Molecule Information

General Information of the Molecule (ID: Mol04292)

Name	Glycerol-3-phosphate phosphatase (PGP) ,Homo sapiens
Synonyms	Aspartate-based ubiquitous Mg(2+)-dependent phosphatase ; Phosphoglycolate phosphatase Click to Show/Hide
Molecule Type	Protein
Gene Name	PGP
Gene ID	283871
Sequence	MAAAEAGGDDARCVRLSAERAQALLADVDTLLFDCDGVLWRGETAVPGAPEALRALRARG KRLGFITNNSSKTRAAYAEKLRRLGFGGPAGPGASLEVFGTAYCTALYLRQRLAGAPAP K AYVLGSPALAAELEAVGVASVGVGPEPLQGEGPGDWLHAPLEPDVRAVVVGFDPHFSY MK LTKALRYLQQPGCLLVGTNMDNRLPLENGRFIAGTGCLVRAVEMAAQRQADIIGKPS RFI FDCVSQEYGINPERTVMVGDRLDTDILLGATCGLKTILTLTGVSTLGDVKNNQESD CVSK KKMVPDFYVDSIADLLPALQG Click to Show/Hide
Function	Glycerol-3-phosphate phosphatase hydrolyzing glycerol-3-phosphate into glycerol. Thereby, regulates the cellular levels ofglycerol-3-phosphate a metabolic intermediate of glucose, lipid andenergy metabolism. Was also shown to have a 2-phosphoglycolatephosphatase activity and a tyrosine-protein phosphatase activity.However, their physiological relevance is unclear . Invitro, also has a phosphatase activity toward ADP, ATP, GDP and GTP . {ECO:0000250\|UniProtKB:Q8CHP8,ECO:0000269\|PubMed:26755581}. Click to Show/Hide
Uniprot ID	PGP_HUMAN
Ensembl ID	ENSG000001842079
HGNC ID	HGNC:8909
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Doxorubicin

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Unusual Activation of Pro-survival Pathway (UAPP)			Click to Show/Hide
Disease Class: B-cell non-Hodgkin lymphoma [ICD-11: 2A85.2]				[1]
Resistant Disease	B-cell non-Hodgkin lymphoma [ICD-11: 2A85.2]			Disease Info
Resistant Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Up-regulation
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	PI3K/AKT/mTOR signaling pathway		Inhibition	hsa04151
In Vitro Model	RAJI/DOX cells	Blood	Homo sapiens (Human)	N.A.
Mechanism Description	The expression of Pgp and the phosphorylation levels of AKT and mTOR in RAJI/DOX cell line were both higher than those in RAJI cell line. NVP-BEZ235 downregulated the phosphorylation levels of AKT and mTOR in RAJI/DOX cell line. NVP-BEZ235 inhibited the proliferation of RAJI/DOX cell line, and the effect was obvious when it was cooperated with doxorubicin. The constitutive activation of PI3K/AKT/mTOR pathway of RAJI/DOX cell line was more serious than RAJI cell line. NVP-BEZ235 reversed doxorubicin resistance of RAJI/DOX cell line by inhibiting the PI3K/AKT/mTOR signal pathway.

References

Ref 1	[Reversal Effect of NVP-BEZ235 on Doxorubicin-Resistance in Burkitt Lymphoma RAJI Cell Line]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2024 Apr;32(2):476-482.