Molecule Information

General Information of the Molecule (ID: Mol02205)

• Name: Hepatocellular carcinoma up-regulated long non-coding RNA (HULC) ,Mus musculus
• Synonyms: HULC
• Molecule Type: LncRNA
• Gene Name: HULC

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Rhodium trichloride hydrate

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Gastric adenocarcinoma [1]

• Resistant Disease: Gastric adenocarcinoma [ICD-11: 2B72.0]
• Resistant Drug: Rhodium trichloride hydrate
• Molecule Alteration: Up-regulation; Expression
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: MGC-803 cells; Gastric; Homo sapiens (Human); CVCL_5334
• In Vitro Model: SGC7901 cells; Gastric; Homo sapiens (Human); CVCL_0520
• In Vivo Model: BALB/c nude mice model; Mus musculus
• Experiment for Molecule Alteration: Western bloting analysis; qRT-PCR
• Experiment for Drug Resistance: CCK8 assay
• Mechanism Description: METase/LncRNA HULC/FoxM1 reduced cisplatin resistance in gastric cancer by suppressing autophagy.

References

• Ref 1: METase/lncRNA HULC/FoxM1 reduced cisplatin resistance in gastric cancer by suppressing autophagyJ Cancer Res Clin Oncol. 2019 Oct;145(10):2507-2517. doi: 10.1007/s00432-019-03015-w. Epub 2019 Sep 4.