Disease Information

General Information of the Disease (ID: DIS00564)

• Name: Lung cancer
• ICD: ICD-11: 2C25

Type(s) of Resistant Mechanism of This Disease

  UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Gefitinib

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Unusual Activation of Pro-survival Pathway (UAPP)

Key Molecule: Programmed cell death 1 ligand 1 (PD-L1) [1]

• Resistant Disease: egfr-mutant luad [ICD-11: 2C25.0]
• Resistant Drug: Gefitinib
• Molecule Alteration: Expression; Down-regulation
• Experimental Note: Revealed Based on the Cell Line Data
• Cell Pathway Regulation: Cell autophagy; Inhibition; hsa04140
• In Vitro Model: PC-9 cells; Lung; Homo sapiens (Human); CVCL_B260
• Experiment for Molecule Alteration: Western blot assay
• Experiment for Drug Resistance: CCK8 assay
• Mechanism Description: Our results suggested that PD-L1 might play a role in promoting autophagy and inhibiting apoptosis, which was responsible for the generation of primary resistance to EGFR-TKIs, and the combination therapy exerted a synergistic antitumor effect by inhibiting the activation of the MAPK/ERK signaling pathway.

Key Molecule: Programmed cell death 1 ligand 1 (PD-L1) [1]

• Resistant Disease: egfr-mutant luad [ICD-11: 2C25.0]
• Resistant Drug: Gefitinib
• Molecule Alteration: Expression; Up-regulation
• Experimental Note: Revealed Based on the Cell Line Data
• Cell Pathway Regulation: Cell autophagy; Inhibition; hsa04140
• In Vitro Model: HCC827 cells; Lung; Homo sapiens (Human); CVCL_2063
• Experiment for Molecule Alteration: Western blot assay
• Experiment for Drug Resistance: CCK8 assay
• Mechanism Description: Our results suggested that PD-L1 might play a role in promoting autophagy and inhibiting apoptosis, which was responsible for the generation of primary resistance to EGFR-TKIs, and the combination therapy exerted a synergistic antitumor effect by inhibiting the activation of the MAPK/ERK signaling pathway.

References

• Ref 1: PD-L1 induces autophagy and primary resistance to EGFR-TKIs in EGFR-mutant lung adenocarcinoma via the MAPK signaling pathway. Cell Death Dis. 2024 Aug 1;15(8):555.