General Information of the Disease (ID: DIS00127)
Name
Serious necrotizing pneumonia
ICD
ICD-11: CA43
Resistance Map
Type(s) of Resistant Mechanism of This Disease
  IDUE: Irregularity in Drug Uptake and Drug Efflux
Drug Resistance Data Categorized by Drug
Approved Drug(s)
6 drug(s) in total
Click to Show/Hide the Full List of Drugs
Chloramphenicol
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Irregularity in Drug Uptake and Drug Efflux (IDUE) Click to Show/Hide
Key Molecule: Lincomycin resistance efflux pump (LMRS) [1]
Resistant Disease Staphylococcus aureus infection [ICD-11: 1B54.0]
Molecule Alteration Expression
Up-regulation
Resistant Drug Chloramphenicol
Experimental Note Identified from the Human Clinical Data
In Vitro Model Escherichia coli kAM32 562
Staphylococcus aureus OM505 1280
Experiment for
Molecule Alteration
Whole genome sequence assay; Allelic frequency measurement assay
Experiment for
Drug Resistance
Broth microdilution method assay
Mechanism Description LmrS is a multidrug efflux pump of the major facilitator superfamily from staphylococcus aureus.
Florfenicol
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Irregularity in Drug Uptake and Drug Efflux (IDUE) Click to Show/Hide
Key Molecule: Lincomycin resistance efflux pump (LMRS) [1]
Resistant Disease Staphylococcus aureus infection [ICD-11: 1B54.0]
Molecule Alteration Expression
Up-regulation
Resistant Drug Florfenicol
Experimental Note Identified from the Human Clinical Data
In Vitro Model Escherichia coli kAM32 562
Staphylococcus aureus OM505 1280
Experiment for
Molecule Alteration
Whole genome sequence assay; Allelic frequency measurement assay
Experiment for
Drug Resistance
Broth microdilution method assay
Mechanism Description LmrS is a multidrug efflux pump of the major facilitator superfamily from staphylococcus aureus.
Kanamycin
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Irregularity in Drug Uptake and Drug Efflux (IDUE) Click to Show/Hide
Key Molecule: Lincomycin resistance efflux pump (LMRS) [1]
Resistant Disease Staphylococcus aureus infection [ICD-11: 1B54.0]
Molecule Alteration Expression
Up-regulation
Resistant Drug Kanamycin
Experimental Note Identified from the Human Clinical Data
In Vitro Model Escherichia coli kAM32 562
Staphylococcus aureus OM505 1280
Experiment for
Molecule Alteration
Whole genome sequence assay; Allelic frequency measurement assay
Experiment for
Drug Resistance
Broth microdilution method assay
Mechanism Description LmrS is a multidrug efflux pump of the major facilitator superfamily from staphylococcus aureus.
Linezolid
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Irregularity in Drug Uptake and Drug Efflux (IDUE) Click to Show/Hide
Key Molecule: Lincomycin resistance efflux pump (LMRS) [1]
Resistant Disease Staphylococcus aureus infection [ICD-11: 1B54.0]
Molecule Alteration Expression
Up-regulation
Resistant Drug Linezolid
Experimental Note Identified from the Human Clinical Data
In Vitro Model Escherichia coli kAM32 562
Staphylococcus aureus OM505 1280
Experiment for
Molecule Alteration
Whole genome sequence assay; Allelic frequency measurement assay
Experiment for
Drug Resistance
Broth microdilution method assay
Mechanism Description LmrS is a multidrug efflux pump of the major facilitator superfamily from staphylococcus aureus.
Streptomycin
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Irregularity in Drug Uptake and Drug Efflux (IDUE) Click to Show/Hide
Key Molecule: Lincomycin resistance efflux pump (LMRS) [1]
Resistant Disease Staphylococcus aureus infection [ICD-11: 1B54.0]
Molecule Alteration Expression
Up-regulation
Resistant Drug Streptomycin
Experimental Note Identified from the Human Clinical Data
In Vitro Model Escherichia coli kAM32 562
Staphylococcus aureus OM505 1280
Experiment for
Molecule Alteration
Whole genome sequence assay; Allelic frequency measurement assay
Experiment for
Drug Resistance
Broth microdilution method assay
Mechanism Description LmrS is a multidrug efflux pump of the major facilitator superfamily from staphylococcus aureus.
Trimethoprim
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Irregularity in Drug Uptake and Drug Efflux (IDUE) Click to Show/Hide
Key Molecule: Lincomycin resistance efflux pump (LMRS) [1]
Resistant Disease Staphylococcus aureus infection [ICD-11: 1B54.0]
Molecule Alteration Expression
Up-regulation
Resistant Drug Trimethoprim
Experimental Note Identified from the Human Clinical Data
In Vitro Model Escherichia coli kAM32 562
Staphylococcus aureus OM505 1280
Experiment for
Molecule Alteration
Whole genome sequence assay; Allelic frequency measurement assay
Experiment for
Drug Resistance
Broth microdilution method assay
Mechanism Description LmrS is a multidrug efflux pump of the major facilitator superfamily from staphylococcus aureus.
References
Ref 1 LmrS is a multidrug efflux pump of the major facilitator superfamily from Staphylococcus aureus. Antimicrob Agents Chemother. 2010 Dec;54(12):5406-12. doi: 10.1128/AAC.00580-10. Epub 2010 Sep 20.

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