Molecule Information

General Information of the Molecule (ID: Mol01324)

Name	BRAF-activated non-protein coding RNA (BANCR) ,Homo sapiens
Synonyms	BANCR Click to Show/Hide
Molecule Type	LncRNA
Gene Name	BANCR
Gene ID	100885775
Location	chr9:69296678-69311111[-]
Ensembl ID	ENSG00000278910
HGNC ID	HGNC:43877
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s)

2 drug(s) in total

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Fentanyl

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Disease Class: Colorectal cancer				[1]
Resistant Disease	Colorectal cancer [ICD-11: 2B91.1]			Disease Info
Resistant Drug	Fentanyl			Drug Info
Molecule Alteration	Expression		Up-regulation
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	Cell apoptosis		Inhibition	hsa04210
	Cell invasion		Activation	hsa05200
	Cell migration		Activation	hsa04670
	Cell proliferation		Activation	hsa05200
In Vitro Model	SW480 cells	Colon	Homo sapiens (Human)	CVCL_0546
	LOVO cells	Colon	Homo sapiens (Human)	CVCL_0399
In Vivo Model	Nude mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	Western blot analysis
Experiment for Drug Resistance	Transwell assay
Mechanism Description	Fentanyl inhibits the invasion and migration of colorectal cancer cells via inhibiting the negative regulation of Ets-1 on BANCR.

Insulin recombinant

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Disease Class: Polycystic ovary syndrome				[2]
Resistant Disease	Polycystic ovary syndrome [ICD-11: 5A80.1]			Disease Info
Resistant Drug	Insulin recombinant			Drug Info
Molecule Alteration	Up-regulation		Expression
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Human polycystic ovary syndrome cell isolates	N.A.	Homo sapiens (Human)	N.A.
Experiment for Molecule Alteration	qRT-PCR; Western bloting analysis
Experiment for Drug Resistance	CCK8 assay
Mechanism Description	LncRNA BANCR participates in polycystic ovary syndrome by promoting cell apoptosis.

References

Ref 1	Fentanyl inhibits the invasion and migration of colorectal cancer cells via inhibiting the negative regulation of Ets-1 on BANCR. Biochem Biophys Res Commun. 2015 Sep 25;465(3):594-600. doi: 10.1016/j.bbrc.2015.08.068. Epub 2015 Aug 18.
Ref 2	LncRNA BANCR participates in polycystic ovary syndrome by promoting cell apoptosisMol Med Rep. 2019 Mar;19(3):1581-1586. doi: 10.3892/mmr.2018.9793. Epub 2018 Dec 24.