Molecule Information

General Information of the Molecule (ID: Mol01317)

Name	LOXL1 antisense RNA 1 (LOXL1-AS1) ,Homo sapiens
Synonyms	LOXL1-AS1 Click to Show/Hide
Molecule Type	LncRNA
Gene Name	ODRUL
Gene ID	100287616
Location	chr15:73908071-73928248[-]
Ensembl ID	ENSG00000261801
HGNC ID	HGNC:44169
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Doxorubicin

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Disease Class: Prostate cancer				[1]
Resistant Disease	Prostate cancer [ICD-11: 2C82.0]			Disease Info
Resistant Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Down-regulation
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	Cell apoptosis		Inhibition	hsa04210
	Cell migration		Activation	hsa04670
	Cell proliferation		Activation	hsa05200
In Vitro Model	DU-145 cells	Prostate	Homo sapiens (Human)	CVCL_0105
Experiment for Molecule Alteration	qRT-PCR
Experiment for Drug Resistance	CCK8 assay; Flow cytometry assay
Mechanism Description	LncRNA LOXL1-AS1/miR-let-7a-5p/EGFR-related pathway regulates the doxorubicin resistance of prostate cancer DU-145 cells.

Disease- and Tissue-specific Abundances of This Molecule

ICD Disease Classification 02

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Prostate cancer [ICD-11: 2C82]

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Differential expression of molecule in resistant diseases
The Studied Tissue	Prostate
The Specified Disease	Prostate adenocarcinoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 4.10E-01; Fold-change: 5.42E-03
Molecule expression in the diseased tissue of patients Molecule expression in the normal tissue of healthy individuals
Disease-specific Molecule Abundances		Click to View the Clearer Original Diagram
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Tissue-specific Molecule Abundances in Healthy Individuals

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Download the Tissue-Specific Variation(s) Profile

References

Ref 1	LncRNA LOXL1-AS1/miR-let-7a-5p/EGFR-related pathway regulates the doxorubicin resistance of prostate cancer DU-145 cells. IUBMB Life. 2019 Oct;71(10):1537-1551. doi: 10.1002/iub.2075. Epub 2019 Jun 12.