Molecule Information

General Information of the Molecule (ID: Mol04448)

• Name: Circ_0072732 ,Homo sapiens
• Synonyms: Circ_0072732
• Molecule Type: Circular RNA

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Sunitinib

Drug Sensitivity Data Categorized by Their Corresponding Mechanisms

Unusual Activation of Pro-survival Pathway (UAPP)

Disease Class: Kidney cancer [ICD-11: 2C90.1] [1]

• Sensitive Disease: Kidney cancer [ICD-11: 2C90.1]
• Sensitive Drug: Sunitinib
• Molecule Alteration: Expression; Down-regulation
• Experimental Note: Revealed Based on the Cell Line Data
• Cell Pathway Regulation: Hsa_circ_0072732 /miR-548b-3p/ SLC7A11 signaling pathway; Regulation; N.A.
• In Vitro Model: 769-P cells; Kidney; Homo sapiens (Human); CVCL_1050
• In Vitro Model: 786-O cells; Kidney; Homo sapiens (Human); CVCL_1051
• In Vitro Model: Caki-1 cells; Kidney; Homo sapiens (Human); CVCL_0234
• In Vitro Model: OSRC-2 cells; Kideny; Homo sapiens (Human); N.A.
• In Vitro Model: A-498 cells; Kidney; Homo sapiens (Human); CVCL_1056
• In Vitro Model: ACHN cells; Pleural effusion; Homo sapiens (Human); CVCL_1067
• In Vitro Model: OSRC-2 cells; Kideny; Homo sapiens (Human); N.A.
• Experiment for Molecule Alteration: qRT-PCR; Western blot assay
• Experiment for Drug Resistance: CCK8 assay
• Mechanism Description: Hsa_circ_0072732 was highly expressed in RCC cells. The silence of Hsa_circ_0072732 could increase RCC sensitivity to sunitinib. Hsa_circ_0072732 contributed to sunitinib chemoresistance by impairing ferroptosis. Hsa_circ_0072732 exerts its function mainly by acting as sponges for miR-548b-3p and regulating the expression SLC7A11.

References

• Ref 1: Hsa_circ_0072732 enhances sunitinib resistance of renal cell carcinoma by inhibiting ferroptosis. Discov Oncol. 2024 Nov 23;15(1):700.