Disease Information

General Information of the Disease (ID: DIS00127)

Name	Serious necrotizing pneumonia
ICD	ICD-11: CA43
Resistance Map

Type(s) of Resistant Mechanism of This Disease

IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Drug

Approved Drug(s)

6 drug(s) in total

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Chloramphenicol

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Irregularity in Drug Uptake and Drug Efflux (IDUE)		Click to Show/Hide
Key Molecule: Lincomycin resistance efflux pump (LMRS)			[1]
Resistant Disease	Staphylococcus aureus infection [ICD-11: 1B54.0]
Resistant Drug	Chloramphenicol		Drug Info
Molecule Alteration	Expression	Up-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Escherichia coli kAM32		562
	Staphylococcus aureus OM505		1280
Experiment for Molecule Alteration	Whole genome sequence assay; Allelic frequency measurement assay
Experiment for Drug Resistance	Broth microdilution method assay
Mechanism Description	LmrS is a multidrug efflux pump of the major facilitator superfamily from staphylococcus aureus.

Florfenicol

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Irregularity in Drug Uptake and Drug Efflux (IDUE)		Click to Show/Hide
Key Molecule: Lincomycin resistance efflux pump (LMRS)			[1]
Resistant Disease	Staphylococcus aureus infection [ICD-11: 1B54.0]
Resistant Drug	Florfenicol		Drug Info
Molecule Alteration	Expression	Up-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Escherichia coli kAM32		562
	Staphylococcus aureus OM505		1280
Experiment for Molecule Alteration	Whole genome sequence assay; Allelic frequency measurement assay
Experiment for Drug Resistance	Broth microdilution method assay
Mechanism Description	LmrS is a multidrug efflux pump of the major facilitator superfamily from staphylococcus aureus.

Kanamycin

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Irregularity in Drug Uptake and Drug Efflux (IDUE)		Click to Show/Hide
Key Molecule: Lincomycin resistance efflux pump (LMRS)			[1]
Resistant Disease	Staphylococcus aureus infection [ICD-11: 1B54.0]
Resistant Drug	Kanamycin		Drug Info
Molecule Alteration	Expression	Up-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Escherichia coli kAM32		562
	Staphylococcus aureus OM505		1280
Experiment for Molecule Alteration	Whole genome sequence assay; Allelic frequency measurement assay
Experiment for Drug Resistance	Broth microdilution method assay
Mechanism Description	LmrS is a multidrug efflux pump of the major facilitator superfamily from staphylococcus aureus.

Linezolid

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Irregularity in Drug Uptake and Drug Efflux (IDUE)		Click to Show/Hide
Key Molecule: Lincomycin resistance efflux pump (LMRS)			[1]
Resistant Disease	Staphylococcus aureus infection [ICD-11: 1B54.0]
Resistant Drug	Linezolid		Drug Info
Molecule Alteration	Expression	Up-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Escherichia coli kAM32		562
	Staphylococcus aureus OM505		1280
Experiment for Molecule Alteration	Whole genome sequence assay; Allelic frequency measurement assay
Experiment for Drug Resistance	Broth microdilution method assay
Mechanism Description	LmrS is a multidrug efflux pump of the major facilitator superfamily from staphylococcus aureus.

Streptomycin

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Irregularity in Drug Uptake and Drug Efflux (IDUE)		Click to Show/Hide
Key Molecule: Lincomycin resistance efflux pump (LMRS)			[1]
Resistant Disease	Staphylococcus aureus infection [ICD-11: 1B54.0]
Resistant Drug	Streptomycin		Drug Info
Molecule Alteration	Expression	Up-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Escherichia coli kAM32		562
	Staphylococcus aureus OM505		1280
Experiment for Molecule Alteration	Whole genome sequence assay; Allelic frequency measurement assay
Experiment for Drug Resistance	Broth microdilution method assay
Mechanism Description	LmrS is a multidrug efflux pump of the major facilitator superfamily from staphylococcus aureus.

Trimethoprim

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Irregularity in Drug Uptake and Drug Efflux (IDUE)		Click to Show/Hide
Key Molecule: Lincomycin resistance efflux pump (LMRS)			[1]
Resistant Disease	Staphylococcus aureus infection [ICD-11: 1B54.0]
Resistant Drug	Trimethoprim		Drug Info
Molecule Alteration	Expression	Up-regulation	Molecule Info
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Escherichia coli kAM32		562
	Staphylococcus aureus OM505		1280
Experiment for Molecule Alteration	Whole genome sequence assay; Allelic frequency measurement assay
Experiment for Drug Resistance	Broth microdilution method assay
Mechanism Description	LmrS is a multidrug efflux pump of the major facilitator superfamily from staphylococcus aureus.

References

Ref 1	LmrS is a multidrug efflux pump of the major facilitator superfamily from Staphylococcus aureus. Antimicrob Agents Chemother. 2010 Dec;54(12):5406-12. doi: 10.1128/AAC.00580-10. Epub 2010 Sep 20.