Drug Information

Drug (ID: DG00552) and It's Reported Resistant Information

• Name: Steroid
• Indication:
  In total 1 Indication(s)
  Rheumatoid arthritis [ICD-11: FA20]; Approved; [1]
• Drug Resistance Disease(s):
  Disease(s) with Clinically Reported Resistance for This Drug (1 diseases)
  Nephrotic syndrome [ICD-11: GB41]; [1]
• Target: .; NOUNIPROTAC; [1]

Type(s) of Resistant Mechanism of This Drug

  IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-16: Genitourinary system diseases

Nephrotic syndrome [ICD-11: GB41]

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Irregularity in Drug Uptake and Drug Efflux (IDUE)

Key Molecule: Multidrug resistance protein 1 (ABCB1) [1]

• Molecule Alteration: Expression; Up-regulation
• Resistant Disease: Idiopathic nephrotic syndrome [ICD-11: GB41.1]
• Experimental Note: Identified from the Human Clinical Data
• Mechanism Description: The up-regualtion of mdr1 led to steroid resistance in the idiopathic nephrotic syndrome.

Key Molecule: Multidrug resistance protein 1 (ABCB1) [1]

• Molecule Alteration: Expression; Up-regulation
• Resistant Disease: Idiopathic nephrotic syndrome [ICD-11: GB41.1]
• Experimental Note: Identified from the Human Clinical Data
• Mechanism Description: The up-regualtion of mdr1 led to steroid resistance in the idiopathic nephrotic syndrome.

References

• Ref 1: Association of ACE and MDR1 Gene Polymorphisms with Steroid Resistance in Children with Idiopathic Nephrotic Syndrome .Genet Test Mol Biomarkers. 2015 Aug;19(8):454-6. doi: 10.1089/gtmb.2015.0077. Epub 2015 Jul 8. 10.1089/gtmb.2015.0077