Disease Information

General Information of the Disease (ID: DIS00211)

• Name: Uterine cancer
• ICD: ICD-11: 2C78

Type(s) of Resistant Mechanism of This Disease

  UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Doxorubicin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Unusual Activation of Pro-survival Pathway (UAPP)

Key Molecule: Reticulocalbin 1 (RCN1) [1]

• Resistant Disease: Uterine cancer [ICD-11: 2C78.0]
• Molecule Alteration: Expression; Up-regulation
• Resistant Drug: Doxorubicin
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: MES-SA cells; Uterus; Homo sapiens (Human); CVCL_1404
• Experiment for Molecule Alteration: Western blotting assay
• Experiment for Drug Resistance: MTT assay
• Mechanism Description: RCN1 silencing has a significant role on doxorubicin-induced apoptosis in resistant cells, MES-SA/DxR-2 uM and MES-SA/DxR-8 uM, implying RCN1 knockdown has an auxiliary effect to increase resistant cell death during doxorubicin treatment.

References

• Ref 1: Identification of up- and down-regulated proteins in doxorubicin-resistant uterine cancer cells: reticulocalbin-1 plays a key role in the development of doxorubicin-associated resistance .Pharmacol Res. 2014 Dec;90:1-17. doi: 10.1016/j.phrs.2014.08.007. Epub 2014 Sep 19. 10.1016/j.phrs.2014.08.007