Molecule Information

General Information of the Molecule (ID: Mol02173)

• Name: Predicted gene 14461 (Gm14461) ,Mus musculus
• Synonyms: Gm14461
• Molecule Type: LncRNA
• Gene Name: Gm14461
• Gene ID: 329436
• Location: chr2:77,878,840-78,132,796[+]
• Ensembl ID: ENSMUSG00000054510

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Investigative Drug(s) 1 drug(s) in total

Picric acid

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Trigeminal neuralgia [1]

• Resistant Disease: Trigeminal neuralgia [ICD-11: 8B82.0]
• Resistant Drug: Picric acid
• Molecule Alteration: Up-regulation; Expression
• Experimental Note: Discovered Using In-vivo Testing Model
• In Vivo Model: C57BL/6 J mouse model; Mus musculus
• Experiment for Molecule Alteration: qRT-PCR; Western bloting analysis; Knockdown assay; Overexpression assay; Mimic
• Mechanism Description: Gm14461 promoted pain transmission (reduced MWT value) in a CCI-ION-induced mouse TN model.

References

• Ref 1: Effects of long non-coding RNA Gm14461 on pain transmission in trigeminal neuralgiaJ Inflamm (Lond). 2020 Jan 3;17:1. doi: 10.1186/s12950-019-0231-1. eCollection 2020.