Disease Information

General Information of the Disease (ID: DIS00243)

• Name: Polycystic ovary syndrome
• ICD: ICD-11: 5A80

Type(s) of Resistant Mechanism of This Disease

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Insulin recombinant

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Key Molecule: BRAF-activated non-protein coding RNA (BANCR) [1]

• Resistant Disease: Polycystic ovary syndrome [ICD-11: 5A80.1]
• Molecule Alteration: Up-regulation; Expression
• Resistant Drug: Insulin recombinant
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Human polycystic ovary syndrome cell isolates; N.A.; Homo sapiens (Human); N.A.
• Experiment for Molecule Alteration: qRT-PCR; Western bloting analysis
• Experiment for Drug Resistance: CCK8 assay
• Mechanism Description: LncRNA BANCR participates in polycystic ovary syndrome by promoting cell apoptosis.

References

• Ref 1: LncRNA BANCR participates in polycystic ovary syndrome by promoting cell apoptosisMol Med Rep. 2019 Mar;19(3):1581-1586. doi: 10.3892/mmr.2018.9793. Epub 2018 Dec 24.