Molecule Information

General Information of the Molecule (ID: Mol04237)

• Name: KBL-1 protein (KBL-1) ,Caenorhabditis elegans
• Synonyms: KBL-1 protein (KBL-1)
• Molecule Type: Protein

Kingdom: Metazoa
Phylum: Nematoda
Class: Chromadorea
Order: Rhabditida
Family: Rhabditidae
Genus: Caenorhabditis
Species: Caenorhabditis elegans

Type(s) of Resistant Mechanism of This Molecule

  DISM: Drug Inactivation by Structure Modification

Drug Resistance Data Categorized by Drug

Approved Drug(s) 5 drug(s) in total

Amoxicillin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Drug Inactivation by Structure Modification (DISM)

Disease Class: Lactobacillus casei infection [ICD-11: 1A00-1C4Z] [1]

• Resistant Disease: Lactobacillus casei infection [ICD-11: 1A00-1C4Z]
• Resistant Drug: Amoxicillin
• Molecule Alteration: Expression; .
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: S. maltophilia JUNP497; N.A.
• Mechanism Description: Recombinant KBL-1 protein had hydrolytic activities against all the beta-lactams tested, except for aztreonam (Table?3). Recombinant KBL-1 efficiently hydrolyzed the penicillins, including ampicillin, amoxicillin, penicillin G, and piperacillin with?kcat/km?values of 0.422 to 1.166.

Ampicillin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Drug Inactivation by Structure Modification (DISM)

Disease Class: Lactobacillus casei infection [ICD-11: 1A00-1C4Z] [1]

• Resistant Disease: Lactobacillus casei infection [ICD-11: 1A00-1C4Z]
• Resistant Drug: Ampicillin
• Molecule Alteration: Expression; .
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: S. maltophilia JUNP497; N.A.
• Mechanism Description: Recombinant KBL-1 protein had hydrolytic activities against all the beta-lactams tested, except for aztreonam (Table?3). Recombinant KBL-1 efficiently hydrolyzed the penicillins, including ampicillin, amoxicillin, penicillin G, and piperacillin with?kcat/km?values of 0.422 to 1.166.

Benzylpenicillin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Drug Inactivation by Structure Modification (DISM)

Disease Class: Lactobacillus casei infection [ICD-11: 1A00-1C4Z] [1]

• Resistant Disease: Lactobacillus casei infection [ICD-11: 1A00-1C4Z]
• Resistant Drug: Benzylpenicillin
• Molecule Alteration: Expression; .
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: S. maltophilia JUNP497; N.A.
• Mechanism Description: Recombinant KBL-1 protein had hydrolytic activities against all the beta-lactams tested, except for aztreonam (Table?3). Recombinant KBL-1 efficiently hydrolyzed the penicillins, including ampicillin, amoxicillin, penicillin G, and piperacillin with?kcat/km?values of 0.422 to 1.166.

Piperacillin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Drug Inactivation by Structure Modification (DISM)

Disease Class: Lactobacillus casei infection [ICD-11: 1A00-1C4Z] [1]

• Resistant Disease: Lactobacillus casei infection [ICD-11: 1A00-1C4Z]
• Resistant Drug: Piperacillin
• Molecule Alteration: Expression; .
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: S. maltophilia JUNP497; N.A.
• Mechanism Description: Recombinant KBL-1 protein had hydrolytic activities against all the beta-lactams tested, except for aztreonam (Table?3). Recombinant KBL-1 efficiently hydrolyzed the penicillins, including ampicillin, amoxicillin, penicillin G, and piperacillin with?kcat/km?values of 0.422 to 1.166.

Propicillin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Drug Inactivation by Structure Modification (DISM)

Disease Class: Lactobacillus casei infection [ICD-11: 1A00-1C4Z] [1]

• Resistant Disease: Lactobacillus casei infection [ICD-11: 1A00-1C4Z]
• Resistant Drug: Propicillin
• Molecule Alteration: Expression; .
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: S. maltophilia JUNP497; N.A.
• Mechanism Description: Recombinant KBL-1 protein had hydrolytic activities against all the beta-lactams tested, except for aztreonam (Table?3). Recombinant KBL-1 efficiently hydrolyzed the penicillins, including ampicillin, amoxicillin, penicillin G, and piperacillin with?kcat/km?values of 0.422 to 1.166.

References

• Ref 1: Stenotrophomonas maltophilia from Nepal Producing Two Novel Antibiotic Inactivating Enzymes, a Class A beta-Lactamase KBL-1 and an Aminoglycoside 6'-N-Acetyltransferase AAC(6')-Iap. Microbiol Spectr. 2022 Aug 31;10(4):e0114322.