Molecule Information

General Information of the Molecule (ID: Mol01981)

Name	Nectin cell adhesion molecule 4 (NECTIN4) ,Homo sapiens
Synonyms	NECTIN4; LNIR; PRR4; PVRL4 Click to Show/Hide
Molecule Type	Protein
Gene Name	NECTIN4
Gene ID	81607
Location	chr1:161,070,998-161,089,558[-]
Sequence	MPLSLGAEMWGPEAWLLLLLLLASFTGRCPAGELETSDVVTVVLGQDAKLPCFYRGDSGE QVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQA DEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPALEEGQGLTLAASCTAEGSPAPS VTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHIL HVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRVDGDTL GFPPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLDPQEDSGKQVDLVSASVVVVGVIAALL FCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHTDPRSQPEESVGLRA EGHPDSLKDNSSCSVMSEEPEGRSYSTLTTVREIETQTELLSPGSGRAEEEEDQDEGIKQ AMNHFVQENGTLRAKPTGNGIYINGRGHLV Click to Show/Hide
Function	Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells.; (Microbial infection) Acts as a receptor for measles virus. Click to Show/Hide
Uniprot ID	NECT4_HUMAN
Ensembl ID	ENSG00000143217
HGNC ID	HGNC:19688
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

ADTT: Aberration of the Drug's Therapeutic Target

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Enfortumab

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Aberration of the Drug's Therapeutic Target (ADTT)		Click to Show/Hide
Disease Class: Advanced urothelial carcinoma			[1]
Sensitive Disease	Advanced urothelial carcinoma [ICD-11: 2C92.Y]		Disease Info
Sensitive Drug	Enfortumab		Drug Info
Molecule Alteration	Function	Inhibition
Experimental Note	Identified from the Human Clinical Data
Cell Pathway Regulation	Cell growth	Inhibition	hsa05200
	Cell proliferation	Inhibition	hsa05200
	Cell apoptosis	Activation	hsa04210
Experiment for Drug Resistance	Overall survival analysis; Progression-Free Survival analysis
Mechanism Description	Nectin-4 is a cell adhesion molecule highly expressed in urothelial carcinoma that may contribute to tumor cell growth and proliferation.Enfortumab vedotin, an antibody-drug conjugate directed against Nectin-4, is comprised of a fully human monoclonal antibody specific for Nectin-4 and monomethyl auristatin E, a microtubule-disrupting agent.

Disease- and Tissue-specific Abundances of This Molecule

ICD Disease Classification 02

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Ureteral cancer [ICD-11: 2C92]

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Differential expression of molecule in resistant diseases
The Studied Tissue	Urothelium
The Specified Disease	Ureteral cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 8.91E-01; Fold-change: 5.38E-03; Z-score: 2.18E-02
Molecule expression in the diseased tissue of patients Molecule expression in the normal tissue of healthy individuals
Disease-specific Molecule Abundances		Click to View the Clearer Original Diagram
Download Molecule expression barchart for all samples Download Molecule expression data of patients in the disease section of the tissue Download Molecule expression data in the tissue of healthy individual

References

Ref 1	Enfortumab Vedotin in Previously Treated Advanced Urothelial Carcinoma .N Engl J Med. 2021 Mar 25;384(12):1125-1135. doi: 10.1056/NEJMoa2035807. Epub 2021 Feb 12. 10.1056/NEJMoa2035807