Molecule Information

General Information of the Molecule (ID: Mol04280)

• Name: Non-structural protein 12 (NSP12) ,Severe acute respiratory syndrome coronavirus 2
• Synonyms: Non-structural protein 12 (NSP12)
• Molecule Type: Protein

Kingdom: Orthornavirae
Phylum: Pisuviricota
Class: Pisoniviricetes
Order: Nidovirales
Family: Coronaviridae
Genus: Betacoronavirus
Species: Severe acute respiratory syndrome coronavirus

Type(s) of Resistant Mechanism of This Molecule

  ADTT: Aberration of the Drug's Therapeutic Target

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Remdesivir

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Aberration of the Drug's Therapeutic Target (ADTT)

Disease Class: Corona Virus Disease 2019 [ICD-11: 1D92.0] [1]

• Resistant Disease: Corona Virus Disease 2019 [ICD-11: 1D92.0]
• Resistant Drug: Remdesivir
• Molecule Alteration: Single mutations; E802A+E802D+V791I+C799F
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: Huh-7.5 cells; N.A.; Homo sapiens (Human); CVCL_7927
• Experiment for Molecule Alteration: Biochemical assay
• Experiment for Drug Resistance: In-vitro infection assay
• Mechanism Description: Remdesivir target nsp12, thereby reducing the viral load. However, the emergence of resistant mutations in 3CLpro and nsp12 could impact the efficiency of these small molecule drug therapeutics.

References

• Ref 1: SARS-CoV-2 Resistance to Small Molecule Inhibitors. Curr Clin Microbiol Rep. 2024 Sep;11(3):127-139.