilosis Blood Isolates in Turkiye Highlights an Increasing Rate of Fluconazole Resistance and Emergence of Echinocandin and Multidrug Resistance. Mycoses. 2024 Nov;67(11):e70000.