Drug Information

Drug (ID: DG00983) and It's Reported Resistant Information

• Name: Propicillin
• Synonyms: Propicillin; propicilline; 551-27-9; Propicilina; Propicillinum; UNII-8X1R260V33; (1-Phenoxypropyl)penicillin; CHEBI:52429; 8X1R260V33; (2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenoxybutanoylamino)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenoxybutanoyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; Propicillin potassium salt; 6beta-(2-phenoxybutanamido)-2,2-dimethylpenam-3alpha-carboxylic acid; Propicilina [INN-Spanish]; Propicilline [INN-French]; Propicillinum [INN-Latin]; Propicillin [INN:BAN:DCF]; EINECS 208-995-5; Propicillin (BAN); NCGC00160673-01; DSSTox_CID_26291; DSSTox_RID_81517; DSSTox_GSID_46291; SCHEMBL35608; .alpha.-phenoxypropylpenicillin; CHEMBL2105612; DTXSID3046291; Tox21_111976; DB13660; (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2-phenoxybutanamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; CAS-551-27-9; D08438
• Indication:
  In total 1 Indication(s)
  Bacterial infection [ICD-11: 1A00-1C4Z]; Approved; [1]
• Drug Resistance Disease(s):
  Disease(s) with Resistance Information Discovered by Cell Line Test for This Drug (1 diseases)
  Bacterial infection [ICD-11: 1A00-1C4Z]; [2]
  Disease(s) with Clinically Reported Resistance for This Drug (1 diseases)
  Staphylococcus meningitis [ICD-11: 1B54]; [1]
• Formula: C18H22N2O5S
• IsoSMILES: CCC(C(=O)N[C@H]1[C@@H]2N(C1=O)[C@H](C(S2)(C)C)C(=O)O)OC3=CC=CC=C3
• InChI: 1S/C18H22N2O5S/c1-4-11(25-10-8-6-5-7-9-10)14(21)19-12-15(22)20-13(17(23)24)18(2,3)26-16(12)20/h5-9,11-13,16H,4H2,1-3H3,(H,19,21)(H,23,24)/t11 ,12-,13+,16-/m1/s1
• InChIKey: HOCWPKXKMNXINF-XQERAMJGSA-N
• PubChem CID: 92879
• ChEBI ID: CHEBI:52429
• TTD Drug ID: D0WV4M
• VARIDT ID: DR00720

Type(s) of Resistant Mechanism of This Drug

  DISM: Drug Inactivation by Structure Modification

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-01: Infectious/parasitic diseases

Bacterial infection [ICD-11: 1A00-1C4Z]

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Drug Inactivation by Structure Modification (DISM)

Key Molecule: KBL-1 protein (KBL-1) [2]

• Resistant Disease: Lactobacillus casei infection [ICD-11: 1A00-1C4Z]
• Molecule Alteration: Expression; .
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: S. maltophilia JUNP497; N.A.
• Mechanism Description: Recombinant KBL-1 protein had hydrolytic activities against all the beta-lactams tested, except for aztreonam (Table?3). Recombinant KBL-1 efficiently hydrolyzed the penicillins, including ampicillin, amoxicillin, penicillin G, and piperacillin with?kcat/km?values of 0.422 to 1.166.

References

• Ref 1: Comparative inhibition of methicillin-resistant strains of Staphylococcus aureus by lysostaphin and other antibiotics .Appl Microbiol. 1968 Aug;16(8):1174-8. doi: 10.1128/am.16.8.1174-1178.1968. 10.1128/am.16.8.1174-1178.1968
• Ref 2: Stenotrophomonas maltophilia from Nepal Producing Two Novel Antibiotic Inactivating Enzymes, a Class A beta-Lactamase KBL-1 and an Aminoglycoside 6'-N-Acetyltransferase AAC(6')-Iap. Microbiol Spectr. 2022 Aug 31;10(4):e0114322.