Disease Information

General Information of the Disease (ID: DIS00106)

• Name: Cervix epitheloid carcinoma
• ICD: ICD-11: 2E66

Type(s) of Resistant Mechanism of This Disease

  EADR: Epigenetic Alteration of DNA, RNA or Protein

  UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Etoposide

Drug Sensitivity Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Key Molecule: hsa-mir-29b [1]

• Sensitive Disease: Negroid cervix epitheloid carcinoma [ICD-11: 2E66.Y]
• Molecule Alteration: Expression; Up-regulation
• Sensitive Drug: Etoposide
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: Hela cells; Cervix uteri; Homo sapiens (Human); CVCL_0030
• Experiment for Molecule Alteration: RT-PCR
• Experiment for Drug Resistance: xCELLigence cell viability assay; Flow cytometry assay; Caspase-3 activity assay
• Mechanism Description: microRNA hsa-miR29b potentiates etoposide toxicity in HeLa cells via down-regulation of Mcl-1.

Unusual Activation of Pro-survival Pathway (UAPP)

Key Molecule: Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) [1]

• Sensitive Disease: Negroid cervix epitheloid carcinoma [ICD-11: 2E66.Y]
• Molecule Alteration: Expression; Down-regulation
• Sensitive Drug: Etoposide
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: Hela cells; Cervix uteri; Homo sapiens (Human); CVCL_0030
• Experiment for Molecule Alteration: Western blot analysis
• Experiment for Drug Resistance: xCELLigence cell viability assay; Flow cytometry assay; Caspase-3 activity assay
• Mechanism Description: microRNA hsa-miR29b potentiates etoposide toxicity in HeLa cells via down-regulation of Mcl-1.

References

• Ref 1: MicroRNA hsa-miR-29b potentiates etoposide toxicity in HeLa cells via down-regulation of Mcl-1. Toxicol In Vitro. 2017 Apr;40:289-296. doi: 10.1016/j.tiv.2017.02.005. Epub 2017 Feb 6.