Disease Information

General Information of the Disease (ID: DIS00264)
Name
Status epilepticus
ICD
ICD-11: 8A66
Resistance Map
Type(s) of Resistant Mechanism of This Disease
  IDUE: Irregularity in Drug Uptake and Drug Efflux
Drug Resistance Data Categorized by Drug
Approved Drug(s)
2 drug(s) in total
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Phenobarbital
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Irregularity in Drug Uptake and Drug Efflux (IDUE) Click to Show/Hide
Key Molecule: Multidrug resistance protein 1 (ABCB1) [1]
Resistant Disease Status epilepticus [ICD-11: 8A66.0]
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Resistant Drug Phenobarbital
 Drug Info 
Experimental Note Identified from the Human Clinical Data
Mechanism Description Pgp is involved in the resistance to phenytoin and phenobarbital but not diazepam.
Phenytoin
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Irregularity in Drug Uptake and Drug Efflux (IDUE) Click to Show/Hide
Key Molecule: Multidrug resistance protein 1 (ABCB1) [1]
Resistant Disease Status epilepticus [ICD-11: 8A66.0]
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Resistant Drug Phenytoin
 Drug Info 
Experimental Note Identified from the Human Clinical Data
Mechanism Description Pgp is involved in the resistance to phenytoin and phenobarbital but not diazepam.
References
Ref 1 Mechanisms of drug resistance in status epilepticus .Epilepsia. 2007;48 Suppl 8:74-7. doi: 10.1111/j.1528-1167.2007.01357.x. 10.1111/j.1528-1167.2007.01357.x

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