Disease Information

General Information of the Disease (ID: DIS00342)

Type(s) of Resistant Mechanism of This Disease

IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Drug

Approved Drug(s)

2 drug(s) in total

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Prednisolone

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Irregularity in Drug Uptake and Drug Efflux (IDUE)		Click to Show/Hide
Key Molecule: Multidrug resistance protein 1 (ABCB1)			[1]
Resistant Disease	Nephrotic syndrome [ICD-11: GB41.0]
Resistant Drug	Prednisolone		Drug Info
Molecule Alteration	SNP	c.G2677T/A	Molecule Info
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Blood sample		N.A.
Experiment for Molecule Alteration	PCR-RFLP
Mechanism Description	MDR1 G2677T/A polymorphism was significantly associated with steroid resistance.
Key Molecule: Multidrug resistance protein 1 (ABCB1)			[1]
Resistant Disease	Nephrotic syndrome [ICD-11: GB41.0]
Resistant Drug	Prednisolone		Drug Info
Molecule Alteration	SNP	c.G2677T/A	Molecule Info
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Blood sample		N.A.
Experiment for Molecule Alteration	PCR-RFLP
Mechanism Description	MDR1 G2677T/A polymorphism was significantly associated with steroid resistance.

Steroid

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Irregularity in Drug Uptake and Drug Efflux (IDUE)		Click to Show/Hide
Key Molecule: Multidrug resistance protein 1 (ABCB1)			[2]
Resistant Disease	Idiopathic nephrotic syndrome [ICD-11: GB41.1]
Resistant Drug	Steroid		Drug Info
Molecule Alteration	Expression	Up-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
Mechanism Description	The up-regualtion of mdr1 led to steroid resistance in the idiopathic nephrotic syndrome.
Key Molecule: Multidrug resistance protein 1 (ABCB1)			[2]
Resistant Disease	Idiopathic nephrotic syndrome [ICD-11: GB41.1]
Resistant Drug	Steroid		Drug Info
Molecule Alteration	Expression	Up-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
Mechanism Description	The up-regualtion of mdr1 led to steroid resistance in the idiopathic nephrotic syndrome.

References

Ref 1	Multi-drug resistance-1 gene polymorphisms in nephrotic syndrome: impact on susceptibility and response to steroids .Gene. 2013 Nov 10;530(2):201-7. doi: 10.1016/j.gene.2013.08.045. Epub 2013 Aug 27. 10.1016/j.gene.2013.08.045
Ref 2	Association of ACE and MDR1 Gene Polymorphisms with Steroid Resistance in Children with Idiopathic Nephrotic Syndrome .Genet Test Mol Biomarkers. 2015 Aug;19(8):454-6. doi: 10.1089/gtmb.2015.0077. Epub 2015 Jul 8. 10.1089/gtmb.2015.0077