Molecule Information

General Information of the Molecule (ID: Mol02206)

• Name: Long non-protein coding RNA (N336694) ,Homo sapiens
• Synonyms: N336694
• Molecule Type: LncRNA
• Gene Name: N336694

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Simvastatin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Alzheimer's disease [ICD-11: 8A20.0] [1]

• Resistant Disease: Alzheimer's disease [ICD-11: 8A20.0]
• Resistant Drug: Simvastatin
• Molecule Alteration: Up-regulation; Expression/Mutation
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: SH-SY5Y cells; Abdomen; Homo sapiens (Human); CVCL_0019
• Experiment for Molecule Alteration: ELISA assay; Western bloting analysis; qRT-PCR
• Mechanism Description: Alzheimer's disease (AD) as a neurodegenerative brain disorder is a devastating pathology leading to disastrous cognitive impairments and dementia, and several studies have shown that AD is closely related to the inflammation, so anti-inflammatory treatment may provide therapeutic benefits.

References

• Ref 1: Simvastatin ameliorate memory deficits and inflammation in clinical and mouse model of Alzheimer's disease via modulating the expression of miR-106bBiomed Pharmacother. 2017 Aug;92:46-57. doi: 10.1016/j.biopha.2017.05.060. Epub 2017 May 18.