Molecule Information

General Information of the Molecule (ID: Mol04326)

• Name: Small ribosomal subunit protein uS2 (RPSA) ,Homo sapiens
• Synonyms: 37 kDa laminin receptor precursor ; 37/67 kDa laminin receptor ; 40S ribosomal protein SA; 67 kDa laminin receptor ; Colon carcinoma laminin-binding protein; Laminin receptor 1 ; Laminin-binding protein precursor p40 ; Multidrug resistance-associated protein MGr1-Ag; NEM/1CHD4
• Molecule Type: Protein
• Gene Name: RPSA
• Gene ID: 3921
• Sequence:
  MSGALDVLQMKEEDVLKFLAAGTHLGGTNLDFQMEQYIYKRKSDGIYIINLKRTWEKLLL
  AARAIVAIENPADVSVISSRNTGQRAVLKFAAATGATPIAGRFTPGTFTNQIQAAFREP
  R LLVVTDPRADHQPLTEASYVNLPTIALCNTDSPLRYVDIAIPCNNKGAHSVGLMWWML
  AR EVLRMRGTISREHPWEVMPDLYFYRDPEEIEKEEQAAAEKAVTKEEFQGEWTAPAPE
  FTA TQPEVADWSEGVQVPSVPIQQFPTEDWSAQPATEDWSAAPTAQATEWVGATTDWS
• Function: Required for the assembly and/or stability of the 40Sribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40Sribosomal subunits. Also functions as a cell surface receptor forlaminin. Plays a role in cell adhesion to the basement membrane and inthe consequent activation of signaling transduction pathways. May playa role in cell fate determination and tissue morphogenesis. Acts as aPPP1R16B-dependent substrate of PPP1CA. {ECO:0000255|HAMAP-Rule:MF_03016, ECO:0000269|PubMed:16263087,ECO:0000269|PubMed:6300843}.; Acts as a receptor for the Adeno-associated viruses 2,3,8 and 9. {ECO:0000269|PubMed:16973587}.; Acts as a receptor for the Denguevirus. {ECO:0000269|PubMed:15507651}.; Acts as a receptor for the Sindbisvirus. {ECO:0000269|PubMed:1385835}.; Acts as a receptor for the Venezuelanequine encephalitis virus. {ECO:0000269|PubMed:1385835}.; Acts as a receptor for the pathogenicprion protein. {ECO:0000269|PubMed:11689427,ECO:0000269|PubMed:9396609}.; Acts as a receptor for bacteria.{ECO:0000269|PubMed:15516338}.
• Uniprot ID: RSSA_HUMAN
• Ensembl ID: ENSG0000016802815
• HGNC ID: HGNC:6502

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Pyrazinamide

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Tuberculosis [ICD-11: 1B10.0] [1]

• Resistant Disease: Tuberculosis [ICD-11: 1B10.0]
• Resistant Drug: Pyrazinamide
• Molecule Alteration: Mutation; rpoB gene
• Experimental Note: Revealed Based on the Cell Line Data
• Experiment for Molecule Alteration: GeneSeq assay; Bioinformatics assay
• Mechanism Description: Out of total 112 mycobacterial positive cultures, five?M. bovis?were isolated and underwent WGS. All sequenced strains belonged to?Mycobacterium tuberculosis var bovis, spoligotype BOV_1; BOV_11. Resistance gene mutations were determined in 100% of strains to pyrazinamide (pncA?and?rpsA), isoniazid (KatG?and?ahpC), ethambutol (embB,?embC,?embR?and?ubiA), streptomycin (rpsl) and fluoroquinolones (gyrA?and?gyrB). Rifampin (rpoB?and?rpoC) and delamanid (fbiC) resistance genes were found in 80% of strains. The major represented virulence classes were the secretion system, cell surface components and regulation system.

References

• Ref 1: Genetic diversities and drug resistance in Mycobacterium bovis isolates from zoonotic tuberculosis using whole genome sequencing. BMC Genomics. 2024 Nov 1;25(1):1024.