Disease Information

General Information of the Disease (ID: DIS00127)

Name	Serious necrotizing pneumonia
ICD	ICD-11: CA43
Resistance Map

Type(s) of Resistant Mechanism of This Disease

IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Drug

Approved Drug(s)

6 drug(s) in total

Click to Show/Hide the Full List of Drugs

Chloramphenicol

Click to Show/Hide

Drug Resistance Data Categorized by Their Corresponding Mechanisms
Irregularity in Drug Uptake and Drug Efflux (IDUE)		Click to Show/Hide
Key Molecule: Lincomycin resistance efflux pump (LMRS)			[1]
Resistant Disease	Staphylococcus aureus infection [ICD-11: 1B54.0]
Molecule Alteration	Expression	Up-regulation	Molecule Info
Resistant Drug	Chloramphenicol		Drug Info
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Escherichia coli kAM32		562
	Staphylococcus aureus OM505		1280
Experiment for Molecule Alteration	Whole genome sequence assay; Allelic frequency measurement assay
Experiment for Drug Resistance	Broth microdilution method assay
Mechanism Description	LmrS is a multidrug efflux pump of the major facilitator superfamily from staphylococcus aureus.

Florfenicol

Click to Show/Hide

Drug Resistance Data Categorized by Their Corresponding Mechanisms
Irregularity in Drug Uptake and Drug Efflux (IDUE)		Click to Show/Hide
Key Molecule: Lincomycin resistance efflux pump (LMRS)			[1]
Resistant Disease	Staphylococcus aureus infection [ICD-11: 1B54.0]
Molecule Alteration	Expression	Up-regulation	Molecule Info
Resistant Drug	Florfenicol		Drug Info
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Escherichia coli kAM32		562
	Staphylococcus aureus OM505		1280
Experiment for Molecule Alteration	Whole genome sequence assay; Allelic frequency measurement assay
Experiment for Drug Resistance	Broth microdilution method assay
Mechanism Description	LmrS is a multidrug efflux pump of the major facilitator superfamily from staphylococcus aureus.

Kanamycin

Click to Show/Hide

Drug Resistance Data Categorized by Their Corresponding Mechanisms
Irregularity in Drug Uptake and Drug Efflux (IDUE)		Click to Show/Hide
Key Molecule: Lincomycin resistance efflux pump (LMRS)			[1]
Resistant Disease	Staphylococcus aureus infection [ICD-11: 1B54.0]
Molecule Alteration	Expression	Up-regulation	Molecule Info
Resistant Drug	Kanamycin		Drug Info
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Escherichia coli kAM32		562
	Staphylococcus aureus OM505		1280
Experiment for Molecule Alteration	Whole genome sequence assay; Allelic frequency measurement assay
Experiment for Drug Resistance	Broth microdilution method assay
Mechanism Description	LmrS is a multidrug efflux pump of the major facilitator superfamily from staphylococcus aureus.

Linezolid

Click to Show/Hide

Drug Resistance Data Categorized by Their Corresponding Mechanisms
Irregularity in Drug Uptake and Drug Efflux (IDUE)		Click to Show/Hide
Key Molecule: Lincomycin resistance efflux pump (LMRS)			[1]
Resistant Disease	Staphylococcus aureus infection [ICD-11: 1B54.0]
Molecule Alteration	Expression	Up-regulation	Molecule Info
Resistant Drug	Linezolid		Drug Info
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Escherichia coli kAM32		562
	Staphylococcus aureus OM505		1280
Experiment for Molecule Alteration	Whole genome sequence assay; Allelic frequency measurement assay
Experiment for Drug Resistance	Broth microdilution method assay
Mechanism Description	LmrS is a multidrug efflux pump of the major facilitator superfamily from staphylococcus aureus.

Streptomycin

Click to Show/Hide

Drug Resistance Data Categorized by Their Corresponding Mechanisms
Irregularity in Drug Uptake and Drug Efflux (IDUE)		Click to Show/Hide
Key Molecule: Lincomycin resistance efflux pump (LMRS)			[1]
Resistant Disease	Staphylococcus aureus infection [ICD-11: 1B54.0]
Molecule Alteration	Expression	Up-regulation	Molecule Info
Resistant Drug	Streptomycin		Drug Info
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Escherichia coli kAM32		562
	Staphylococcus aureus OM505		1280
Experiment for Molecule Alteration	Whole genome sequence assay; Allelic frequency measurement assay
Experiment for Drug Resistance	Broth microdilution method assay
Mechanism Description	LmrS is a multidrug efflux pump of the major facilitator superfamily from staphylococcus aureus.

Trimethoprim

Click to Show/Hide

Drug Resistance Data Categorized by Their Corresponding Mechanisms
Irregularity in Drug Uptake and Drug Efflux (IDUE)		Click to Show/Hide
Key Molecule: Lincomycin resistance efflux pump (LMRS)			[1]
Resistant Disease	Staphylococcus aureus infection [ICD-11: 1B54.0]
Molecule Alteration	Expression	Up-regulation	Molecule Info
Resistant Drug	Trimethoprim		Drug Info
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Escherichia coli kAM32		562
	Staphylococcus aureus OM505		1280
Experiment for Molecule Alteration	Whole genome sequence assay; Allelic frequency measurement assay
Experiment for Drug Resistance	Broth microdilution method assay
Mechanism Description	LmrS is a multidrug efflux pump of the major facilitator superfamily from staphylococcus aureus.

References

Ref 1	LmrS is a multidrug efflux pump of the major facilitator superfamily from Staphylococcus aureus. Antimicrob Agents Chemother. 2010 Dec;54(12):5406-12. doi: 10.1128/AAC.00580-10. Epub 2010 Sep 20.