Drug Information

Drug (ID: DG01841) and It's Reported Resistant Information

Name	Rhodium trichloride hydrate
Synonyms	Rhodium trichloride hydrate; Rhodium(III) chloride xhydrate; CDDP;cis-Diaminodichloroplatinum; Cl3H2ORh; trichlororhodium hydrate; trichlororhodium;hydrate; rhodium chloride hydrate; rhodiumtrichloride hydrate; Rhodium(III) chloride 3-hydrate; BCP26055; 0627AB; AKOS015924295; Rhodium chloride (RhCl3), hydrate (9CI); Rhodium(III) chloride hydrate, Rh =>39%; Rhodium(III) chloride hydrate, Rh 38-40 %; A814863; trichlororhodium hydrate;Rhodium(III) Chloride Hydrate; Rhodium(III) chloride hydrate, 99.98% trace metals basis; Rhodium(III) chloride hydrate, Rh =>39% trace metal grade 99.99%; Rhodium(III) chloride hydrate, crystalline, >=99.9% trace metals basis Click to Show/Hide
Structure
Drug Resistance Disease(s)	Disease(s) with Resistance Information Discovered by Cell Line Test for This Drug (1 diseases) Gastric cancer [ICD-11: 2B72] [1]
Target	.	NOUNIPROTAC	[1]
Click to Show/Hide the Molecular Information and External Link(s) of This Drug
IsoSMILES	O.Cl[Rh](Cl)Cl
InChI	InChI=1S/3ClH.H2O.Rh/h3*1H;1H2;/q;;;;+3/p-3
InChIKey	HSSMNYDDDSNUKH-UHFFFAOYSA-K
PubChem CID	16211510
DrugBank ID	DB00515

Type(s) of Resistant Mechanism of This Drug

EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-02: Benign/in-situ/malignant neoplasm

Click to Show/Hide the Resistance Disease of This Class

Gastric cancer [ICD-11: 2B72]

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Key Molecule: Hepatocellular carcinoma up-regulated long non-coding RNA (HULC)				[1]
Molecule Alteration	Up-regulation		Expression	Molecule Info
Resistant Disease	Gastric adenocarcinoma [ICD-11: 2B72.0]			Disease Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	MGC-803 cells	Gastric	Homo sapiens (Human)	CVCL_5334
	SGC7901 cells	Gastric	Homo sapiens (Human)	CVCL_0520
In Vivo Model	BALB/c nude mice model			Mus musculus
Experiment for Molecule Alteration	Western bloting analysis; qRT-PCR
Experiment for Drug Resistance	CCK8 assay
Mechanism Description	METase/LncRNA HULC/FoxM1 reduced cisplatin resistance in gastric cancer by suppressing autophagy.

References

Ref 1	METase/lncRNA HULC/FoxM1 reduced cisplatin resistance in gastric cancer by suppressing autophagyJ Cancer Res Clin Oncol. 2019 Oct;145(10):2507-2517. doi: 10.1007/s00432-019-03015-w. Epub 2019 Sep 4.