Molecule Information

General Information of the Molecule (ID: Mol02164)

• Name: Nuclear paraspeckle assembly transcript 1 (NEAT1) ,Mus musculus
• Synonyms: Neat1
• Molecule Type: LncRNA
• Gene Name: Neat1
• Gene ID: 66961
• Location: chr19:5,874,736-5,895,898[-]
• Ensembl ID: ENSMUSG00000092274

Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus

Type(s) of Resistant Mechanism of This Molecule

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Investigative Drug(s) 1 drug(s) in total

Catalpol

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Disease Class: Diabetic cardiomyopathy [1]

• Resistant Disease: Diabetic cardiomyopathy [ICD-11: BC43.7]
• Resistant Drug: Catalpol
• Molecule Alteration: Down-regulation; Interaction
• Experimental Note: Discovered Using In-vivo Testing Model
• In Vitro Model: Mouse cardiomyocytes; Heart; Mus musculus (Mouse); CVCL_JK52
• In Vivo Model: Diabetes male C57BL/6 mice model; Mus musculus
• Experiment for Molecule Alteration: Luciferase assay; Overexpression assay; Knockdown assay
• Experiment for Drug Resistance: TUNEL assay
• Mechanism Description: Catalpol alleviated myocardial damage by regulating Neat1/miR-140-5p/HDAC4 axis in DCM mice.

Disease Class: Myocardial injury [1]

• Resistant Disease: Myocardial injury [ICD-11: NB31.Z]
• Resistant Drug: Catalpol
• Molecule Alteration: Up-regulation; Interaction
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: Mouse harvested primary cardiomyocytes; N.A.; Mus musculus (Mouse); N.A.
• Experiment for Molecule Alteration: Luciferase assay; ChIP assay
• Experiment for Drug Resistance: TUNEL assay; Cellular ROS detection assay
• Mechanism Description: Inhibition of LncRNA Neat1 by catalpol via suppressing transcriptional activity of NF-kappa-B attenuates cardiomyocyte apoptosis.

References

• Ref 1: Catalpol attenuates cardiomyocyte apoptosis in diabetic cardiomyopathy via Neat1/miR-140-5p/HDAC4 axisBiochimie. 2019 Oct;165:90-99. doi: 10.1016/j.biochi.2019.05.005. Epub 2019 May 9.