Molecule Information

General Information of the Molecule (ID: Mol04238)
Name
L-type amino acid transporter 1 (LAT1/SLC7A5) ,Homo sapiens
Synonyms
L-type amino acid transporter 1 (LAT1/SLC7A5)
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Molecule Type
Protein
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Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Type(s) of Resistant Mechanism of This Molecule
  IDUE: Irregularity in Drug Uptake and Drug Efflux
Drug Resistance Data Categorized by Drug
Approved Drug(s)
1 drug(s) in total
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Topotecan
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
  Irregularity in Drug Uptake and Drug Efflux (IDUE) Click to Show/Hide
Disease Class: Retinoblastoma [ICD-11: 2D02.2] [1]
Resistant Disease Retinoblastoma [ICD-11: 2D02.2]
 Disease Info 
Resistant Drug Topotecan
 Drug Info 
Molecule Alteration Expression
Down-regulation
Experimental Note Discovered Using In-vivo Testing Model
Experiment for
Molecule Alteration		 qRT-PCR
Experiment for
Drug Resistance		 MTT assay
Mechanism Description Similar Genomic Alterations but Distinctive Expression of Influx/Efflux Transporters Between Chemoresistant and Parental Cells
References
Ref 1 Mimicking Retinoblastoma Treatment With Repeated Topotecan or Melphalan Develops Cross-Resistance to Classic Agents But Not to Repurposed Drugs. Invest Ophthalmol Vis Sci. 2024 Dec 2;65(14):14.

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