Disease Information

General Information of the Disease (ID: DIS00412)

• Name: Myocardial injury
• ICD: ICD-11: NB31

Type(s) of Resistant Mechanism of This Disease

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Investigative Drug(s) 1 drug(s) in total

Catalpol

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Key Molecule: Nuclear paraspeckle assembly transcript 1 (NEAT1) [1]

• Resistant Disease: Myocardial injury [ICD-11: NB31.Z]
• Molecule Alteration: Up-regulation; Interaction
• Resistant Drug: Catalpol
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: Mouse harvested primary cardiomyocytes; N.A.; Mus musculus (Mouse); N.A.
• Experiment for Molecule Alteration: Luciferase assay; ChIP assay
• Experiment for Drug Resistance: TUNEL assay; Cellular ROS detection assay
• Mechanism Description: Inhibition of LncRNA Neat1 by catalpol via suppressing transcriptional activity of NF-kappa-B attenuates cardiomyocyte apoptosis.

References

• Ref 1: Catalpol attenuates cardiomyocyte apoptosis in diabetic cardiomyopathy via Neat1/miR-140-5p/HDAC4 axisBiochimie. 2019 Oct;165:90-99. doi: 10.1016/j.biochi.2019.05.005. Epub 2019 May 9.