Disease Information

General Information of the Disease (ID: DIS00273)

• Name: Trigeminal neuralgia
• ICD: ICD-11: 8B82

Type(s) of Resistant Mechanism of This Disease

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Investigative Drug(s) 1 drug(s) in total

Picric acid

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Key Molecule: Predicted gene 14461 (Gm14461) [1]

• Resistant Disease: Trigeminal neuralgia [ICD-11: 8B82.0]
• Molecule Alteration: Up-regulation; Expression
• Resistant Drug: Picric acid
• Experimental Note: Discovered Using In-vivo Testing Model
• In Vivo Model: C57BL/6 J mouse model; Mus musculus
• Experiment for Molecule Alteration: qRT-PCR; Western bloting analysis; Knockdown assay; Overexpression assay; Mimic
• Mechanism Description: Gm14461 promoted pain transmission (reduced MWT value) in a CCI-ION-induced mouse TN model.

References

• Ref 1: Effects of long non-coding RNA Gm14461 on pain transmission in trigeminal neuralgiaJ Inflamm (Lond). 2020 Jan 3;17:1. doi: 10.1186/s12950-019-0231-1. eCollection 2020.