Molecule Information

General Information of the Molecule (ID: Mol04249)

• Name: 16S rRNA adenine dimethyltransferase (KsgA) ,Escherichia coli
• Synonyms: 16S rRNA adenine dimethyltransferase (KsgA)
• Molecule Type: Protein

Kingdom: N.A.
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Escherichia
Species: Escherichia coli

Type(s) of Resistant Mechanism of This Molecule

  DISM: Drug Inactivation by Structure Modification

Drug Resistance Data Categorized by Drug

Approved Drug(s) 3 drug(s) in total

Cefsulodin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Drug Inactivation by Structure Modification (DISM)

Disease Class: Lactobacillus casei infection [ICD-11: 1A00-1C4Z] [1]

• Resistant Disease: Lactobacillus casei infection [ICD-11: 1A00-1C4Z]
• Resistant Drug: Cefsulodin
• Molecule Alteration: Missense mutation; A1518/1519
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: Pseudomonas aeruginosa; 1763
• Experiment for Molecule Alteration: PCR; Southern blot assay
• Experiment for Drug Resistance: MIC assay
• Mechanism Description: SOD enzymatic activity and SodM protein levels are reduced in the ksgA mutant strain;The absence of ksgA contributes to an altered antibiotic response

Hygromycin B

Drug Sensitivity Data Categorized by Their Corresponding Mechanisms

Drug Inactivation by Structure Modification (DISM)

Disease Class: Lactobacillus casei infection [ICD-11: 1A00-1C4Z] [1]

• Sensitive Disease: Lactobacillus casei infection [ICD-11: 1A00-1C4Z]
• Sensitive Drug: Hygromycin B
• Molecule Alteration: Missense mutation; A1182V
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: Pseudomonas aeruginosa; 1763
• Experiment for Molecule Alteration: PCR; Southern blot assay
• Experiment for Drug Resistance: MIC assay
• Mechanism Description: SOD enzymatic activity and SodM protein levels are reduced in the ksgA mutant strain;The absence of ksgA contributes to an altered antibiotic response

Macrolides

Drug Sensitivity Data Categorized by Their Corresponding Mechanisms

Drug Inactivation by Structure Modification (DISM)

Disease Class: Lactobacillus casei infection [ICD-11: 1A00-1C4Z] [1]

• Sensitive Disease: Lactobacillus casei infection [ICD-11: 1A00-1C4Z]
• Sensitive Drug: Macrolides
• Molecule Alteration: Missense mutation; A1182V
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: Pseudomonas aeruginosa; 1763
• Experiment for Molecule Alteration: PCR; Southern blot assay
• Experiment for Drug Resistance: MIC assay
• Mechanism Description: SOD enzymatic activity and SodM protein levels are reduced in the ksgA mutant strain;The absence of ksgA contributes to an altered antibiotic response

References

• Ref 1: 16S rRNA methyltransferase KsgA contributes to oxidative stress and antibiotic resistance in Pseudomonas aeruginosa. Sci Rep. 2024 Nov 3;14(1):26484.